National Natural Science Foundation of China.

The extraction of interstitial fluid (ISF) from skin using microneedles (MNs) has attracted growing interest in recent years due to its potential for minimally invasive diagnostics and biosensors. ISF collection by absorption into a hydrogel MN patch is a promising way that requires the materials to have outstanding swelling ability. Here, a gelatin methacryloyl (GelMA) patch is developed with an 11 × 11 array of MNs for minimally invasive sampling of ISF. The properties of the patch can be tuned by altering the concentration of the GelMA prepolymer and the crosslinking time; patches are created with swelling ratios between 293% and 423% and compressive moduli between 3.34 MPa and 7.23 MPa. The optimized GelMA MN patch demonstrates efficient extraction of ISF. Furthermore, it efficiently and quantitatively detects glucose and vancomycin in ISF in an in vivo study. This minimally invasive approach of extracting ISF with a GelMA MN patch has the potential to complement blood sampling for the monitoring of target molecules from patients.

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Non-Hermitian parity-time (PT) symmetric systems that possess real eigenvalues have been intensively investigated in quantum mechanics and rapidly extended to optics and acoustics demonstrating a lot of unconventional wave phenomena. Here, a PT symmetric metamaterial beam is designed based on shunted piezoelectric patches and asymmetric wave scattering in the form of flexural waves is demonstrated through analytical and numerical approaches. The gain and loss components in the PT symmetric beam are realized by the introduction of negative and positive resistances into the external shunting circuits, respectively. Effective medium theory and transfer matrix method are employed to determine the effective material parameters and scattering properties of the PT symmetric metamaterial beam. Unidirectional reflectionlessness has been demonstrated analytically and numerically, together with illustrations of the PT phase transition and exceptional points. The tunability of exceptional points is studied by changing the spacing between piezoelectric patches and shunting circuit parameters. The design explores complex material parameters of the beam structure, and could open unique ways to asymmetric wave control, enhanced sensing, amplification, and localization of flexural waves.

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Modern technological advances allow for the study of systems with additional synthetic dimensions. Higher-order topological insulators in topological states of matters have been pursued in lower physical dimensions by exploiting synthetic dimensions with phase transitions. While synthetic dimensions can be rendered in the photonics and cold atomic gases, little to no work has been succeeded in acoustics because acoustic wave-guides cannot be weakly coupled in a continuous fashion. Here, we formulate the theoretical principles and manufacture acoustic crystals composed of arrays of acoustic cavities strongly coupled through modulated channels to evidence one-dimensional (1D) and two-dimensional (2D) dynamic topological pumpings. In particular, the higher-order topological edge-bulk-edge and corner-bulk-corner transport are physically illustrated in finite-sized acoustic structures. We delineate the generated 2D and four-dimensional (4D) quantum Hall effects by calculating first and second Chern numbers and physically demonstrate robustness against the geometrical imperfections. Synthetic dimensions could provide a powerful way for acoustic topological wave steering and open up a platform to explore any continuous orbit in higher-order topological matter in dimensions four and higher.

Recently, sound attenuation with ventilation is highly needed in many practical applications. In this study, we report on a subwavelength acoustic silencer, named double-layer acoustic silencer (DAS), based on compactly assembled slit-type Helmholtz resonators (SHRs) for low-frequency broadband sound insulation while preserving ventilation. A simple yet insightful theoretical model is first established to characterize the sound insulation performance in terms of transmission loss (TL) and used for microstructure designs of the DAS. The fluctuating TL of the DAS, inevitably produced by the SHR resonances, is then mitigated and optimized via the introduction of viscosity and proper SHR frequency detuning. The overall TL is numerically investigated and experimentally observed to reach beyond 30 dB over the target working band of 0.48–0.95 kHz, with a maximum exceeding 50 dB. In addition, the proposed design also provides perfect ventilation when deployed in a duct environment, due to the straight and conserved airflow cross section. We believe that the proposed acoustic silencer design and its associated theoretical model pave the way for designing and optimizing highly efficient low-frequency subwavelength acoustic liners and silencers.

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