Ischemic Modified Albumin as A Biomarker in Predicting Oxidative Stress in Patients With Acne Vulgaris

Ebrahim, A.A.; Mustafa, A.I.; Abdelhalim, W.A.; Abo-Ghanema, D.M.

doi:10.21608/bjas.2020.187209

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…Gurel et al divided the patients into three groups (patients with mild, moderate, and severe acne) and observed that there were no significant differences regarding the serum IMA level [56]. These results are consistent with those obtained by Ebrahim et al [52].…”

Section: Oxidative Stress Markers Evaluated In Acne Patientssupporting

confidence: 79%

Markers of Oxidative Stress in Patients with Acne: A Literature Review

Popa

Mitran

et al. 2023

Life

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Acne vulgaris is a chronic inflammatory skin disease of the pilosebaceous unit. Its pathogenesis is multifactorial and involves the overlap between four main processes: alteration of the keratinization, increased sebum production, colonization with Cutibacterium acnes, and inflammation. The role of oxidative stress (OS) has been intensively studied in inflammatory skin conditions such as psoriasis, vitiligo, or atopic dermatitis. However, the involvement of OS in the pathogenesis of acne is less known. The evidence accumulated over the last decade suggests that in the case of acne patients, there is an imbalance between oxidants and antioxidants. In this review, we analyzed studies that evaluated markers of OS in patients with acne, published in the last ten years, with the aim of providing new insights into the pathogenesis of acne.

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Section: Oxidative Stress Markers Evaluated In Acne Patientssupporting

confidence: 79%

Markers of Oxidative Stress in Patients with Acne: A Literature Review

Popa

Mitran

et al. 2023

Life

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“…Regarding the role of IMA as a marker of acne severity, the results are not clear. It seems that IMA levels can be influenced by the body’s compensatory mechanisms [ 36 ]. In the case of hidradenitis suppurativa, the two available studies show contradictory results.…”

Section: Discussionmentioning

confidence: 99%

Ischemia-Modified Albumin—A Potential New Marker of Oxidative Stress in Dermatological Diseases

Tampa

Mitran

et al. 2022

Medicina

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There is growing evidence that oxidative stress is involved in the pathogenesis of numerous conditions, including dermatological diseases. Various markers are available to assess oxidative stress, but none of these can be considered the ideal marker. Recent studies have shown that ischemia-modified albumin (IMA) is not only an indicator of ischemia, but also a marker of oxidative stress. We have conducted a narrative review to evaluate the role of IMA in dermatological diseases. We have identified 24 original articles that evaluated IMA in skin disorders (psoriasis, acne vulgaris, hidradenitis suppurativa, urticaria, vitiligo and Behcet’s disease) and hair disorders (alopecia areata, androgenetic alopecia and telogen effluvium). The results of the studies analyzed reveal that IMA may be considered a new marker of oxidative stress in dermatological diseases and offer new insights into the pathogenesis of these disorders and the theoretical basis for the development of new, effective, targeted therapies. To the best of our knowledge, this is the first review that gathers up data on the role of IMA in dermatological diseases.

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“…Thus, the inflammatory process contributes to the formation of acne lesions. elevated in AV patients, serum IMA levels can be considered as an independent predictor of AV susceptibility and function [37].…”

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confidence: 99%

Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin Levels as an Indicator of Oxidative Stress in Acne Vulgaris

Balık,

Fırat Oğuz

et al. 2023

Dermatol Pract Concept

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Introduction: Acne vulgaris (AV) is the most common skin disease. AV is a skin disease often associated with oxidative stress. Thiols and ischemia modified albumin (IMA) analysis are used as oxidative stress markers. Objectives: In this study, it was aimed to evaluate the blood levels of thiols and IMA, which are accepted as oxidative stress markers, and to determine the severity of the disease in AV patients whose severity is determined by the global acne score rate (GAS). Methods: Thiol parameters and IMA values were measured spectrophotometrically in blood samples taken from patients and controls. Determine VAS values in AV patients. The thiol and IMA values obtained were compared between the patient and control groups and their correlation with the patient's VAS values was evaluated. Results: In our study, in acne patients, native thiol (NT), total thiol (TT) and index 3 (I3=NT/TT*100) were significantly lower than the control group, disulfide (SS), index 1 (I1=SS/NT*100), index 2 (I2=SS/TT*100) and IMA values were found to be significantly higher. GAS values, which are accepted as an indicator of the degree and severity of acne disease, and SS, I1 and I2 showed a positive correlation, while I3 showed a negative correlation. Conclusion: Our study suggests that oxidative stress associated with AV disease pathogenesis may occur through mechanisms dependent on thiol and IMA levels. Therefore, in AV, oral supplementation or topical application of antioxidants may be a good way to increase drug efficacy or prevent potential harm.

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Ischemic Modified Albumin as A Biomarker in Predicting Oxidative Stress in Patients With Acne Vulgaris

Cited by 3 publications

References 24 publications

Markers of Oxidative Stress in Patients with Acne: A Literature Review

Markers of Oxidative Stress in Patients with Acne: A Literature Review

Ischemia-Modified Albumin—A Potential New Marker of Oxidative Stress in Dermatological Diseases

Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin Levels as an Indicator of Oxidative Stress in Acne Vulgaris

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