Markers of Oxidative Stress in Patients with Acne: A Literature Review

Popa, G; Mitran, Cristina Iulia; Mitran, Mădălina Irina; Tampa, Mircea; Matei, Clara; Popa, Mircea Ioan; Georgescu, Simona Roxana

doi:10.3390/life13071433

Cited by 10 publications

(7 citation statements)

References 89 publications

(87 reference statements)

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“…Oxidative stress in AV is manifested by changes in the activity of antioxidant enzymes, whose cofactors are minerals such as zinc, selenium, copper, manganese, and iron [52]. During oxidative stress, the level of antioxidant systems is exceeded, which causes a change in the function and molecular composition of keratinocytes and sebaceous cells and contributes to the progression of the inflammatory process [53].…”

Section: Discussionmentioning

confidence: 99%

The Antioxidant Power of a Diet May Improve the Quality of Life of Young Women with Acne Vulgaris

Zujko-Kowalska,

Jankowska,

Zujko

2024

Nutrients

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Acne vulgaris (AV) significantly reduces the quality of life (QoL) of young people, so it is important to look for factors that can improve their QoL. The aim of this study was to assess the relationship between dietary antioxidants measured using the new DAQI index and QoL measured using standardized tests. The DAQI included the following elements: antioxidant vitamins, minerals, carotenoids, polyphenols, phytosterols, lignans, and the total antioxidant capacity of the diet. The study involved 165 young women with AV, mainly students. A self-report survey was used to collect basic data on their sociodemographic status, anthropometric information, and lifestyle. The energy value of the diet and the content of vitamins, minerals, and carotenoids with antioxidant activity in the diet were estimated using 3-day food diaries and the Diet 6.0 program. The antioxidant potential of the diet and the content of polyphenols, phytosterols, lignans, and selenium were calculated based on the consumption of individual food products and available databases. The results of this study showed that the QoL of the young women with AV was impaired. However, greater adherence to an antioxidant diet reduces the risk of AV impact on the QoL by approximately 30–32% and the risk of depression by 33%. The DAQI may be used as a new indicator of diet quality in acne vulgaris.

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Section: Discussionmentioning

confidence: 99%

The Antioxidant Power of a Diet May Improve the Quality of Life of Young Women with Acne Vulgaris

Zujko-Kowalska,

Jankowska,

Zujko

2024

Nutrients

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“…Several scoring systems have been widely used in the early prediction of AP severity and in the prognostic assessment of primary sepsis, and numerous biomarkers have been applied to diagnosis and monitoring of sepsis during the course of the disease. Nonetheless, early reliable predictors of secondary sepsis in SAP are lacking (6,7).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it is crucial for physicians to identify the risk of developing sepsis and clinical outcomes in the early stage, which can guide clinical management and improve outcomes. Various complicated scoring systems are often used at the early stage to predict the disease severity and outcome of SAP, rather than the risk of secondary sepsis (5–7). Thus, it is necessary to find an early and convenient biomarker to identify patients at high risk for sepsis secondary to SAP.…”

Section: Introductionmentioning

confidence: 99%

Early Predictive Value of Presepsin for Secondary Sepsis and Mortality in Intensive Care Unit Patients With Severe Acute Pancreatitis

Wang¹,

Zhang²,

Liu³

et al. 2023

Shock

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Sepsis is the leading cause of death in patients with severe acute pancreatitis (SAP) in the intensive care unit (ICU). Early prediction of sepsis secondary to SAP developed in the late phase and of related mortality can enable appropriate treatment and improve outcomes. This study was conducted to evaluate the predictive value of presepsin in ICU patients with SAP at the early stage and compared it with established blood markers and scoring systems. Methods: This retrospective study enrolled 48 septic patients and 53 nonseptic patients admitted to ICU with SAP. Presepsin and other blood markers (procalcitonin, C-reactive protein, IL-6, white blood cell, and serum creatinine) on days 1, 3, and 7 after enrollment as well as scoring systems were assessed to predict secondary sepsis. Outcomes were evaluated at ICU discharge and on days 28 and 90. Results: Presepsin levels (on days 1, 3, and 7) were significantly higher in septic patients than in nonseptic patients. Presepsin levels showed an increasing trend over time in both sepsis and nonsepsis groups, but concentrations increased more rapidly in the sepsis group than in the nonsepsis group. Among the analyzed biomarkers, presepsin was the only blood marker independently associated with sepsis secondary to SAP on days 3 and 7, and presepsin on day 3 was independently associated with mortality at ICU discharge and on days 28 and 90. It showed similar or even better predictive accuracy for both secondary sepsis and mortality than procalcitonin and Sequential Organ Failure Assessment score. Conclusion: Presepsin could be a valuable early predictor of secondary sepsis and mortality in patients admitted to the ICU with SAP and may serve as an indicator for early risk stratification. KEYWORDS-Severe acute pancreatitis; presepsin; sepsis; infection; soluble CD14 subtype; biomarker; critically ill; inflammation METHODS Study populationThis single-center retrospective observational study was conducted in two ICUs (general and surgical ICUs

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“…These cytokines attract in ammatory cells to the site, exacerbating acne in ammation. This in ammatory cascade not only initiates acne formation but also perpetuates and worsens existing lesions [10,94].…”

Section: Oxidative Stressmentioning

confidence: 99%

Exploring Stress-Induced Mechanisms in Acne Pathogenesis

Siddiqui,

Rais,

Tahir

2024

Preprint

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Background: Acne vulgaris affects millions worldwide, with psychological stress emerging as a significant contributor to its development. Stress influences acne via hormonal fluctuations, inflammation, immune modulation, altered skin barrier function, and lifestyle changes. Understanding these mechanisms is crucial for developing effective management strategies. This study aims to elucidate the role of stress in acne pathogenesis to inform more targeted interventions.Methods: A comprehensive search encompassing databases such as PubMed, MEDLINE, Google Scholar, open access / subscription-based journals, was conducted to retrieve relevant articles for the investigation of key mechanisms through which stress impacts acne development and exacerbation. Articles were searched without any date restrictions. Utilizing the criteria delineated in the methodology section, studies were systematically reviewed to elucidate the relationship between psychological stress and acne development and exacerbation. This study adheres to relevant PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses).Results: Our investigation revealed multiple key mechanisms through which stress impacts acne development and exacerbation. Hormonal fluctuations, including increases in cortisol and androgens, stimulate sebaceous gland activity, leading to excess sebum production. Inflammation, triggered by stress-induced cytokine release, exacerbates acne lesions. Stress also impairs skin barrier function, alters immune responses, and influences lifestyle factors such as diet, sleep, and skincare habits, all of which contribute to acne severity. Additionally, neuropeptides, oxidative stress, insulin resistance, altered skin pH, vascular changes, and changes in the skin microbiome play significant roles in stress-induced acne pathogenesis. These findings highlight the varied nature of stress-acne interactions and underscore the importance of addressing both physiological and psychological factors in acne management strategies.Conclusion: Our investigation reveals stress's varied impact on acne through hormonal fluctuations, inflammation, barrier function impairment, immune modulation, behavioral factors, psychological distress, neuropeptides, oxidative stress, insulin resistance, altered skin pH, vascular changes, lifestyle habits, and skin microbiome alterations. Addressing these mechanisms underscores the need for holistic acne management strategies integrating stress reduction techniques with conventional treatments. Understanding stress-acne interplay emphasizes the importance of comprehensive approaches to improve acne outcomes, recognizing the bidirectional relationship between physiological and psychological factors in acne pathogenesis and exacerbation.

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Markers of Oxidative Stress in Patients with Acne: A Literature Review

Cited by 10 publications

References 89 publications

The Antioxidant Power of a Diet May Improve the Quality of Life of Young Women with Acne Vulgaris

The Antioxidant Power of a Diet May Improve the Quality of Life of Young Women with Acne Vulgaris

Early Predictive Value of Presepsin for Secondary Sepsis and Mortality in Intensive Care Unit Patients With Severe Acute Pancreatitis

Exploring Stress-Induced Mechanisms in Acne Pathogenesis

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