Background: Perinatal asphyxia (PA) is a major cause of morbidity and mortality in which dramatic transient impairment in liver functions occurs in some patients. Objectives: We aimed to evaluate the state of the liver in cases of Perinatal asphyxia and to assess the severity of hepatic impairment in relation to different grades of HIE. Patients and Methods: This case-control study was conducted on 100 full-term newborns with perinatal asphyxia (Group I) and 50 healthy neonates served as controls (Group II). All biochemical parameters of liver function were measured on the 1st, 3rd, and 10th day after birth. These parameters include serum alanine transferase (ALT), aspartate transferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total protein, serum albumin, serum bilirubin (total and direct), and international normalized ratio (INR), in both cases and controls. Results: Among babies with PA, 25 (25%) had an Apgar score of 0 to 3 (severe PA), 43 (43%) had an Apgar score of 4 to 5 (moderate PA) and 32 (32%) had an Apgar score of 6 to 7 (mild PA) at 5 minutes of life. HIE was found in 39% among cases of PA and the remaining 61% were normal. Among babies with PA and HIE; 25.7% had stage I, 41% had stage II and 33.3% had stage III. Impaired liver function was reported in 48% of asphyxiated babies. On the first day of life, ALT, AST, ALP, LDH, PT, and INR were significantly higher in Group I compared to Group II. However, total protein and serum albumin were significantly lower in Group I compared to Group II. ALT and AST showed a positive correlation with the severity of HIE. On the third day of life, LDH rises as the stage of HIE progressed from stage 0 to stage 3. The difference in LDH among most stages of HIE was statistically significant. Conclusion: Liver enzymes can be used as an easy early diagnostic marker to differentiate between babies with asphyxia and those without asphyxia. Also, liver enzymes can be used for the detection of the severity of PA.

Acne vulgaris is a cutaneous chronic inflammatory disorder with complex pathogenesis. The aim of this study was to evaluate the serum level of IMA in patients with AV to evaluate its role in AV pathogenesis and its possible relation with oxidative stress markers in the disease.This study was conducted as a case-control study and was conducted on 30 patients suffering from AV (Group A) and 18 apparently healthy individuals of matched age and sex as a control group (Group B). All studied subjects were tested for Serum level of Ischemia modified albumin (IMA), Serum level of Glutathione-S-Transferase (GST), Serum level of Catalase (CAT) and Serum level of Malondialdehyde (MDA). Serum IMA showed significant positive correlation with GAGS, GSH, MDA and significant negative correlation with CAT. AV grades showed significant positive correlation with GSH, MDA, IMA and significant negative correlation with CAT. No significant correlations were found in IMA with age and duration in AV group Serum IMA then MDA, GSH and CAT might play a role in AV pathogenesis. Moreover, its serum levels could be considered as independent predictor of AV susceptibility, activity and severity.

Background Three-dimensional speckle tracking echocardiography (STE) is an ideal modality for accurate assessment of myocardial deformation, the Novel 4D-Global Area strain (GAS) is a very sensitive parameter in detection of subtle changes involving the myocardium as it encompasses both global longitudinal and global circumferential strains . Objectives To investigate the predictive value of four dimensional (4D) strain echocardiography for major adverse cardio-vascular events (MACE) in ST-elevation acute myocardial infarction (STEMI) after successful reperfusion by primary PCI. Methods 171 patients who underwent successful primary PCI were enrolled and properly examined by 2D and 4D echocardiography with 4D strain parameters evaluation then followed up all-over a year for the occurrence of Major adverse Cardiovascular Events (MACE) . Results Thirty two MACE were recorded in 170 patients who completed the follow-up period for one year, compared with those without MACE, patients with MACE had PTCA done during the index Primary PCI intervention, had multi-vessel CAD affection, higher LVEDD, higher LVESD, lower 2D- LVEF, higher WMSI, higher baseline HR, higher EDV and ESV, lower 3D- LVEF, higher 3D-GLS, 3D-GCS and 3D-GAS with lower 3D-GRS, all with p-values < 0.005. Multi-variant logistic regression analysis showed that GAS was the most powerful predictor for MACE among our study population with the best cut-off value of 3D-GAS> -17, with p-value of (0.008) OR (20.668), CI (2.227-191.827) with relative risk of adverse events of 18.205 (95% CI 6.976- 47.506 – P value < 0.001). Conclusion Our data supports the superiority of 4D strain echocardiography parameters specially GAS for prediction of adverse clinical events among patients managed by successful primary PCI .

Androgenetic alopecia (AGA) which is also known as androgenic alopecia or male pattern baldness, is the most common type of progressive hair loss. Male androgenetic alopecia (MAA) is the most common form of hair loss in men, affecting 30-50% of men by age 50. Male androgenetic alopecia (MAA) occurs in a highly reproducible pattern, preferentially affecting the temples, vertex and mid frontal scalp.To estimate the Serum Amyloid A3 (SAA3) in young male patients with AGA and studying the relationship between the level of SAA3 and atherosclerosis. The investigation was done after endorsement by the Ethics advisory group on Research at Faculty of Medicine, Benha University. A composed educated assent was acquired from every member. This examination was a cross sectional case similar investigation. All patients chose from Outpatient Clinic of Dermatology, Venerology and Andrology Department of Benha University Hospitals. This examination was begun at January 2019 to June 2019.We found that the patients with grade III and IV androgenetic alopecia with family ancestry of heart illnesses and raised lipid profile levels had critical height of serum amyloid A3 than different gatherings. Male patients underneath age of 30 years with AGA exceptionally grade III, IV had raised SAA3 and have more dangers to create blood vessel atherosclerotic illness later on than the people without AGA at a similar age gathering.

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Sepsis is a common and serious neonatal problem with high morbidity and mortality particularly in resource limited communities. Broad examination endeavors have yielded numerous biomarkers which are conceivably helpful, for conclusion of sepsis as well as for forecast of its result. to examine the analytic job of RDW in 50 of full term children with sepsis and to assess its job in clinical result of neonatal sepsis. This investigation was completed on 100 youngsters conceded in neonatal emergency unit of Benha University Hospital and Benha Teaching Hospital during the period from (December 2018 to February 2020). Moral Research Committee Approval and composed assents were acquired from guardians of the youngsters 50 neonatal sepsis cases and 50 typical controls. Consideration standards: age from 1-28 days and had discoveries of sepsis either clinical or lab. Youngsters were exposed to: History taking, clinical assessment for signs of sepsis. Complete blood tally, C-receptive protein, Blood culture and affectability and assurance of RDW % were done to all children. Mean RDW % was higher among cases than controls (16.7 ±1.6 and 12.9 ±1.4respectively) (P < 0.001), then hemoglobin (HB) was lower in cases than controls P=0.542. WBCs were higher among cases contrasted with control (P <0.001). CRP was typical in all controls, and was higher in all cases. RDW % was higher in serious sepsis than mellow (19.2 ± 1.8& 16.4 ± 0.5 separately) (P < 0. 001). RDW % can fill in as a symptomatic marker and anticipate sepsis seriousness as a noteworthy distinction was found between its incentive among youngsters with mellow sepsis and extreme sepsis.

Recent studies showed that Kt/Vurea in dialysis cannot represent correctly the removal of other solutes and fluid, indicating that this parameter alone should not be used as the sole indicator of dialysis adequacy. We aimed to identify whether Erythrocyte glutathione transferase as biomarker for haemodialysis adequacy in children with End Stage Renal Disease (ESRD) on regular haemodialysis. This study was conducted on 50 persons divided into two groups. Group A: 2 5ESRD patients receiving conventional hemodialysis atBENHA university hospitals hemodialysis units. GroupB(Control): 25 aPP.arently healthy subjects. All patients was subjected to Erythrocyte glutathione transferase with ELISA technique. Our study showed that Erythrocyte glutathione transferase cut off value in HD patients 39,1 ng/dl. its sensitivity was 81% , specificity was 88,9 % and accuracy was 84%.In our study The post HD analysis of E-GST level showed significant difference between control and conventional HD (p-value 0.001&0.001) respectively. This means that E-GST has the same power to express dialysis adequacy like URR, Kt/V Urea, Also it is mirror of URR & Kt/V. Erythrocyte glutathione transferase is highly sensitive & specific marker in hemodialysis patients and its level can express hemodialysis adequacy and toxins removal in several sessions by different hemodialysis modalities.

Introduction: Neonatal Acute Kidney Injury (AKI) become a serious problem in critically ill neonates, serum creatinine level (SCr) which used to detect glomerular filtration rate has a lot of pitfalls, serum cystatin C level (SCys C) is more accurate and with better advantages. Aim of the Study: Our aim is to early detection of acute kidney injury in neonates especially low birth weight before any damage occur. Methods: This cross sectional study was conducted on 50 critically ill neonates randomly selected from the Neonatal Intensive Care Unit, Pediatric Department, in our University Hospitals. Detailed history, clinical examination, appropriate investigations were done. Plasma level of serum Cystatin C as well as SCr were done at the 1 st and 3 rd day of admission. Results: Fifty infants were recruited into this study out of which complete data were available, the study was conducted on both term and preterm infants. The mean SCr level in AK I group in the 1 st and 3 rd day respectively was 0.56 and1.13, while serum cystatin level was 31.86 and48.67 respectively with significant P Value P ≤ 0.001, SCr had a significant correlation with weight (r = 0 .992; P < 0.001), whereas serum CysC had no correlation with the infant's weight (r = 0.021; P = 0.884). There was no statistically significant difference in SCr and CysC between male and female infants. Conclusion: Serum Cystatin C is an earlier detector for AKI in critically ill neonates and un like serum creatinine has no significant correlation with birth weight.