Ischemia-modified albumin in pregnancy

Rossi, Alberto; Bortolotti, Nadia; Vescovo, Sara; Romanello, I.; Forzano, L.; Londero, Ambrogio P.; Ambrosini, Guido; Marchesoni, D.; Curcio, Francesco

doi:10.1016/j.ejogrb.2013.06.037

Cited by 30 publications

(27 citation statements)

References 32 publications

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“…[ produced during ischemic event, hence irrespective of gestational weeks it remains high throughout the pregnancy [14]. This finding supports the hypothesis that normal trophoblastic development is associated with hypoxic intrauterine environment, with increase in substrate need and change in metabolism in the fetoplacental unit [16].…”

Section: Resultssupporting

confidence: 81%

“…Poor trophoblastic invasion and spiral artery vasoreactivity results in more ischemic environment, the exaggeration of which can result in complications related to pregnancy manifested in its later half. Rossi et al, even found out that first trimester IMA levels are well above the cut-off value used for diagnosis of cardiac ischemia [14]. ROS, produced during ischemia generates highly reactive hydroxyl free radicals causing site specific modification of N-terminus of albumin resulting in loss of binding capacity of the albumin to transition metals resulting in the formation of IMA [17].…”

Section: Resultsmentioning

confidence: 99%

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Ischemia Modified Albumin as a Marker of Oxidative Stress in Normal Pregnancy

Bahinipati

Mohapatra²

2016

JCDR

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Section: Resultssupporting

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Ischemia Modified Albumin as a Marker of Oxidative Stress in Normal Pregnancy

Bahinipati

Mohapatra²

2016

JCDR

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“…Increased serum IMA has been detected in women with PE or fetal growth restriction as a consequence of defective trophoblast invasion . In the present study, significantly increased cord blood IMA was noted in neonates with SGA compared with non‐SGA neonates.…”

Section: Discussionsupporting

confidence: 59%

“…In that study, however, only 13 of 57 IUGR neonates were born to mothers with PE, whereas, in the present study, 10 of 11 SGA neonates were born to mothers with PE. Rossi et al . reported that an increase in serum IMA was found in both women with SGA fetuses and women with AGA fetuses, probably related to the physiological oxidative stress of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Ischemia‐modified albumin in preterm infants born to mothers with pre‐eclampsia

Özdemir

Enli

et al. 2018

Pediatrics International

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“…Damage caused by oxidative stress, including changes to DNA and proteins, as well as the mechanisms of DNA repair, appears to play a key role in obstetrical pathologies of placental origin, including PE and IUGR (Vascotto et al 2007;Takagi et al 2004;Kimura et al 2013;Rossi et al 2013;Tamura et al 2011). In this paper, we also focus our attention on the immunohistochemical expression of APE1/ Ref-1 (APE1).…”

Section: Introductionmentioning

confidence: 99%

Placental aging and oxidation damage in a tissue micro-array model: an immunohistochemistry study

Londero

Orsaria

Marzinotto

et al. 2016

Histochem Cell Biol

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To evaluate the expression of markers correlated with cellular senescence and DNA damage (8-hydroxy-2′-deoxy-guanosine (8-OHdG), p53, p21, APE1/Ref-1 (APE1), interleukin (IL-6 and IL-8) in placentas from healthy and pathologic pregnancies. This retrospective study considered a placental tissue micro-array containing 92 controls from different gestational ages and 158 pathological cases including preeclampsia (PE), HELLP syndrome (hemolysis, elevated liver enzymes,low platelet count), small for gestational age (SGA)fetuses, and intrauterine growth restriction (IUGR) occurringat different gestational ages. In this study, we demonstrated a significant influence of gestational age on the expression in the trophoblast of 8-OHdG, p53, p21, APE1, and IL-6. In placentas of cases affected by PE, HELLP, or IUGR, there was an increased expression of 8-OHdG, p53, APE1, and IL-6 compared to controls (only IL-8 was significantly decreased in cases). In both groups of pathology between 22- and 34-week gestation and after 34-week gestation, APE1 levels were higher in the trophoblast of women affected by hypertensive disorders of pregnancy than women carrying an IUGR fetus. The cytoplasmic expression of 8-OHdG was increased in placentas in IUGR cases compared to PE or HELLP pregnancies. In cases after 34-week gestation, p21 was higher in SGA and IUGR than in controls and late PE. Moreover, p53 was increased after 34-week gestation in IUGR pregnancies. Placentas from pathological pregnancies had an altered expression of\ud 8-OHdG, p53, p21, APE1, IL-6, and IL-8. The alterations of intracellular pathways involving these elements may be the cause or the consequence of placental dysfunction, but in any case reflect an impaired placental function, possibly due to increased aging velocity in pathologic cases

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Ischemia-modified albumin in pregnancy

Cited by 30 publications

References 32 publications

Ischemia Modified Albumin as a Marker of Oxidative Stress in Normal Pregnancy

Ischemia Modified Albumin as a Marker of Oxidative Stress in Normal Pregnancy

Ischemia‐modified albumin in preterm infants born to mothers with pre‐eclampsia

Placental aging and oxidation damage in a tissue micro-array model: an immunohistochemistry study

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