Ischemia Modified Albumin as a Marker of Oxidative Stress in Normal Pregnancy

Bahinipati, Jyotirmayee; Mohapatra, Prakash Chandra

doi:10.7860/jcdr/2016/21609.8454

Cited by 27 publications

(24 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, the severity of the disease and IMA levels were positively correlated in the same study. Studies investigating the level of IMA in healthy pregnant women and healthy non-pregnant women have shown that pregnancy is a factor that significantly increases the IMA level on its own ( 8 , 39 ) . In this study, the IMA level was significantly different in both the groups.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis

Onat¹,

Kırmızı²,

Başer³

et al. 2020

tjod

View full text Add to dashboard Cite

Objective: Preeclampsia (PE) is a dangerous complication of pregnancy and still a major cause of maternal-fetal morbidity and mortality. Its etiology remains largely unknown, but researchers have suggested oxidative stress-mediated inflammation for the same. The purpose of this study is to investigate the relationship between oxidative stress and PE as well as the usability of oxidative stress indicators such as serum ischemia-modified albumin (IMA) levels and thiol/disulfide balance in the prediction of PE. Materials and Methods: The study included 47 pregnant women with PE and 57 healthy pregnant women. We measured their serum IMA, native thiol, total thiol, and disulfide levels. Additionally, we determined the optimal cutoff values via the receiver operating characteristic curve analysis. Results: There were no differences between the two groups with respect to the maternal age, body mass index, gravida, and parity. The native and total thiol levels were found to be low when the disulfide and IMA levels were high in the patients with PE (p<0.05). When the IMA level was corrected by the albumin level (IMAR), the significant difference between the two groups disappeared. We also found that the native and total thiol concentrations were correlated with the systolic and diastolic blood pressures. The optimal cut-off values calculated for the prediction of PE were as follows: 178.45 µmol/L (with sensitivity of 72% and specificity of 83%) for native thiol, 232.55 µ mol/L (with a sensitivity of 75% and specificity of 85%) for total thiol, and 29.05 µmol/L (with sensitivity of 65% and specificity of 72%) for disulfide. Conclusion: The balance of thiol/disulfide may play a role in the pathogenesis of PE and could be used as a biological marker for PE.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The formation of reactive oxygen species (ROS) and free radicals temporarily changes the N-terminal region of albumin, which causes an increase in IMA concentration ( 7 ) . Furthermore, it has been shown to increase in the healthy pregnant women and other pregnancy-related situations ( 8 , 9 , 10 ) .…”

Section: Introductionmentioning

confidence: 99%

The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis

Onat¹,

Kırmızı²,

Başer³

et al. 2020

tjod

View full text Add to dashboard Cite

show abstract

“…Hypoxic-ischemic pregnancy may cause an increase in serum IMA. 8 For these reasons, it seems worthwhile to test the IMA molecule in cases of preeclampsia, including hypoxia and ischemia in its pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

The Role of Ischemia-modified Albumin as a Biomarker in Preeclampsia

Karaşin

Çift

2020

Rev Bras Ginecol Obstet

View full text Add to dashboard Cite

Objective Ischemia-modified albumin (IMA)is a modified type of albumin protein that is formed under oxidative stress. This study aims to compare the levels of serum IMA between normotensive and preeclamptic pregnancies and to evaluate the relationship between the severity of the disease. Methods A total of 90 pregnant women aged between 18 and 45 years participated in this cross-sectional study. The levels of serum IMA were measured by enzyme-linked immunosorbent assay in 30 preeclamptic pregnant women with the severe signs of the disease, 30 preeclamptic pregnant women, and 30 normotensive pregnant women.. The study was designed as a cross-sectional clinical study. Results When the demographic characteristics were examined, statistically significant differences were found between the groups in terms of age, gestational week at birth and blood pressure. Age was higher in the preeclampsia with signs of severity group than in the normotensive group (p = 0.033). Pregnancy week was significantly the lowest in the preeclampsia with the severity signs group (p = 0.004). In normotensive patients, IMA levels were lower than in the preeclampsia groups (p < 0.001) but there was no significant difference in terms of severity of disease (p = 0.191). According to laboratory data; only the creatinine level was significantly different between the groups. Conclusion The levels of serum IMA were higher in patients with preeclampsia than in healthy pregnancies. However, there was no significant correlation in terms of preeclampsia severity; more extensive, prospective and long-term studies are needed.

show abstract

“…IMA is accepted as a marker of oxidative stress, ischemia and endothelial disfunction. There are several recent studies that point to the relationship between IMA and infections, cardiovascular diseases and stroke . IMA levels have also been evaluated in some inflammatory and rheumatological diseases such as rheumatoid arthritis and Behçet's disease .…”

Section: Introductionmentioning

confidence: 99%

“…There are several recent studies that point to the relationship between IMA and infections, cardiovascular diseases and stroke. [14][15][16][17] IMA levels have also been evaluated in some inflammatory and rheumatological diseases such as rheumatoid arthritis and Behçet's disease. 18,19 The Birmingham Vasculitis Activity Score (BVAS) is a validated tool for assessment of disease activity in patients with many different forms of vasculitis.…”

Section: Introductionmentioning

confidence: 99%

Serum neopterin and ischemia modified albumin levels are associated with the disease activity of adult immunoglobulin A vasculitis (Henoch‐Schönlein purpura)

et al. 2019

View full text Add to dashboard Cite

Aim The aims of the study are to investigate serum neopterin and ischemia modified albumin (IMA) levels in patients with immunoglobulin A vasculitis (IgAV) and evaluate the association of these markers with disease activity and relapse. Method Thirty‐four consecutive adult patients (24 male and 10 female) admitted to the rheumatology clinic and met the IgAV American College of Rheumatology (ACR) criteria were enrolled in this cross‐sectional study. Demographic and clinical features of IgAV and a control group were recorded into a predefined protocol. Disease activity was categorized as “remission” or “active” according to Birmingham Vasculitis Activity Score (BVAS). BVAS ≥ 1 was accepted as "active". Serum neopterin levels, high‐sensitivity C‐reactive protein (hsCRP) and IMA were evaluated according to BVAS and compared to the healthy control group. Results Serum median (interquartile range) neopterin, IMA levels and hsCRP were higher in the study group than in control group (2.01 [12.5] ng/mL vs 1.77 [1.37] ng/mL, 0.67 [0.2] ng/mL vs. 0.43 [0.17] ng/mL, 5.6 [17.1] mg/L vs. 1.55 [1.6] mg/L, P = .095, P < .001 and P = .002, respectively). When evaluated according to BVAS, IMA and hsCRP levels were significantly higher in the group with active disease (0.77 [0.12] vs 0.61 [0.13] and 14.85 [4.6], P = .009 and P = .03, respectively). Serum neopterin levels were significantly higher in the active group compared to BVAS (18.95 [32.36] vs 1.63 [1.48], P < .001). Conclusion Oxidative stress is important in IgAV pathogenesis. Roles of hsCRP, neopterin and IMA as potential markers of diagnosis and disease activity seem to be worth studying in future studies with larger study groups.

show abstract

Ischemia Modified Albumin as a Marker of Oxidative Stress in Normal Pregnancy

Cited by 27 publications

References 15 publications

The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis

The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis

The Role of Ischemia-modified Albumin as a Biomarker in Preeclampsia

Serum neopterin and ischemia modified albumin levels are associated with the disease activity of adult immunoglobulin A vasculitis (Henoch‐Schönlein purpura)

Contact Info

Product

Resources

About