Is vitamin B6 deficiency an under-recognised risk in patients receiving haemodialysis? A systematic review: 2000-2010

Corken, Melissa; Porter, Judi

doi:10.1111/j.1440-1797.2011.01479.x

Cited by 21 publications

(24 citation statements)

References 46 publications

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“…Cardiovascular events are the most life-threatening complications among patients with CKD [14, 34]. In reference to CKD prognosis interpretation, it is vital to explore the relationship between H 2 S and risk factors of CVD.…”

Section: Discussionmentioning

confidence: 99%

Low Plasma Hydrogen Sulfide Is Associated with Impaired Renal Function and Cardiac Dysfunction

et al. 2018

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Background: Chronic kidney disease (CKD) has been proposed to associate with decreased hydrogen sulfide (H₂S) level. Nevertheless, the role of H₂S in the pathogenesis of CKD has not been fully investigated. Our study aimed to investigate the plasma level of endogenous H₂S in patients with different stages of CKD, and to identify the role of H₂S in the progression of CKD and its relationship with cardiovascular diseases. Methods: A total of 157 non-dialysis CKD patients were recruited in our study, with 37 age- and sex-matched healthy individuals as control. Plasma concentration of H₂S was measured with spectrophotometry. Sulfhemoglobin, the integration of H₂S and hemoglobin, was characterized and measured by dual wavelength spectrophotometry. Serum levels of homocysteine (Hcy), cardiac troponin T (cTnT), and N-terminal pro B type natriuretic peptide were measured using automated analyzers. Conventional transthoracic echocardiography was performed and left ventricular ejection fraction (LVEF) was analyzed as a sensitive parameter of cardiac dysfunction. Results: The plasma H₂S level (μmol/L) in CKD patients was significantly lower than those in healthy controls (7.32 ± 4.02 vs. 14.11 ± 5.24 μmol/L, p < 0.01). Plasma H₂S level was positively associated with estimated glomerular filtration rate (eGFR; ρ = 0.577, p < 0.01) and negatively associated with plasma indoxyl sulfate concentration (ρ = –0.554, p < 0.01). The mRNA levels of cystathionine β-synthase and cystathionine γ-lyase, 2 catalytic enzymes of H₂S formation, were significantly lower in blood mononuclear cells of CKD patients with respect to controls; however, the mRNA level of 3-mercaptopyruvate sulfurtransferase, as another H₂S-producing enzyme, was significantly higher in CKD patients. The serum concentration of Hcy, acting as the substrate of H₂S synthetase, was higher in the CKD group (p < 0.01). Specifically, the content of serum Hcy in CKD stages 3–5 patients was significantly higher than that in CKD stages 1–2, indicating an increasing trend of serum Hcy with the decline of renal function. Examination of ultrasonic cardiogram revealed a negative correlation between plasma H₂S level and LVEF (ρ = –0.204, p < 0.05) in CKD patients. The H₂S level also correlated negatively with cTnT concentration (ρ = –0.249, p < 0.01). Conclusions: Plasma H₂S level decreased with the decline of eGFR, which may contribute to the cardiac dysfunction in CKD patients.

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Section: Discussionmentioning

confidence: 99%

Low Plasma Hydrogen Sulfide Is Associated with Impaired Renal Function and Cardiac Dysfunction

et al. 2018

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“…PLP is an essential cofactor involved in many important biological processes and metabolic pathways (Corken and Porter, 2011). Inhibition by ginkgotoxin of pyridoxal kinase might lower the cellular concentration of PLP to levels that will affect the conversion of many apo-B6 enzymes into their catalytically active holo-enzyme form.…”

Section: Resultsmentioning

confidence: 99%

Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5′-phosphate, GABA and anti-epileptic drugs

Lee

Sung

Chang

et al. 2012

Disease Models &Amp; Mechanisms

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SUMMARYThe etiology of epilepsy is a very complicated, multifactorial process that is not completely understood. Therefore, the availability of epilepsy animal models induced by different mechanisms is crucial in advancing our knowledge and developing new therapeutic regimens for this disorder. Considering the advantages of zebrafish, we have developed a seizure model in zebrafish larvae using ginkgotoxin, a neurotoxin naturally occurring in Ginkgo biloba and hypothesized to inhibit the formation of the neurotransmitter γ-aminobutyric acid (GABA). We found that a 2-hour exposure to ginkgotoxin induced a seizure-like behavior in zebrafish larvae. This seizure-like swimming pattern was alleviated by the addition of either pyridoxal-5′-phosphate (PLP) or GABA and responded quickly to the anti-convulsing activity of gabapentin and phenytoin, two commonly prescribed anti-epileptic drugs (AEDs). Unexpectedly, the ginkgotoxin-induced PLP depletion in our experimental setting did not affect the homeostasis of folate-mediated one-carbon metabolism, another metabolic pathway playing a crucial role in neural function that also relies on the availability of PLP. This ginkgotoxin-induced seizure behavior was also relieved by primidone, which had been tested on a pentylenetetrazole-induced zebrafish seizure model but failed to rescue the seizure phenotype, highlighting the potential use and complementarity of this ginkgotoxin-induced seizure model for AED development. Structural and morphological characterization showed that a 2-hour ginkgotoxin exposure did not cause appreciable changes in larval morphology and tissues development. In conclusion, our data suggests that this ginkgotoxin-induced seizure in zebrafish larvae could serve as an in vivo model for epileptic seizure research and potential AED screening.

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“…In this study, good sleeping patients were found to eat adequately, especially having significantly higher intakes of vitamins B 1, B 6 and folate (Table-IV). Inadequate intake of vitamin B 1 for 21-28 days is known to cause emotional sensitivity, loss of appetite, constipation, nausea/vomiting as well as folate deficiency inducing appetite loss 29. There is abundant research about prevalence of B vitamins deficiency in HD patients whereas –to the authors’ knowledge– there is not enough study investigating the association between B vitamins deficiency and sleep.…”

Section: Discussionmentioning

confidence: 99%

What to eat for a better sleep in haemodialysis patients: Potential role of B vitamins intake and appetite

Ongan¹,

Yüksel²

2017

Pak J Med Sci

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Objective:Sleeping disorders are common among Haemodialysis-HD patients. In addition to well-known factors, food consumption impact on sleep quality needs being discovered. Aim was to examine the nutrition-related factors that may influence sleep quality in HD patients.Methods:One hundred and three patients in three HD centres participated. Data were collected with Pittsburgh Sleep Quality Index-PSQI and Questionnaire Form about socio-demographic characteristics and appetite. Biochemical findings were obtained; food consumption for three consecutive days was recorded. Independent Samples t/Mann Whitney U tests for mean comparison; Logistic Regression Analysis for determining variables affecting sleep quality, were used.Results:Mean age was 59.19±14.57 years. 51.5% were women. 37.9% had good (PSQI<5) and 62.1% had poor (PSQI≥5) sleep quality. Appetite had significant impact on sleep quality; poor sleeping risk was 4.194 fold higher in patients with bad appetite than those with good appetite (p=0.038). Biochemical findings of poor and good sleepers were similar, except for potassium and creatinine. Vitamins B1, B6 and folate intake of good and poor sleepers were significantly different. Patients with good sleep quality consumed significantly higher amounts of above B vitamins (p=0.030, p=0.036, p=0.034, respectively).Conclusions:Favourable effect of appetite and certain nutrients intake on sleep quality in HD patients was shown. Improving nutritional status of HD patients has potential to increase their sleep quality.

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Is vitamin B6 deficiency an under-recognised risk in patients receiving haemodialysis? A systematic review: 2000-2010

Cited by 21 publications

References 46 publications

Low Plasma Hydrogen Sulfide Is Associated with Impaired Renal Function and Cardiac Dysfunction

Low Plasma Hydrogen Sulfide Is Associated with Impaired Renal Function and Cardiac Dysfunction

Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5′-phosphate, GABA and anti-epileptic drugs

What to eat for a better sleep in haemodialysis patients: Potential role of B vitamins intake and appetite

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