Is there an effective therapy of interstitial cystitis/bladder pain syndrome?

Identification and characterization of rostral ventromedial medulla neurons synaptically connected to the urinary bladder afferents in female rats with or without neonatal cystitis

“…However, the expansion of nociceptive primary afferent projections to the superficial dorsal horn, which occurs following neonatal tissue damage is not observed after injuries at later postnatal ages (Ruda et al, 2000;Walker et al, 2003). On the other hand, a recent PRV tracing of bladder-related RVM neurons establishes that the supraspinal neural circuitry which underlies descending pain modulation pathway in the adult animal is already organized in the neonatal rat during postnatal day P2 even though the supraspinal pain modulatory mechanism does not become functional until the third postnatal week (i.e., day 21) and independent of noxious sensory input to the RVM early-in-life (Géranton et al, 2010;Hathway et al, 2009;Schwaller et al, 2016;Sugaya et al, 1997) Recent clinical studies documented that patients with irritable bowel syndrome (IBS) and colitis often experience sensory and motor dysfunction of the urinary bladder, and, conversely, patients diagnosed with IC experience IBS like symptoms (Alagiri et al, 1997;Dellis et al, 2019;Doiron et al, 2017). Similarly, cross-organ sensitization and overlapping pelvic pain have also been reported in experimental models of cystitis and colitis (Bielefeldt et al, 2006;Brumovsky & Gebhart, 2010;Laird et al, 2002;Malykhina, 2007;Malykhina et al, 2006;Pezzone et al, 2005;Qin et al, 2005;Sengupta, 2009;Yoshikawa et al, 2015).…”

“…Recent clinical studies documented that patients with irritable bowel syndrome (IBS) and colitis often experience sensory and motor dysfunction of the urinary bladder, and, conversely, patients diagnosed with IC experience IBS like symptoms (Alagiri et al., 1997; Dellis et al., 2019; Doiron et al., 2017). Similarly, cross‐organ sensitization and overlapping pelvic pain have also been reported in experimental models of cystitis and colitis (Bielefeldt et al., 2006; Brumovsky & Gebhart, 2010; Laird et al., 2002; Malykhina, 2007; Malykhina et al., 2006; Pezzone et al., 2005; Qin et al., 2005; Sengupta, 2009; Yoshikawa et al., 2015).…”