Is there an association between vitamin D status and risk of chronic low back pain? A nested case–control analysis in the Nord-Trøndelag Health Study

Heuch, Ingrid; Heuch, Ivar; Hagen, Knut; Mai, Xiao-Mei; Zwart, John‐Anker

doi:10.1136/bmjopen-2017-018521

Cited by 16 publications

(15 citation statements)

References 45 publications

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“…(26) there was an inverse correlation between concentration of 25 hydroxyvitamin D and VAS score in patients with LBP (r = -0.594, P < 0.001). In contrast, in a nested case-control study by Heuch et.al (8), no association was found between 25 hydroxyvitamin D status and risk of chronic LBP (OR per 10 nmol/L 25(OH)D=1.01, 95% CI 0.97 to 1.06). What matters is that the interpretation of the findings of these studies will not be bias-free, regardless of the characteristics of the population studied.…”

Section: Discussionmentioning

confidence: 78%

Lower serum 25-hydroxyvitamin D3 concentration is associated with higher pain and disability in subjects with low back pain: a case-control study

Pishgahi

Dolatkhah

Shakouri

et al. 2019

Preprint

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Objectives: Low back pain (LBP) is a common medical problem worldwide. The aim of this study is to evaluate the association between serum concentration of 25-hydroxivitamin D3 and functional disability in patients suffering from LBP in a sample of Azeri middle-aged subjects, North West of Iran.Results: In this case-control study, 63 eligible patients with LBP and 55 healthy subjects enrolled in the study. Peripheral venous blood was taken for evaluating the serum concentration of 25hydroxivitamin D3. We recognized factors related with LBP by multiple regression analyses. The average serum 25-hydroxivitamin D3 concentration in case group was significantly lower than that of the matched controlled group (26.25±15.95 vs. 34.20±14.92, p-value < 0.01 respectively). Subjects with vitamin D deficiency or insufficiency were more likely to exhibit LBP than subjects with normal serum 25-hydroxivitamin D3 concentration (OR= 2.388, 95% CI (1.114 to 5.119). According to the partial correlation analysis, there was a reverse correlation between serum 25-hydroxivitamin D3 concentration with functional disability measured by Modified Oswestry Questionnaire (r = -.307, p = .017) and also with pain intensity according to Visual analogue Scale (VAS) score (r = -.268, p = .040) whilst adjusting for age, sex and body mass index (BMI).

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Section: Discussionmentioning

confidence: 78%

Lower serum 25-hydroxyvitamin D3 concentration is associated with higher pain and disability in subjects with low back pain: a case-control study

Pishgahi

Dolatkhah

Shakouri

et al. 2019

Preprint

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“…The effect of vitamin D on the functional outcome and QoL of patients with LSS has not been elucidated but may be deduced from several studies. There is much debate about the pain relief effect of Vitamin D. Although it is a study of idiopathic chronic LBP, Cannell et al [17] have reported on the pain relief effect of vitamin D. Helde-Frankling et al [18] have commented on the pain reducing effect of Vitamin D, Cakar et al [19] said that in a cohort of 149 patients, the authors found that serum vitamin D concentration was not associated with knee pain in patients with osteoarthritis, and Heuch et al [20] said that after analyzing a data set including 1685 individuals with LBP and 3137 controls without LBP, the authors found no association between vitamin D status and risk of LBP. In addition, it appears that vitamin D may have an effect to enhance mood, but there are not sufficient studies regarding accurate mechanism [21].…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of vitamin D supplementation in functional outcome and quality of life (QoL) of lumbar spinal stenosis (LSS) requiring surgery

Chae

Choi

et al. 2020

J Orthop Surg Res

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Study design: This is a retrospective cohort comparative study. Background: Vitamin D supplementation is considered to be associated with good functional outcome. Thus, a few studies have proposed vitamin D supplementation is benefit to the functional outcome in LSS requiring surgery. The purpose of this study is to identify the prevalence of vitamin D deficiency in patients with LSS requiring surgery, and to compare the differences between the cases whether vitamin D is supplemented and vitamin D is not supplemented in terms of a QoL during postoperative 2 year. Methods: All patients with LSS who underwent surgery from March 1, 2015 to August 31, 2016 were enrolled. Among them, 61 patients with vitamin D deficiency were divided into two groups (supplemented group (A) and non-supplemented group (B)). Functional outcomes using Oswestry Disability Index (ODI) and Rolland Morris Disability Index (RMDQ) and QoL using SF-36 were evaluated at 12-month and 24-month follow-up periods. Differences in functional score and SF-36 between the vitamin D supplemented and non-supplemented group were compared. Results: Among the total 102 patients, 78 patients (76.5%) had vitamin D deficiency. Of the 78 patients, 61 patients were included, 27 patients were group A and 27 patients were group B. There was no difference in age and 25-OHD level between the two groups (all 0 > 0.05). Group A were better functional outcomes at 2 years after surgery (p < 0.05). On the QoL, group A were higher score than group B from 12 month later after surgery (p < 0.05). Conclusions: Vitamin D deficiency was highly prevalent in LSS patients (76.5%). Assessment of serum 25hydroxyvitamin D (25(OH)D) is recommended in LSS needing surgical intervention and active treatment vitamin D supplementation and maintenance of normal range should be considered for better postoperative functional outcome and QoL.

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“…First, crude OR were calculated, and then variables with P < 0•2 were introduced sequentially to the model while noting the impact of this on the association between 25(OH)D and LBP. Some studies have suggested that the association between 25(OH)D and LBP is dependent on age and sex (17,28) ; we, therefore, performed separate tests for the interaction between 25(OH)D and sex as well as age. As a sensitivity analysis, we used stepwise logistic regression to explore if the conclusion on the association between 25(OH)D and LBP would be different with stepwise variable selection.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, the authors reported that the association was confined to only studies from the Middle-Eastern/Mediterranean region attributing this to climatic and cultural factors. After this review, another nested case-control study showed no association between vitamin D status and the risk of LBP (28) and another review showed high prevalence of hypovitaminosis D in patients with LBP (29) . A recent review of randomised controlled trials that aimed to investigate the impact of vitamin D supplement on non-specific LBP or LBP resulting from osteoporosis showed that vitamin D supplementation is no more effective than placebo (27) and a major Cochrane Database systematic review has precluded a large beneficial effect of vitamin D in the treatment of painful conditions (30) .…”

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confidence: 94%

Vitamin D levels in relation to low back pain during adolescence

et al. 2020

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AbstractThis study aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D) level and low back pain (LBP) among adolescents while adjusting for potential confounders pertinent to this age group including the weight of school bags, BMI and physical activity. A cross-sectional study was conducted on 760 randomly selected adolescents in middle schools. Data on LBP and the risk factors for LBP were collected from parents by a self-administered questionnaire and from adolescents by face-to-face interview. Blood samples were tested in an accredited laboratory; and 25(OH)D was measured using liquid chromatography-tandem MS. The lifetime prevalence and the 6-month prevalence of LBP were 32·28 (95 % CI 28·97, 35·73) % and 21·26 (95 % CI 18·40, 24·33) %, respectively. There was no difference in the geometric mean of 25(OH)D between those with and without LBP in the past 6 months (28·50 nmol/l and 30·82 nmol/l, respectively; P = 0·122). There was no association between 25(OH)D and LBP in the univariable or multivariable analysis whether 25(OH)D fitted as a continuous or as a categorical variable. We found no association between vitamin D level and LBP in adolescents in an area with high prevalence of vitamin D deficiency. Although it is important to have sufficient vitamin D levels during adolescence for several other health benefits, we concluded that vitamin D is not a major determinant for LBP among adolescents in our setting.

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Is there an association between vitamin D status and risk of chronic low back pain? A nested case–control analysis in the Nord-Trøndelag Health Study

Cited by 16 publications

References 45 publications

Lower serum 25-hydroxyvitamin D3 concentration is associated with higher pain and disability in subjects with low back pain: a case-control study

Lower serum 25-hydroxyvitamin D3 concentration is associated with higher pain and disability in subjects with low back pain: a case-control study

The effectiveness of vitamin D supplementation in functional outcome and quality of life (QoL) of lumbar spinal stenosis (LSS) requiring surgery

Vitamin D levels in relation to low back pain during adolescence

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