Is there an association between Helicobacter pylori infection and hyperemesis gravidarum among Egyptian women?

Abstract

ObjectivesTo detect the association between Helicobacter pylori infection and hyperemesis gravidarum among Egyptian women. Participants and methods Thirty pregnant women with hyperemesis gravidarum were recruited from the Cairo University outpatient clinics and 30 healthy pregnant volunteers with no vomiting were selected as controls. The age range in both the groups were between 18 and 39 years and the gestational age ranged from 5 to 12 weeks. All participants were subjected to full history taking, clinical examination, and ultrasound to exclude obstetric causes of hyperemesis gravidarum. Routine and special laboratory investigations were performed to test the serum for H. pylori seropositivity IgG using an enzyme-linked immunosorbent assay. ResultsThere was a highly significant difference in the H. pylori IgG antibody titer between the cases (18.1-100 U/ml) and the controls (0.9-62.7 U/ml) (Po0.01). The number of cases found to be seropositive to H. pylori IgG (100%) was higher than the number of the control individuals (86.67%), but the difference between both the groups was not statistically significant (P = 0.37). ConclusionOur results showed that there might be an association between H. pylori infection and hyperemesis gravidarum. We recommend that further studies be carried out to confirm this finding with a larger number of participants and for a longer duration of time.

Association between Hyperemesis Gravidarum in Iraqi Women with Helicobacter pylori Infection

“…This result is in agreement with the result done by some researchers (20) who claimed that the study groups had higher anti-H. pylori IgG Ab titers and the difference was very significant between the groups (P≤0.01). In primigravida women, the H. pylori group had a higher H. pylori IgG antibody titer than the control group, and this difference was statistically significant (P ≤0.05).…”

“…The study included one hundred women during the first trimester of pregnancy from ALAlawia Teaching Hospital for Maternity in Iraq during the period from October 2021 until March 2022. Ages of total pregnancy ranged from (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) years. Total patients were divided into four groups as follows: Group one: Included 25 pregnant with severe vomiting.…”

The association between Helicobacter pylori infection and hyperemesis gravidarum

“…A small number of pregnant women have a more acute sequalae, with the most severe form known as hyperemesis gravidarum. 1 In almost 1-10% of pregnancies, symptoms may continue till 20-22 weeks. 2 Hyperemesis gravidarum (HG) is characterized by persistent nausea and vomiting accompanied by ketosis and loss of weight (>5% of the weight before pregnancy).…”

The Association Between Helicobacter Pylori Seropositivity And Risk Of Hyperemesis Gravidarum During Pregnancy

“…Hyperemesis gravidarum (HG), which occurs in a tiny proportion of all pregnancies, is the medical term for extreme nausea and vomiting. 1 About one to ten percent of all pregnancies are affected by symptoms lasting into the 20th or 22nd week of pregnancy. 2 It is possible that some women may consider terminating their pregnancies or avoiding future pregnancies if the symptoms are severe enough.…”