The association between Helicobacter pylori infection and hyperemesis gravidarum

El-Shazly, O.

doi:10.21608/aimj.2020.22069.1054

Cited by 4 publications

(8 citation statements)

References 9 publications

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“…One study (12) agrees with the present study, two groups were created from them: part 1, which consisted of 100 patients with vomiting, and part 2 (controlling group) that included 100 pregnant women without vomiting. In the first part, the authors found the mean of IgG (47.02 ± 36.51) while in the second part the mean (24.97 ± 19.58), and p-value ≤ 0.01.…”

Section: The Mean Level Of Anti-h Pylori Cag a Antibody In Sera Of Pr...supporting

confidence: 52%

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Association between Hyperemesis Gravidarum in Iraqi Women with Helicobacter pylori Infection

Rasin¹,

Aboud²

2022

The Egyptian Journal of Hospital Medicine

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Background: Helicobacter pylori are gram-negative microaerophilic bacteria, and it is considered prevalent bacteria that affect people when transmitted fecally or orally. The infection in the acute stage manifests as stomach pain and acute gastritis, but the chronic infection causes peptic ulcers and gastritis, 2% of which may progress to stomach cancer. Nausea and vomiting during pregnancy, which may occur in 75% of pregnant women in the first three months and hyperemesis gravidarum, which is extreme, persistent nausea and vomiting during pregnancy that occurs in about 2% only. Objective: Finding out how H. pylori infection relates to hyperemesis gravidarum was the main objective of this work. Subjects and Methods: One hundred blood samples were taken from people aged (16-35) years for the period from 10/1/2021 to 1/3/2022. Subjects were divided into four groups. The first group included twenty-five patients with severe H.G, the second group had twenty-three patients with mild H.G, the third group had twenty-two patients with a few H.G, and the fourth group included thirty pregnant without H.G. Measurements were made for all study groups to anti-IgA Ab, anti-IgG Ab, and anti-Cag A Ab level by enzyme-linked immunosorbent assay (ELISA) technique. Results:The statistical analysis showed a highly significant increase in the concentration of IgA in H.G compared to the control group (p > 0.01), a highly significant elevation in the concentration of IgG in H.G compared to the control group (p > 0.01), and a significant increase in concentration of anti-CagA Ab in H.G compared to control group (p>0.05). Conclusion:The present study shows that infection with Helicobacter pylori plays a role in hyperemesis gravidarum.

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Section: The Mean Level Of Anti-h Pylori Cag a Antibody In Sera Of Pr...supporting

confidence: 52%

“…It is the most common cause of hospitalization in the first half of pregnancy and second only to preterm labor for pregnancy overall. The etiology of H.G remains unknown, but a number of possible causes have been studied as endocrinal, immunological, psychological, metabolic, genetic, and even infectious such as H.pylori infection (12) .…”

Section: Introductionmentioning

confidence: 99%

Association between Hyperemesis Gravidarum in Iraqi Women with Helicobacter pylori Infection

Rasin¹,

Aboud²

2022

The Egyptian Journal of Hospital Medicine

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“…A number of different diagnostic methods, both invasive and non-invasive are available 14 . The antibody detection is cheap and easy to perform 15 , but may give false positive results. The stool antigen (Ag) test has recently become more acceptable as it is non-invasive, convenient for patients and can be performed easily even in small laboratories.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of Helicobacter pylori infection in Assiut University Hospital and medical laboratories by using non-invasive tests

Abu‐Gharbia

Agban

Hamouda

et al. 2022

Egyptian Journal of Medical Microbiology

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Helicobacter pylori is a gram negative bacterium and considered as one of the causative factors of gastritis and peptic ulceration. The exact route of transmission is still unknown. H. pylori infection was highly prevalent worldwide. Objectives: to detect H. pylori infection rate by different tests including ELIZA tests for anti H. pylori antibodies (IgM, IgG, IgA) and H. pylori antigen, to isolate H. pylori by bacterial culture, to evaluate antimicrobial susceptibility of bacteria and to estimate bacterial infection rate according to clinical symptoms of patients. Methodology: This study was done on 130 stool samples and 130 blood samples collected from 130 patients attending Gastroenterology Department of Assiut University Hospital and some special medical laboratories, collected during the period from March 2019 to February 2020. Stool samples were processed to detect H. pylori antigen titers and to isolate H. pylori bacteria, blood samples were processed to detect anti H. pylori antibodies. Antimicrobial susceptibility of H. pylori was evaluated to ten antibiotics by disc diffusion method. Results: H. pylori infection rate was 86.1% by bacterial culture, 81.5% by anti-H. pylori IgG antibodies test , 48.5% by anti-H. pylori IgA antibodies test, 13.8% by anti-H. pylori IgM antibodies test, 76.9% by H. pylori antigen test. 39.2% of H. pylori infected patients had abdominal pain. Bacterial strains were resistant to several antibiotics. Conclusion: we concluded that anti-H. pylori IgG antibodies and H. pylori antigen tests were the preferable tests for diagnosis of H. pylori infection. According to statistical analysis, these results were more reliable and valuable. Abdominal pain was the most common symptom in H. Pylori infection. ciperofloxacin and amoxicillin were the most effective antibiotics for inhibition of bacteria.

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“…Hussein (2) documented a significantly higher occurrence of H. pylori in pregnant women who suffer from HG than in women with normal pregnancies (84.4 vs. 42.2%; P = 0.003), which agreed with our results. Also, Elshazly (6) conducted a case-control study which included 200 pregnant women at 6-18 weeks of gestation divided into 2 groups: study group that included 100 pregnant women with emesis gravidarum and control group that included 100 healthy pregnant women and H. pylori IgG testing was done by ELISA. Elshazly (6) found that there was highly significant statistical difference between study group and control group as the mean value of IgG titers in 565 study group was (47.02) but in control group the mean was (24.97) with higher H. pylori seropositivity in pregnant women with emesis gravidarum which agreed with our results.…”

Section: Discussionmentioning

confidence: 99%

“…Also, Elshazly (6) conducted a case-control study which included 200 pregnant women at 6-18 weeks of gestation divided into 2 groups: study group that included 100 pregnant women with emesis gravidarum and control group that included 100 healthy pregnant women and H. pylori IgG testing was done by ELISA. Elshazly (6) found that there was highly significant statistical difference between study group and control group as the mean value of IgG titers in 565 study group was (47.02) but in control group the mean was (24.97) with higher H. pylori seropositivity in pregnant women with emesis gravidarum which agreed with our results. In a systematic review that involved 1,732 participants and controls, Golberg et al (7) observed more cases of HG in pregnant women infected with H. pylori compared to those without H. pylori (pooled OR = 4.45; 95% CI: 2.31-8.54) (2) .…”

Section: Discussionmentioning

confidence: 99%