Abstract. Little data are available regarding the association of ancylostomiasis with overt gastrointestinal bleeding. This 6-year retrospective study describes the clinical and biological profiles of unexpectedly identified ancylostomiasis in a 4-month-old baby and four adults; they presented with melena and were referred for urgent diagnostic gastrointestinal endoscopy, which confirmed numerous small intestine injuries with surrounding blood pools caused by Ancylostoma duodenale worms. Gastric erosions were also encountered in one patient. Uniquely, worm biological activities were recorded live in vivo, including mucosal invasion through a vigorous, rapid piercing process, repeated bloodsucking habits, and gut appearance during the stages of feeding, digestion, and excretion in male and female worms. In conclusion, ancylostomiasis-induced melena may occur in all ages from infants to the elderly. Worm bloodfeeding occurs after quick mucosal piercing, with blood loss being aggravated by a repeated feeding behavior. After treatment is started, bleeding stops rapidly in response to anthelmintic therapy.
ObjectivesTo detect the association between Helicobacter pylori infection and hyperemesis gravidarum among Egyptian women. Participants and methods Thirty pregnant women with hyperemesis gravidarum were recruited from the Cairo University outpatient clinics and 30 healthy pregnant volunteers with no vomiting were selected as controls. The age range in both the groups were between 18 and 39 years and the gestational age ranged from 5 to 12 weeks. All participants were subjected to full history taking, clinical examination, and ultrasound to exclude obstetric causes of hyperemesis gravidarum. Routine and special laboratory investigations were performed to test the serum for H. pylori seropositivity IgG using an enzyme-linked immunosorbent assay. ResultsThere was a highly significant difference in the H. pylori IgG antibody titer between the cases (18.1-100 U/ml) and the controls (0.9-62.7 U/ml) (Po0.01). The number of cases found to be seropositive to H. pylori IgG (100%) was higher than the number of the control individuals (86.67%), but the difference between both the groups was not statistically significant (P = 0.37). ConclusionOur results showed that there might be an association between H. pylori infection and hyperemesis gravidarum. We recommend that further studies be carried out to confirm this finding with a larger number of participants and for a longer duration of time.
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