Is There An Association Between Vitamin D and Hypertension?

Cosenso-Martin, Luciana Neves; Vilela-Martin, José Fernando

doi:10.2174/157489011795933800

Cited by 15 publications

(9 citation statements)

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“…This conclusion is primarily because of the data in study 2, which showed that vitamin D deficiency during the established phase of PKD worsened the progression of not only chronic renal injury (proteinuira, interstitial monocyte accumulation, and renal dysfunction) and markers of cardiovascular injury (cardiac enlargement and there was a trend for an exacerbation of hypertension). These data support previous published data on the adverse long-term effects of vitamin D deficiency in CKD (2,12,19), hypertension, renin gene transcription (30), and cardiac hypertrophy (8). The results of study 1 also support this hypothesis in PKD.…”

Section: Lewis+ndsupporting

confidence: 90%

Chronic effects of dietary vitamin D deficiency without increased calcium supplementation on the progression of experimental polycystic kidney disease

Rangan

Schwensen

Foster

et al. 2013

American Journal of Physiology-Renal Physiology

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Increasing evidence indicates that vitamin D deficiency exacerbates chronic kidney injury, but its effects on renal enlargement in polycystic kidney disease (PKD) are not known. In this study, male Lewis polycystic kidney disease (LPK) rats received a normal diet (ND; AIN-93G) supplemented with or without cholecalciferol (vitamin D-deficient diet, VDD; both 0.5% calcium), commenced at either postnatal week 3 (until weeks 10-20; study 1) or from week 10 (until week 20; study 2). Levels of 25-hydroxy vitamin D were reduced in groups receiving the VDD (12 ± 1 nmol/l vs. 116 ± 5 in ND; P < 0.001). In study 1, food intake and weight gain increased by ∼25% in LPK rats receiving the VDD ad libitum, and at week 20 this was associated with a mild reduction in the corrected serum calcium (SCa(2+), 7.4%) and TKW:BW ratio (8.8%), and exacerbation of proteinuria (87%) and hypertension (19%; all P < 0.05 vs. ND). When LPK rats were pair-fed for weeks 3-10, there was a further reduction in the SCa(2+) (25%) and TKW:BW ratio (22%) in the VDD group (P < 0.05 vs. ND). In study 2, the VDD did not alter food intake and body weight, reduced SCa(2+) (7.7%), worsened proteinuria (41.9%), interstitial monocyte accumulation (26.4%), renal dysfunction (21.4%), and cardiac enlargement (13.2%, all P < 0.05), but there was a trend for a reduction in the TKW:BW ratio (13%, P = 0.09). These data suggest that chronic vitamin D deficiency has adverse long-term actions on proteinuria, interstitial inflammation, renal function, and cardiovascular disease in PKD, and these negate its mild inhibitory effect on kidney enlargement.

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Section: Lewis+ndsupporting

confidence: 90%

Chronic effects of dietary vitamin D deficiency without increased calcium supplementation on the progression of experimental polycystic kidney disease

Rangan

Schwensen

Foster

et al. 2013

American Journal of Physiology-Renal Physiology

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“…Vitamin D3 has variable blood pressure (BP)-lowering effects. Vitamin D may have an independent and direct role in the regulation of BP, insulin metabolism, and dysglycemia, [5][6][7][8][9][10][11][12][13][14][15][16][17] but the results have not been consistent in prospective studies or in meta-analyses in which there has been little or no significant BP reduction. [18][19]21,23 If the vitamin D level is <30 ng/mL, the circulating plasma renin activity (PRA) levels are higher, which increases angiotensin II and elevates BP.…”

Section: Vitamin Dmentioning

confidence: 99%

“…1,7 Vitamin D reduces asymmetric dimethyl arginine, suppresses pro-inflammatory cytokines, increases nitric oxide (NO), improves endothelial function and arterial elasticity, and decreases vascular smooth-muscle hypertrophy. [8][9][10][11][12][13][14][15] The hypotensive effect of vitamin D was inversely related to the pretreatment serum levels of 1 , 25 (OH) 2 D 3 and has additive BP reduction when used concurrently with antihypertensive medication. 16 Black people have significantly higher rates of hypertension than white people, as well as lower circulating levels of 25-hydroxyvitamin D. 22 In a three-month study of placebo, 1000, 2000, or 4000 IU of cholecalciferol per day, the difference in SBP between baseline and three months was 11.7 mmHg for those receiving placebo, 2 0.66 mmHg for 1000 IU/day, 2 3.4 mmHg for 2000 IU/day, and 2 4.0 mmHg for 4000 IU/day of cholecalciferol ( 2 1.4 mmHg for each additional 1000 IU/day of cholecalciferol; P 5 0.04).…”

Section: Vitamin Dmentioning

confidence: 99%

Treatment of Hypertension with Nutrition and Nutraceutical Supplements: Part 2

HoustonMark

2019

Alternative and Complementary Therapies

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“…Vitamin D blunts cardiomyocyte hypertrophy, improves insulin sensitivity, reduces free fatty acid concentration and has regulatory effects on natriuretic peptide receptor [29]. All of these actions contribute to blood pressure control.…”

Section: Effects Of Vitamin D On Renin-angiotensin System and Blood Pmentioning

confidence: 99%

Diabetic CVD – Focus on Vitamin D

Bonakdaran

Rokni²

2012

CHAMC

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Cardiovascular disease (CVD) is the leading cause of mortality and morbidity among diabetics. Vitamin D deficiency is very common all over the world. Over last few years, vitamin D has been considered as an important regulating factor for cardiovascular health. Metabolic syndrome and obesity are highly prevalent in vitamin D deficient people. In fact all components of metabolic syndrome are affected by vitamin D. Vitamin D regulates insulin secretion and its action. It has also some controlling effect on Renin-Angiotensin system, which influences cardiomyocytes positively. Vitamin D plays a role in vascular system too. This vitamin reduces vascular calcification and inflammatory processes. Given the important role of Vitamin D in cardiovascular health, this review focuses on the impacts of vitamin D on the various CVD risk factors.

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Is There An Association Between Vitamin D and Hypertension?

Cited by 15 publications

References 0 publications

Chronic effects of dietary vitamin D deficiency without increased calcium supplementation on the progression of experimental polycystic kidney disease

Chronic effects of dietary vitamin D deficiency without increased calcium supplementation on the progression of experimental polycystic kidney disease

Treatment of Hypertension with Nutrition and Nutraceutical Supplements: Part 2

Diabetic CVD – Focus on Vitamin D

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