Treatment of Hypertension with Nutrition and Nutraceutical Supplements: Part 2

HoustonMark, C

doi:10.1089/act.2018.29197.mho

Cited by 5 publications

(4 citation statements)

References 202 publications

(475 reference statements)

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“…Resveratrol is another nutraceutical that presents an anti-hypertensive effect [171] and can be found in red grapes, and in plants that can survive harsh environmental conditions [172]. Resveratrol improves endothelial dysfunction, prevents the uncoupling of endothelial nitric oxide synthase (eNOS), increases the flow-mediated vasodilation in a dose-related manner, and blocks the effects of angiotensin II [173].…”

Section: Anti-hypertensive Activitymentioning

confidence: 99%

Nutraceutical Concepts and Dextrin-Based Delivery Systems

Hoti

Pedrazzo

Cecone

et al. 2022

IJMS

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Nutraceuticals are bioactive or chemical compounds acclaimed for their valuable biological activities and health-promoting effects. The global community is faced with many health concerns such as cancers, cardiovascular and neurodegenerative diseases, diabetes, arthritis, osteoporosis, etc. The effect of nutraceuticals is similar to pharmaceuticals, even though the term nutraceutical has no regulatory definition. The usage of nutraceuticals, to prevent and treat the aforementioned diseases, is limited by several features such as poor water solubility, low bioavailability, low stability, low permeability, low efficacy, etc. These downsides can be overcome by the application of the field of nanotechnology manipulating the properties and structures of materials at the nanometer scale. In this review, the linear and cyclic dextrin, formed during the enzymatic degradation of starch, are highlighted as highly promising nanomaterials- based drug delivery systems. The modified cyclic dextrin, cyclodextrin (CD)-based nanosponges (NSs), are well-known delivery systems of several nutraceuticals such as quercetin, curcumin, resveratrol, thyme essential oil, melatonin, and appear as a more advanced drug delivery system than modified linear dextrin. CD-based NSs prolong and control the nutraceuticals release, and display higher biocompatibility, stability, and solubility of poorly water-soluble nutraceuticals than the CD-inclusion complexes, or uncomplexed nutraceuticals. In addition, the well-explored CD-based NSs pathways, as drug delivery systems, are described. Although important progress is made in drug delivery, all the findings will serve as a source for the use of CD-based nanosystems for nutraceutical delivery. To sum up, our review introduces the extensive literature about the nutraceutical concepts, synthesis, characterization, and applications of the CD-based nano delivery systems that will further contribute to the nutraceutical delivery with more potent nanosystems based on linear dextrins.

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Section: Anti-hypertensive Activitymentioning

confidence: 99%

Nutraceutical Concepts and Dextrin-Based Delivery Systems

Hoti

Pedrazzo

Cecone

et al. 2022

IJMS

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“…3,4 One study in the United States showed that there is a role for the selected use of single and combined nutraceutical supplements, vitamins, and minerals in the treatment of hypertension as a complement to optimal nutrition and other lifestyle modifications. 7 These products are often perceived as "safe" and less likely to have side effects. The scientific research on nutraceuticals and nutrition supplements is often misinterpreted or overstretched for commercial interests because of high consumer demands.…”

Section: What Are Nutraceuticals?mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Comparison of Current Regulatory Frameworks for Nutraceuticals in Australia, Canada, Japan, and the United States.

Blaze

2021

Innov Pharm

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The nutraceutical market is growing and the demand for products is increasing. Consumers are looking for cheaper alternatives to prescription medications as well as health products to supplement their dietary intake on a regular basis. Many countries classify these products into different categories based on their health claims. The purpose of this review is to compare and contrast the differences of regulatory frameworks in countries of similar status in regard to nutraceutical products: vitamins, minerals, herbal supplements, and probiotics. This review also takes into consideration the aspects of nutraceutical safety in relation to government regulations. It is evident that further discussion is indicated with regard to the harmonization of nutraceutical product regulation in a global context in order to promote and protect public health. This literature review selected 27 documents for a review using a systematic search of internet databases and search engines including PUBMED and Google Scholar. These documents were reviewed and synthesized for data relating to nutraceutical regulation within the four different countries of focus. Outcomes included information on safety and toxicity, drug interactions, classification of products, and regulatory processes for nutraceutical product approval in each country.

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“…Functional foods, which can be used for either the treatment or the prevention of hypertension, do not cause the adverse effects of conventional drugs. The employment of these foods may contribute to the reduction of the public health expenditure destined to the cure of cardiovascular diseases (Houston, 2019a(Houston, , 2019b Bioactive peptides of animal and vegetal origin, as well as some components of functional foods, exert anti-hypertensive effects mainly through the inhibition of RAS enzymes and the increase of NO levels (Aluko, 2015a(Aluko, , 2015b(Aluko, , 2019Fritz, Vecchi, Contreras, & Recio, 2011;Martínez-Maqueda, Miralles, Recio, & Hernández-Ledesma, 2012;Quiroga, Aphalo, Nardo, & Añón, 2017;Saleh, Zhang, & Shen, 2014;Wu, Liao, & Udenigwe, 2017).…”

Section: Introductionmentioning

confidence: 99%

Effect of amaranth proteins on the RAS system. In vitro, in vivo and ex vivo assays

et al. 2020

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Treatment of Hypertension with Nutrition and Nutraceutical Supplements: Part 2

Cited by 5 publications

References 202 publications

Nutraceutical Concepts and Dextrin-Based Delivery Systems

Nutraceutical Concepts and Dextrin-Based Delivery Systems

A Comparison of Current Regulatory Frameworks for Nutraceuticals in Australia, Canada, Japan, and the United States.

Effect of amaranth proteins on the RAS system. In vitro, in vivo and ex vivo assays

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