Is there an appropriate strategy for treating co-morbid irritable bowel syndrome and bladder pain syndrome?

Dellis, Athanasios; Mozaffari, Shilan; Nikfar, Shekoufeh; Papatsoris, Athanasios; Abdollahi, Mohammad

doi:10.1080/14656566.2018.1559821

Cited by 5 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9 Also, there is evidence to suggest that improvement in one domain can lead to a favorable effect in the others. 10 The prevalence of BPS/IC is also highly variable, with different numbers being reported depending on the definition and diagnostic criteria used, the method used to investigate and characteristics of the populations studied. The reported prevalence rates range between 0.06% and 30%.…”

Section: Pbsmentioning

confidence: 99%

See 1 more Smart Citation

Current standard of care in treatment of bladder pain syndrome/interstitial cystitis

Lopez

Mangır

2021

Therapeutic Advances in Urology

View full text Add to dashboard Cite

Bladder pain syndrome/interstitial cystitis (BPS/IC) is a debilitating, systemic pain syndrome with a cardinal symptom of bladder related pain with associated systemic symptoms. It is characterized by an inflammation that partially or completely destroys the mucus membrane and can extend into the muscle layer; however, the etiology and pathogenesis is still enigmatic. It has been suggested that mast cell activation, defects in the glycosaminoglycan layer, non-functional proliferation of bladder epithelial cells, neurogenic inflammation, microvascular abnormalities in the submucosal layer, autoimmunity and infectious causes may cause BPS/IC. Available treatment options include general relaxation techniques, patient education, behavioral treatments, physical therapy, multimodal pain therapy, oral (amitriptyline, cimetidine, hydroxyzine) and intravesical treatments (heparin, lidocaine, hyaluronic acid and chondroitin sulfate), hydrodistension and other more invasive treatments. Available treatments are mostly not based on a high level of evidence. Lack of understanding of disease mechanisms has resulted in lack of targeted therapies on this area and a wealth of empirical approaches with usually inadequate efficacy. The aim of this article is to review the available evidence on the pathophysiological mechanisms of BPS/IC as they relate to available treatment options.

show abstract

Section: Pbsmentioning

confidence: 99%

“… 9 Also, there is evidence to suggest that improvement in one domain can lead to a favorable effect in the others. 10 …”

Section: Introductionmentioning

confidence: 99%

Current standard of care in treatment of bladder pain syndrome/interstitial cystitis

Lopez

Mangır

2021

Therapeutic Advances in Urology

View full text Add to dashboard Cite

show abstract

“…Currently, the philosophy for the management of IC/BPS is based on a biopsychosocial model, which is a holistic approach with the patients' active involvement [8]. Multiple treatment modalities may be necessary, and various treatments have been suggested; however, no one has demonstrated adequate efficacy in relieving symptoms [11]. According to both European (EAU) [2] and American Urological Associations (AUA) [3], the IC/BPS management strategy should include psychology, physiotherapy, drugs and more invasive interventions [2,3].…”

Section: Management Optionsmentioning

confidence: 99%