Is there a relationship between neutrophil/lymphocyte ratio and vitamin D levels in individuals over 65 years of age?

Yılmaz, Merve; Gedik, Arzu; Demir, Tevfik; Eraydın, Ayten; Çımrın, Dilek; Çömlekçi, Abdurrahman; Eraslan, Sevinç

doi:10.1530/endoabs.37.ep231

Cited by 2 publications

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“…Moreover, it was reported that vitamin D played key roles in modulating the immune responses to Streptococcus pneumonia (8), which is a common pathogen in children with CAP (9,10). In addition, a great deal of evidence has proved the relationship between vitamin D level and some immunity related markers such as neutrophil/lymphocyte radio, lymphocyte count and lymphocyte subsets (11)(12)(13). Thus, the vitamin D status may be related with the immune ability of patients with CAP and its deficiency-caused dysfunction of the immune system may be the major pathogenesis of CAP.…”

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Age-Related Vitamin D Deficiency Is Associated with the Immune Response in Children with Community-Acquired Pneumonia

Huang

Yang

2017

J Nutr Sci Vitaminol

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SummaryTo investigate vitamin D status in children with community-acquired pneumonia (CAP) and explore the association between vitamin D deficiency and the immune response in CAP children, 77 children with CAP were retrospectively analyzed. The baseline characteristics of patients were obtained from medical records. Based on the blood samples collected during diagnosis of CAP, the routine blood examination results and proportions of lymphocyte subsets were assessed. There were 71.4% (55/77) of patients with vitamin D deficiency among CAP children. The serum 25(OH)D level significantly decreased with age. Patients with vitamin D deficiency had a significantly higher neutrophil percentage, but significantly lower lymphocyte percentage and count as well as proportion of CD19 positive lymphocytes (CD191). Spearman's rho test further confirmed these positive correlations and negative correlations. Moreover, significant associations of vitamin D deficiency with age and the above immune markers were also confirmed by univariate logistic regression analysis. However, only age entered the backward stepwise regression model in multivariate analysis. Vitamin D status in CAP children was negatively associated with age. Age-related vitamin D deficiency may affect the immune response in children with CAP.

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confidence: 99%

Age-Related Vitamin D Deficiency Is Associated with the Immune Response in Children with Community-Acquired Pneumonia

Huang

Yang

2017

J Nutr Sci Vitaminol

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“…[ 20 ] According to available data, the association between vitamin D correlation and also supplementation with hematological indices is inconsistent. [ 21 22 23 24 ] More recently, a study by Stojsic Vuksanovic and colleagues found that Vitamin D3 correction in vitamin D3 deficiency and diabetes type 2/diabetic nephropathy has anti-inflammatory activity that is most pronounced on NLR and less on PLR. [ 25 ] According to an investigation by Tabatabaeizadeh and coworkers, high-dose vitamin D supplementation in adolescent girls reduces NLR.…”

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Protective effect of vitamin D supplementation on some hemogram derived inflammatory indices in normal and high-fat diet fed male wistar rats

et al. 2023

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Background: Hematological inflammatory indices are currently suggested to assess systemic inflammation. This study aims to investigate a vitamin D supplementation effect on hematological indices of inflammation in rats. Method: Forty-eight middle-aged male rats were allocated into a normal diet (ND) group (10% fat) and a high-fat diet (HFD) group (60% fat). The animals were fed for 26 weeks. After this period, each group was randomly divided into three subgroups, each of 8 rats: Group (1): animals were fed the ND and HFD containing 1 IU/g vitamin D for 4 months, group (2): animals were fed the ND and HFD containing 6 IU/g vitamin D for 4 months and group (3): animals were euthanized to evaluate the HFD effect. Serum 25-hydroxyvitamin D level, white blood cell count (WBCs), platelet count, platelet crit (PCT), mean platelet volume (MPV), platelet distribution width (PDW), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR) were measured. Results: The HFD, significantly increased body weight, PCT, PDW, PLR, NLR, and MLR and significantly reduced serum vitamin D levels compared to the ND (P < 0.05). There was a significant decrease in food intake, MPV, PDW, and NLR after vitamin D supplementation in the ND-fed group (P < 0.05). A significant reduction in platelet count, PCT, and MLR was observed after vitamin D supplementation in HFD-fed rats (P < 0.05). Conclusions: In our study, some hemogram-derived inflammatory indices were higher in the HFD-fed group, and vitamin D supplementation lowering effects on some hematological indices were seen in both ND and HFD groups.

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Is there a relationship between neutrophil/lymphocyte ratio and vitamin D levels in individuals over 65 years of age?

Cited by 2 publications

References 0 publications

Age-Related Vitamin D Deficiency Is Associated with the Immune Response in Children with Community-Acquired Pneumonia

Age-Related Vitamin D Deficiency Is Associated with the Immune Response in Children with Community-Acquired Pneumonia

Protective effect of vitamin D supplementation on some hemogram derived inflammatory indices in normal and high-fat diet fed male wistar rats

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