Age-Related Vitamin D Deficiency Is Associated with the Immune Response in Children with Community-Acquired Pneumonia

Huang, Yuancheng; Li, Fu; Yang, Ying

doi:10.3177/jnsv.63.1

Cited by 9 publications

(9 citation statements)

References 33 publications

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“…In addition, our results showed that the neutrophil‐to‐lymphocyte ratio was also not significant correlated with vitamin D in stroke patients, while a recent investigation conducted in adolescent girls has observed a significant reduction in neutrophil‐to‐lymphocyte ratio after high‐dose vitamin D supplementation (Tabatabaeizadeh et al., ). Another observational study conducted in children with community‐acquired pneumonia (CAP) has found that vitamin D deficiency had a significantly higher neutrophil‐to‐lymphocyte ratio distribution (Huang, Fu, & Yang, ). The relationship between neutrophil‐to‐lymphocyte ratio and vitamin D has not been discussed in stroke patients before the study.…”

Section: Discussionmentioning

confidence: 99%

Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients

et al. 2018

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IntroductionLow serum vitamin D levels are associated with the development of poststroke depression (PSD). Inflammatory markers play an important role in pathophysiology of PSD. The relationship between vitamin D levels and inflammatory markers has been discussed in nonstroke individuals. The purposes of this study were to explore the relationship between vitamin D levels and inflammatory markers in acute stroke patients and examine the effect of vitamin D and inflammatory markers on PSD.MethodsA total of 152 acute stroke patients were recruited. Serum levels of 25‐hydroxyvitamin D and inflammatory markers were measured by standardized laboratory methods. Depression symptoms were assessed with the 17‐item Hamilton Depression Scale (HAMD‐17). Patients with the HAMD‐17 scores ≥7 were identified to have depression symptoms.ResultsSerum vitamin D levels were negatively correlated with serum levels of interleukin‐6 and high‐sensitivity C‐reactive protein (hsCRP) (r = −.244, p = .002; r = −.231, p = .004). Multiple regression analysis showed that interleukin‐6 and hsCRP levels were associated with vitamin D levels (B = −0.355, p = .003; B = −2.085, p = .006), whereas age, height, weight, leukocyte count, neutrophil ratio, and lymphocyte rate could be omitted without changing the results. In multivariate analyses, the serum levels of vitamin D and interleukin‐6 were associated with the development of PSD after adjusted possible variables (OR = 0.976, 95% CI: 0.958–0.994, p = .009; OR = 1.029, 95% CI: 1.003–1.055, p = .027).ConclusionsSerum vitamin D levels are inversely associated with the levels of interleukin‐6 and hsCRP, suggesting a potential anti‐inflammatory role for vitamin D in stroke individuals.

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Section: Discussionmentioning

confidence: 99%

Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients

et al. 2018

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“…These findings were observed even in children with CAP. These patients with vitamin D deficiency had a significantly higher neutrophil percentage, but significantly lower lymphocyte percentage and hence vitamin D deficiency could affect the immune response in children with CAP . We did not find differences in the other biochemical determinations when the groups were stratified according to 25OHD levels.…”

Section: Discussionmentioning

confidence: 55%

Serum 25‐hydroxyvitamin D levels in hospitalized adults with community‐acquired pneumonia

Brance

Miljevic

Tizziani³

et al. 2018

Clinical Respiratory J

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“…In patients with recurrent miscarriage, the percentage of CD19 + B cells was significantly higher in the vitamin D 3 insufficiency group than in the vitamin D 3 normal group [30]. In children with community-acquired pneumonia, the positive CD19 + cells in patients with vitamin D deficiency were significantly less than that in patients without vitamin D 3 deficiency [31]. We first reported the evidence linking vitamin D level and CD19 in CHB patients.…”

Section: Discussionmentioning

confidence: 98%

The Study of Correlation between Serum Vitamin D3 Concentrations and HBV DNA Levels and Immune Response in Chronic Hepatitis Patients

Yang²,

Shen

et al. 2020

Nutrients

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Chronic hepatitis B (CHB) is a common chronic disease. Previous studies have shown a link between 25-hydroxyvitamin D3 (vitamin D3) concentration and liver disease. Hepatitis B virus (HBV) infection has been attributed to the inappropriate functioning of cell-mediated immunity. However, the effects of vitamin D3, immune cell, and HBeAg status on HBV viral load in CHB patients are still unclear. We investigated the relationship between the serum concentration of vitamin D3, percentage of immune cells in peripheral blood, and the HBV viral load of CHB patients. Sixty CHB patients were recruited, and their blood samples were collected and analyzed. Vitamin D level was measured using a chemiluminescence assay. A level of 30 ng/mL or above was defined as a vitamin D3 sufficiency. We assigned vitamin D3 status as either normal (≥30 ng/mL), insufficient (20–30 ng/mL), or deficient (<20 ng/mL). T-lymphocyte and B-lymphocyte surface markers in peripheral blood were detected using flow cytometry. The factors associated with HBV viral load were analyzed using univariate and multivariate-adjusted models. The mean serum vitamin D3 concentration in the subjects was 20.9 ± 5.6 ng/mL. Up to 88.3% of the patients were either deficient in or had insufficient vitamin D3. The gender, BMI, hepatitis B surface antigen levels, and ALT levels were significantly related to serum vitamin D3 levels. Serum vitamin D3 concentration, HBe status, HBs levels, ALT, and AST levels showed a statistically significant correlation with the HBV DNA levels. Serum vitamin D3 concentrations and hepatitis B surface antigen levels were strongly correlated with HBV DNA levels. Vitamin D3 levels were significantly associated with CD19 numbers (β:−6.2, 95% CI: −10.5). In multivariate analysis, vitamin D3 levels in the deficient and insufficient groups, and the CD8, HBeAg, and WBC counts were significantly associated with HBV DNA levels. In the immune tolerance phase of HBeAg-negative chronic HBV infection, vitamin D3 may be a modulator of immune function via CD8, CD19, and HBV DNA.

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Age-Related Vitamin D Deficiency Is Associated with the Immune Response in Children with Community-Acquired Pneumonia

Cited by 9 publications

References 33 publications

Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients

Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients

Serum 25‐hydroxyvitamin D levels in hospitalized adults with community‐acquired pneumonia

The Study of Correlation between Serum Vitamin D3 Concentrations and HBV DNA Levels and Immune Response in Chronic Hepatitis Patients

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