Is There a Relation Between Helybacter Pylori and Intestinal Metaplasia in Short Column Epitelization Up to 10 Mm in the Distal Esophagus?

Abstract

ABSTRATBackground: The presence of intestinal metaplasia in the distal esophagus (Barrett’s esophagus) is an important precursor of adenocarcinoma. Knowledge of the risk factors and the process by which the Barrett develops is very important and Helicobacter pylori (HP) can contribute to this development. Aim: To analyze the impact of HP in the gastric mucosa with intestinal metaplasia in the distal esophagus in areas of columnar epithelialization smaller than 10 mm in length and epidemiological data on prevalence Method: A retrospective study in which were included 373 consecutive patients diagnosed with columnar epithelium in the distal esophagus was done. In all, HP was investigated by urease and histology, exclusion and inclusion factors were applied and patients were divided into two groups: the first grouping the ones without histological diagnosis of Barrett’s esophagus (235-63%) and the second with it (138-37%). Results:There was no significant difference between HP and non-HP patients in relation to the probability of having intestinal metaplasia (p=0.587). When related to the general group, there was an inverse association between the bacterium and the columnar epithelia in the distal esophagus. Age (p=0.031), gender (p=0.013) and HP (p=0.613) when related together to intestinal metaplasia showed no significant relation. In isolation, when related to age and gender, regardless of HP, results confirmed that patients in more advanced age and women present a higher incidence of intestinal metaplasia. Conclusion:There is an inverse relation between HP and the areas of columnar epithelization in the distal esophagus, regardless of the presence or absence of intestinal metaplasia. Age and gender, regardless of HP, showed higher prevalence in women and in older the number of cases with intestinal metaplasia in the distal esophagus.

Is There Correlation Between Human Papillomavirus (Hpv) and Esophageal Epidermoid Carcinoma?

“…The first reports of its involvement in squamous cell carcinoma (SCC) of the esophagus appeared in 1982 with Syrjänen 18,19 . Since then, over 100 studies have attempted to relate this oncogenic virus infection -particularly the strains 16 and 18 high risk -with this esophageal neoplasia 5,15,18,21 .…”

Risk factors associated with Barrett's esophagus in hospitalized patients

“…Según las características demográficas, para diversos autores el sexo masculino es un factor de riesgo de Esófago de Barrett (4,5,6,7,8,9) . Aunque Matheus Degiovani et al, dice que el sexo femenino es un factor de riesgo de Esófago de Barret (10) . Según diversos autores la edad incrementada es un factor de riesgo (4,6,7,9,10,11,12,13,14) .…”

“…Aunque Matheus Degiovani et al, dice que el sexo femenino es un factor de riesgo de Esófago de Barret (10) . Según diversos autores la edad incrementada es un factor de riesgo (4,6,7,9,10,11,12,13,14) . Aunque Emery C Lin et al, encontró que el OR incrementa desde los 40 años constantemente hasta los 69 años donde su OR es 1.68.5…”

Review ‐ Helicobacter pylori and non‐malignant upper gastro‐intestinal diseases

“…Furthermore, a Brazilian cohort was analysed retrospectively to determine the impact of H pylori infection on the development of Barrett's esophagus. No significant difference between patients with and without H pylori infection with respect to the risk of Barrett's esophagus was detected in 235 patients with Barrett's esophagus out of total 373 subjects 6 . Focusing on the ethnic distribution of Barrett's esophagus, Sonnenberg et al performed a case control study including 52 096 cases with Barrett's esophagus, 189 235 cases with reflux esophagitis, and 152 322 controls without any clinical symptom suggesting the presence of reflux disease.…”