Is There a Place for β-Carotene/Canthaxanthin in Photochemotherapy for Psoriasis?

Macdonald, K. J. S.; Holti, G.; Marks, Janet

doi:10.1159/000249565

Cited by 18 publications

(5 citation statements)

References 6 publications

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“…For example, β-carotene is a source of retinal, the cofactor of visual photoreceptors [ 4 ]. Alongside the reported anti-cancer [ 5 ], anti-tumor, or anti-dermatosis abilities of carotenoids [ 6 , 7 ], numerous studies revealed beneficial therapeutic effects of carotenoids in human chronic diseases including the so-called canthaxanthin retinopathy, retinal dystrophy, or aplastic anemia [ 8 ]. In any case, from visual pigments to coloration of bird feathers, carotenoids come from diet and must be delivered to specific tissues and cells to perform their functions [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Soluble Cyanobacterial Carotenoprotein as a Robust Antioxidant Nanocarrier and Delivery Module

et al. 2020

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To counteract oxidative stress, antioxidants including carotenoids are highly promising, yet their exploitation is drastically limited by the poor bioavailability and fast photodestruction, whereas current delivery systems are far from being efficient. Here we demonstrate that the recently discovered nanometer-sized water-soluble carotenoprotein from Anabaena sp. PCC 7120 (termed AnaCTDH) transiently interacts with liposomes to efficiently extract carotenoids via carotenoid-mediated homodimerization, yielding violet–purple protein samples. We characterize the spectroscopic properties of the obtained pigment–protein complexes and the thermodynamics of liposome–protein carotenoid transfer and demonstrate the delivery of carotenoid echinenone from AnaCTDH into liposomes with an efficiency of up to 70 ± 3%. Most importantly, we show efficient carotenoid delivery to membranes of mammalian cells, which provides protection from reactive oxygen species (ROS). Incubation of neuroblastoma cell line Tet21N in the presence of 1 μM AnaCTDH binding echinenone decreased antimycin A ROS production by 25% (p < 0.05). The described carotenoprotein may be considered as part of modular systems for the targeted antioxidant delivery.

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Section: Introductionmentioning

confidence: 99%

Soluble Cyanobacterial Carotenoprotein as a Robust Antioxidant Nanocarrier and Delivery Module

et al. 2020

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“…Canthaxanthin is also popular as a natural skin bronzer added to cosmetics [15,16]. Experiments done on animals [8,17] including humans [3][4][5][6][7][8]18] show that even when used in small quantities such as in food colouring or cosmetics, canthaxanthin can form molecular aggregates that are deposited in the tissues, especially in the macula lutea of the eye. Although drug-related retinopathies generally affect patients taking large doses of a given drug, with canthaxanthin, the side effects were reported even without the use of high doses.…”

Section: Introductionmentioning

confidence: 99%

Interactions between canthaxanthin and lipid membranes — possible mechanisms of canthaxanthin toxicity

Sujak

2009

Cellular and Molecular Biology Letters

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Canthaxanthin (β, β-carotene 4, 4' dione) is used widely as a drug or as a food and cosmetic colorant, but it may have some undesirable effects on human health, mainly caused by the formation of crystals in the macula lutea membranes of the retina. This condition is called canthaxanthin retinopathy. It has been shown that this type of dysfunction of the eye is strongly connected with damage to the blood vessels around the place of crystal deposition. This paper is a review of the experimental data supporting the hypothesis that the interactions of canthaxanthin with the lipid membranes and the aggregation of this pigment may be the factors enhancing canthaxanthin toxicity towards the macula vascular system. All the results of the experiments that have been done on model systems such as monolayers of pure canthaxanthin and mixtures of canthaxanthin and lipids, oriented bilayers or liposomes indicate a very strong effect of canthaxanthin on the physical properties of lipid membranes, which may explain its toxic action, which leads to the further development of canthaxanthin retinopathy.

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“…We suggested [1] that use of a UVA screen on uninvolved skin of psoriatics might permit use of a higher UVA dose and more rapid clearing of lesions. In a related situation, Macdonald et al [13] reported that oral betacarotene plus canthaxanthine was not useful for routine PUVA therapy, but allowed two sensitive patients to tolerate low UVA doses. To date, increased incidence of skin cancer in PUVA patients is restricted to high-risk groups with prior exposure to carcinogens [14,15], The long-term effects of this therapy are yet to be determined.…”

Section: Why Do We Need Uva Protection?mentioning

confidence: 99%

Protection against Long Ultraviolet Radiation: Topical Browning Agents and a New Outlook

Johnson

Fusaro²

1987

Dermatology

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Is There a Place for β-Carotene/Canthaxanthin in Photochemotherapy for Psoriasis?

Cited by 18 publications

References 6 publications

Soluble Cyanobacterial Carotenoprotein as a Robust Antioxidant Nanocarrier and Delivery Module

Soluble Cyanobacterial Carotenoprotein as a Robust Antioxidant Nanocarrier and Delivery Module

Interactions between canthaxanthin and lipid membranes — possible mechanisms of canthaxanthin toxicity

Protection against Long Ultraviolet Radiation: Topical Browning Agents and a New Outlook

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