Is there a Link between Vitamin B and Multiple Sclerosis?

Nemazannikova, Natalie; Mikkelsen, Kathleen; Stojanovska, Lily; Blatch, Gregory L.; Apostolopoulos, Vasso

doi:10.2174/1573406413666170906123857

Cited by 50 publications

(26 citation statements)

References 105 publications

(92 reference statements)

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“…Pantothenic acid deficiency is rare and pwMS do not appear to have altered levels compared to healthy controls [46]. However, it is proposed to benefit pwMS through regulation of iron and oxygen transport [47]. Most of the participants who did not meet individual iron recommendations were women of childbearing age who have much higher recommendations.…”

Section: Discussionmentioning

confidence: 99%

Eating Pattern and Nutritional Risks among People with Multiple Sclerosis Following a Modified Paleolithic Diet

et al. 2020

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Preliminary studies suggest that a modified Paleolithic diet may benefit symptoms of fatigue in progressive multiple sclerosis (MS). However, this diet restricts the consumption of eggs, dairy, and gluten-containing grains, which may increase the risk of micronutrient deficiencies. Therefore, we evaluated the nutritional safety of this diet among people with progressive MS. Three nonconsecutive 24-h dietary recalls were collected from (n = 19) progressive MS participants in the final months of a diet intervention study and analyzed using Nutrition Data System for Research (NDSR) software. Food group intake was calculated, and intake of micronutrients was evaluated and compared to individual recommendations using Nutrient Adequacy Ratios (NARs). Blood was drawn at baseline and the end of the study to evaluate biomarker changes. Mean intake of fruits and vegetables exceeded nine servings/day and most participants excluded food groups. The intake of all micronutrients from food were above 100% NAR except for vitamin D (29.6 ± 34.6%), choline (73.2 ± 27.2%), and calcium (60.3 ± 22.8%), and one participant (1/19) exceeded the Tolerable Upper Limit (UL) for zinc, one (1/19) for vitamin A, and 37% (7/19) exceeded the chronic disease risk reduction (CDRR) for sodium. When intake from supplements was included in the analysis, several individuals exceeded ULs for magnesium (5/19), zinc (2/19), sodium (7/19), and vitamins A (2/19), D (9/19), C (1/19), B6 (3/19), and niacin (10/19). Serum values of vitamins D, B12, K1, K2, and folate significantly increased compared to respective baseline values, while homocysteine and magnesium values were significantly lower at 12 months. Calcium and vitamin A serum levels did not change. This modified Paleolithic diet is associated with minimal nutritional risks. However, excessive intake from supplements may be of concern.

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Section: Discussionmentioning

confidence: 99%

Eating Pattern and Nutritional Risks among People with Multiple Sclerosis Following a Modified Paleolithic Diet

et al. 2020

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“…Thiamin mean consumption was lower in the MS group (26.8%) and below recommended guidelines. Several human studies support the protective role of B vitamins in MS incidence and progression [32]. For example, thiamine deficiency causes increased chemokine ligand2 expression in neurons of the MS mice model [33].…”

Section: Discussionmentioning

confidence: 99%

New Insights on the Nutrition Status and Antioxidant Capacity in Multiple Sclerosis Patients

et al. 2019

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Background: Multiple sclerosis (MS) is a multifactorial disease with unknown etiology. It is assumed to result from interplay between genetic and environmental factors, including nutrition. We hypothesized that there are differences in nutritional parameters between MS patients and healthy controls. Methods: We examined 63 MS patients and 83 healthy controls. Nutritional status was determined by a dietary questionnaire, blood tests, quantification of cell membrane fatty acids, and serum antioxidant capacity. Results: We found that MS patients consumed a more limited diet compared with the healthy group, indicated by a lower average of 31 nutrients and by consumption levels of zinc and thiamine below the recommended daily intake. Both consumption and measured iron values were significantly lower in MS patients, with the lowest measures in the severe MS group. Long saturated fatty acids (>C16) were significantly lower in MS patients, while palmitic and palmitoleic acids were both higher. Serum total antioxidant capacity was significantly lower in the MS group compared with healthy controls, with the lowest measures in patients with severe MS. Conclusions: This study points to a possible correlation between nutritional status and MS. Understanding the clinical meaning of these findings will potentially allow for the development of future personalized dietary interventions as part of MS treatment.

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“…Vitamin B 12 acts as a modulator of gut microbiota and low levels of B 12 elevate methylmalonic acid and homocysteine, resulting in increased inflammation, reactive oxygen species and oxidative stress [ 15 ]. Hyperhomocysteinemia causes endothelial dysfunction, activation of platelet and coagulation cascades, megaloblastic anemia, disruption of myelin sheath integrity and decreased immune responses [ [27] , [28] , [29] , [30] ]. However, SARS-CoV-2 could interfere with vitamin B 12 metabolism, thus impairing intestinal microbial proliferation.…”

Section: Can Vitamin B Be Used To Manage Covid-19?mentioning

confidence: 99%