Be well: A potential role for vitamin B in COVID-19

Shakoor, Hira; Feehan, Jack; Mikkelsen, Kathleen; Dhaheri, Ayesha S. Al; Ali, Habiba I.; Platat, Carine; Ismail, Leila Cheikh; Stojanovska, Lily; Apostolopoulos, Vasso

doi:10.1016/j.maturitas.2020.08.007

Cited by 135 publications

(136 citation statements)

References 36 publications

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“…Recent studies revealed that vitamins reduce the risk of pneumonia and other viral respiratory tract infections [28]. The vitamins also exhibit direct inhibition of viral replication or with immunomodulatory or anti-inflammatory means [29][30][31]. The computational approach, molecular docking appears as a tool for screening new antiviral compounds.…”

Section: Resultsmentioning

confidence: 99%

Unravelling Vitamins as Wonder Molecules for Covid-19 Management via Structure-based Virtual Screening

Pandya

Shah

Menamadathil

et al. 2021

Preprint

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The emergence situation of coronavirus disease 2019 (COVID-19) pandemic has realised the global scientific communities to develop strategies for immediate priorities and long-term approaches for utilization of existing knowledge and resources which can be diverted to pandemic preparedness planning. Lack of proper vaccine candidate and therapeutic management has accelerated the researchers to repurpose the existing drugs with known preclinical and toxicity profiles, which can easily enter Phase 3 or 4 or can be used directly in clinical settings. We focused to justify even exploration of supplements, nutrients and vitamins to dampen the disease burden of the current pandemic may play a crucial role for its management. We have explored structure based virtual screening of 15 vitamins against non-structural (NSP3, NSP5, ORF7a, NSP12, ORF3a), structural (Spike & Hemagglutinin esterase) and host protein furin. The in silico analysis exhibited that vitamin B12, Vitamin B9, Vitamin D3 determined suitable binding while vitamin B15 manifested remarkable H-bond interactions with all targets. Vitamin B12 bestowed the lowest energies with human furin and SARS-COV-2 RNA dependent RNA polymerase. Furin mediated cleavage of the viral spike glycoprotein is directly related to enhanced virulence of SARS-CoV-2. In contrast to these, vitamin B12 showed zero affinity with SARS-CoV-2 spike protein. These upshots intimate that Vitamin B12 could be the wonder molecule to shrink the virulence by hindering the furin mediated entry of spike to host cell. These identified molecules may effectively assist in SARS-CoV-2 therapeutic management to boost the immunity by inhibiting the virus imparting relief in lung inflammation.

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Section: Resultsmentioning

confidence: 99%

Unravelling Vitamins as Wonder Molecules for Covid-19 Management via Structure-based Virtual Screening

Pandya

Shah

Menamadathil

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Recent studies suggested a possible association between folic acid and SARS-CoV−2. An inhibitory interaction between folic acid and the proteolytic protein furin, which was documented to promote activation of the coronavirus, was recently demonstrated [ 33 , 34 ]. Additionally, folic acid and its derivatives were found to have a direct anti-SARS-CoV−2 effect [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Folate Levels in Patients Hospitalized with Coronavirus Disease 2019

et al. 2021

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We aimed to investigate the prevalence of decreased folate levels in patients hospitalized with Coronavirus Disease 2019 (COVID-19) and evaluate their outcome and the prognostic signifi-cance associated with its different levels. In this retrospective cohort study, data were obtained from the electronic medical records at the Sheba Medical Center. Folic acid levels were available in 333 out of 1020 consecutive patients diagnosed with COVID-19 infection hospitalized from January 2020 to November 2020. Thirty-eight (11.4%) of the 333 patients comprising the present study population had low folate levels. No significant difference was found in the incidence of acute kidney injury, hypoxemia, invasive ventilation, length of hospital stay, and mortality be-tween patients with decreased and normal-range folate levels. When sub-dividing the study population according to quartiles of folate levels, similar findings were observed. In conclusion, decreased serum folate levels are common among hospitalized patients with COVID-19, but there was no association between serum folate levels and clinical outcomes. Due to the important role of folate in cell metabolism and the potential pathologic impact when deficient, a follow-up of folate levels or possible supplementation should be encouraged in hospitalized COVID-19 patients. Fur-ther studies are required to assess the prevalence and consequences of folate deficiency in COVID-19 patients.

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“…[48,49] High-doses of thiamine (B1) have been recommended for COVID-19 patients. [50] Furthermore, supplementation of niacin (B3) can help control the inflammatory process (generally caused by interleukin 6) in patients with COVID-19. [51] Another vitamin, folic acid, can be prescribed as an adjunct treatment for COVID-19 and respiratory disease in the early stages, [52] because tetrahydrofolic acid and 5-methyl tetrahydrofolic acid have strong and stable binding affinities against the SARS-CoV-2.…”

Section: Vitamins Minerals and Covid-19mentioning

confidence: 99%

COVID-19 and Fast Foods Consumption: a Review

Bohlouli

Moravejolahkami

Dashti

et al. 2021

International Journal of Food Properties

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While all groups are affected by the COVID-19 pandemic, the aged people as well as those with underlying chronic medical conditions are at the greatest risk. The higher adherence to refined carbohydrate diets, sweats, and saturated fats contributes to the prevalence of obesity and type 2 diabetes; these disorders increase the risk for severe COVID-19 morbidity and mortality. Fast food consumption activates the intrinsic immune system and impairs adaptive immunity, leading to chronic inflammation and impaired host defence against viruses. Furthermore, inflammatory responses caused by COVID-19 may have long-term costs in survived individuals, leading to chronic disorders such as dementia and neurodegenerative disease through neuroinflammatory mechanisms that are related to an unhealthy diet. Therefore, now more than ever, wider access to healthy foods should be a main concern and individuals should be aware of healthy eating habits to reduce COVID-19 complications.

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Be well: A potential role for vitamin B in COVID-19

Cited by 135 publications

References 36 publications

Unravelling Vitamins as Wonder Molecules for Covid-19 Management via Structure-based Virtual Screening

Unravelling Vitamins as Wonder Molecules for Covid-19 Management via Structure-based Virtual Screening

Folate Levels in Patients Hospitalized with Coronavirus Disease 2019

COVID-19 and Fast Foods Consumption: a Review

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