Is there a correlation between HPV and urinary bladder carcinoma?

Shaker, Olfat G.; Hammam, Olfat; Wishahi, Mohamed

doi:10.1016/j.biopha.2012.10.019

Cited by 25 publications

(30 citation statements)

References 49 publications

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“…In one study HPV genetic material was present in 7 of 10 cases of schistosomal cystitis with dysplasia, but in none of 5 cases with nonspecific cystitis. However, there was no correlation between high or low risk HPV type and urothelial neoplasia, suggesting that any HPV involvement in schistosome-associated bladder cancer must involve different molecular mechanisms than in uterine cervix or upper aerodigestive mucosa tumorigenesis [35]. Other studies examining a multitude of non-bilharziasis associated urothelial neoplasms have not revealed the presence of HPV infection [11], [36], [37].…”

Section: Discussionmentioning

confidence: 92%

The Expression Patterns of p53 and p16 and an Analysis of a Possible Role of HPV in Primary Adenocarcinoma of the Urinary Bladder

et al. 2014

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BackgroundPrimary adenocarcinoma of the urinary bladder is rare. The molecular and cellular events leading to its pathogenesis are not well delineated. The goal of this study was to investigate p53 and p16 expression, as well as HPV status, in a relatively large series of primary bladder adenocarcinomas.Materials and MethodsThirty six cases of urinary bladder adenocarcinoma were chosen from participating institutions. The diagnosis and available clinical history were reviewed in each case. Immunostains for p53, p16 and HPV and high-risk and low-risk HPV-ISH were performed on all tumors.ResultsPatients had an average age of 61 years with a male predominance (1.5∶1 male∶female ratio). The average tumor size in cystectomy specimens was 4.3 cm. Of the cases managed by transurethral resection, 40% were pT2 at the time of diagnosis. In cystectomy specimens, 77% were either pT3 or pT4. Strong nuclear p16 expression was seen in 67% of all cases and p53 expression was present in 58% of the cases. Expression of both markers was seen in 33% of cases. Expression of p16 or p53 alone was present in 12 (33%) and 9 (25%) cases, respectively. Neither marker was expressed in only 3 (8%) of the tumors. No significant correlation between clinical variables and any of the markers we studied was identified. No HPV infection was detected in any case.ConclusionsExpression of p53 and/or p16 is very common in urinary bladder adenocarcinoma. These findings implicate a high likelihood that alterations in these cell cycle proteins contribute to the pathogenesis of these tumors. Despite frequent immunohistochemical labeling for p16, no evidence of HPV infection was found.

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Section: Discussionmentioning

confidence: 92%

The Expression Patterns of p53 and p16 and an Analysis of a Possible Role of HPV in Primary Adenocarcinoma of the Urinary Bladder

et al. 2014

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“…Several groups have investigated a possible role for human papillomavirus (HPV) involvement in schistosomal bladder cancer, with some studies finding potential associations [11,84,85] whereas samples from patient groups from other geographic regions do not show evidence for the HPV strains studied [86]. The definitive demonstration of HPV or other viral involvement in the etiology of schistosomal bladder cancer may be complicated by the possibility of “hit-and-run” scenarios where viruses transiently affect the genetic or epigenetic states of cells in a pro-tumorigenic manner, yet may be lost from subsequent tumors if viral persistence is not necessary for tumor survival [87].…”

Section: The Role Of Co-infections In Carcinogenesismentioning

confidence: 99%

Controversies and challenges in research on urogenital schistosomiasis-associated bladder cancer

Honeycutt

Hammam

et al. 2014

Trends in Parasitology

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Urogenital schistosomiasis, infection with Schistosoma haematobium, is linked to increased risk for the development of bladder cancer, but the importance of various mechanisms responsible for this association remains unclear, in part due to lack of sufficient and appropriate animal models. New advances in the study of this parasite, bladder regenerative processes, and human schistosomal bladder cancers may shed new light on the complex biological processes that connect S. haematobium infection to bladder carcinogenesis.

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“…[163,166,167] The controversy continues with the inverted papiloma of the urinary tract and urothelial carcinomas. In some reports HPV is associated with inverted papilloma of the urinary bladder [168] and urothelial carcinomas, [167,169] but in the others no association was reported. [170,171] HPVs, especially HPV16 and HPV18, were detected mostly in low grade (grade 1) tumours and never have they been reported for grade 3 carcinomas.…”

Section: Bladder Cancermentioning

confidence: 99%

The role of human papillomaviruses in cancer progression

Tulay¹,

Serakıncı²

2016

JCMT

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The importance of human papillomavirus (HPV) infection and its role in the progress of cancer have been widely evaluated. The understanding of HPV association with certain cancers, such as cervical cancer, is very well established. A big step forward in the prevention of HPV associated cancers with the use of early detection by screening strategies has also been taken. In the last decade, development of HPV vaccination has reduced the number of cases in HPV infections and infection induced cancers. In this report, we review the HPV pathogenesis and highlight the mechanism of HPV involvement in cancer development.

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Is there a correlation between HPV and urinary bladder carcinoma?

Cited by 25 publications

References 49 publications

The Expression Patterns of p53 and p16 and an Analysis of a Possible Role of HPV in Primary Adenocarcinoma of the Urinary Bladder

The Expression Patterns of p53 and p16 and an Analysis of a Possible Role of HPV in Primary Adenocarcinoma of the Urinary Bladder

Controversies and challenges in research on urogenital schistosomiasis-associated bladder cancer

The role of human papillomaviruses in cancer progression

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