Controversies and challenges in research on urogenital schistosomiasis-associated bladder cancer

Honeycutt, Jared; Hammam, Olfat; Fu, Chi Ling; Hsieh, Michael H.

doi:10.1016/j.pt.2014.05.004

Cited by 80 publications

(85 citation statements)

References 103 publications

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“…The carcinogenic effect of this estrogen-DNA adduct mediated pathway could partially explain the link between UGS and SCC of the bladder. UGS induced SCC is clearly multifactorial, however, in like fashion to other infection-and inflammation-related related cancers at large [23][24][25][26][27]. The chromatograms of urine of the UGS cases exhibited few metabolites with high mass range, which we speculate results from chemical processes, including hydrolysis occurring in the aqueous system.…”

Section: Discussionmentioning

confidence: 88%

“…The severity and frequency of the sequelae of UGS and of its complications are related to the intensity and duration of the infection [21][22][23]. Moreover, infection with S. haematobium is classified as a Group 1 biological carcinogen by the World Health Organization (WHO)'s International Agency for Research on Cancer (WHO IARC) [24] although the cellular and/or molecular mechanisms linking S. haematobium infection with carcinogenesis have yet to be defined [25,26]. It has been known for several decades that bladder cancer, especially squamous cell carcinoma (SCC), a distinctly malignant, poorly differentiated neuroendocrine neoplasm [16], was geographically associated with UGS, i.e.…”

Section: Introductionmentioning

confidence: 99%

“…areas endemic for schistosomiasis haematobia [20,24,27]. In regions with high worm burdens, and a high risk of exposure to S. haematobium infection, SCC is the most frequent histological type, whereas urothelial cell carcinoma (UCC) is predominant in nonendemic locations [22][23][24]26,28,29].…”

Section: Introductionmentioning

confidence: 99%

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Estrogen-like metabolites and DNA-adducts in urogenital schistosomiasis-associated bladder cancer

Gouveia¹,

Santos²,

Brindley³

et al. 2015

Cancer Letters

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Estrogen-like metabolites and DNA-adducts in urogenital schistosomiasis-associated bladder cancer

Gouveia¹,

Santos²,

Brindley³

et al. 2015

Cancer Letters

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“…Whereas carcinogenesis may be induced by other factors, 76,77 this is a plausible route to UGS-induced SCC. Pathways for formation of these carcinogenic metabolites with parasite origin are not yet fully understood.…”

Section: Future Perspectivesmentioning

confidence: 99%

The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer

et al. 2017

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Urogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke Schistosoma haematobium, the infectious agent of urogenital schistosomiasis, releases estradiol-like metabolites. These kind of compounds have been implicated in other cancers. Aiming for enhanced understanding of the pathogenesis of the urogenital schistosomiasis-induced bladder cancer, here we review, interpret, and discuss findings of estradiol-like metabolites detected in both the parasite and in the human urine during urogenital schistosomiasis. Moreover, we predict pathways and enzymes that are involved in the production of these metabolites emphasizing their potential effects on the dysregulation of the tumor suppressor gene p53 expression during urogenital schistosomiasis. Enhanced understanding of these potential carcinogens may not only shed light on urogenital schistosomiasis-induced neoplasia of the bladder, but would also facilitate development of interventions and biomarkers for this and other infection-associated cancers at large.

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“…We did not find a case with a prior radiation to the pelvic organs, but to the head and neck region for lymphomas and retinoblastomas suggesting that local radiotherapy plays no major role in the pathogenesis of bladder leiomyosarcoma. A schistosomiasis of the urinary bladder as a documented risk factor for the development of bladder tumors was observed in 1 patient [20,84]. The reviewed sarcomas were diagnosed at a median age of 52 years, with a male to female ratio of 1.4: 1.…”

Section: Discussionmentioning

confidence: 99%

Leiomyosarcoma of the Urinary Bladder in Adult Patients: A Systematic Review of the Literature and Meta-Analysis

et al. 2018

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Purpose: Leiomyosarcoma of the urinary bladder is exceedingly rare. Most clinicians come across only a few cases during their career, and information regarding treatment and outcome is scattered in the scientific literature. Interested clinicians and patients have to undertake troublesome search for treatment and outcome information. Material and methods: We performed a systematic review of the literature using the PubMed and Web of Science databases and included all identified cases published in English language between 1970 and June 2018 into a meta-analysis. Prior to the literature search, key questions were formulated and with the data obtained, answers to these questions should be derived. Results: We analyzed clinical data of 210 cases of urinary bladder leiomyosarcoma revealed by this review and seen in our institution. The mean age of patients was 52 years. The majority (75%) of the tumors was classified as high-grade sarcomas. We found no report of a prior radiation therapy to the pelvic organs, but some authors suggested an association between cyclophosphamide treatment and the development of bladder leiomyosarcoma, especially in patients with retinoblastoma. For the whole sample, we determined 5- and 10-year cancer-specific cumulative mortality rates of 38 and 50%. Patients with high-grade sarcomas had a trend toward a higher mortality compared with low-grade tumors (p = 0.0280). The most promising treatment option seems to be surgery (radical or partial cystectomy) with negative resection margins, possibly supplemented by chemotherapy or radiation. Conclusion: About half of patients with bladder leiomyosarcoma survived on the long run. Low-grade tumors may have a better outcome with, nevertheless, countable long-term mortality. For better assessment of that rare bladder tumor, its best treatment options, and the influence of neoadjuvant or adjuvant therapies on the outcome of patients, a larger series with long-term survival data is required.

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Controversies and challenges in research on urogenital schistosomiasis-associated bladder cancer

Cited by 80 publications

References 103 publications

Estrogen-like metabolites and DNA-adducts in urogenital schistosomiasis-associated bladder cancer

Estrogen-like metabolites and DNA-adducts in urogenital schistosomiasis-associated bladder cancer

The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer

Leiomyosarcoma of the Urinary Bladder in Adult Patients: A Systematic Review of the Literature and Meta-Analysis

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