Is the erythrocyte membrane fatty acid composition a valid index of skeletal muscle membrane fatty acid composition?

Marino, L.; Maffettone, Ada; Cipriano, Paola; Sacco, Margherita; Palma, Roberto Di; Amato, Bruno; Quarto, Gennaro; Riccardi, Gabriele; Rivellese, Angela Albarosa

doi:10.1053/meta.2000.8616

Cited by 25 publications

(15 citation statements)

References 17 publications

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“…According to our linear models, changes in membrane fatty acid composition do not play an independent role in the improvements in insulin sensitivity in our participants. It is possible that phospholipid composition in erythrocytes does not reflect phospholipid composition in muscle [39] and/or the study duration of 8 weeks was too short to allow a full steady state to be achieved with respect to phospholipid fatty acid composition of skeletal muscle, liver and depot fat.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults

et al. 2008

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Aims/hypothesis Epidemiological research indicates that long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) improve insulin resistance. The aim of this study was to investigate the effects of seafood consumption on insulin resistance in overweight participants during energy restriction. Methods In this 8 week dietary intervention, 324 participants (20-40 years, BMI 27.5-32.5 kg/m 2 , from Iceland, Spain and Ireland) were randomised by computer to one of four energyrestricted diets (−30E%) of identical macronutrient composition but different LC n-3 PUFA content: control (n=80; no seafood; single-blinded); lean fish (n=80; 150 g cod, three times/week); fatty fish (n=84; 150 g salmon, three times/ week); (4) fish oil (n=80; daily docosahexaenoic/eicosapentaenoic acid capsules, no other seafood; single-blinded). Fasting glucose, insulin, adiponectin, plasma triacylglycerol and fatty acids in erythrocyte membrane were measured at baseline and endpoint. Insulin resistance was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). Linear models with fixed effects and covariates were used to investigate the effects of seafood consumption on fasting insulin and HOMA-IR at endpoint in comparison with the control group. Results Of the participants, 278 (86%) completed the intervention. Fish oil intake was a significant predictor of fasting insulin and insulin resistance after 8 weeks, and this finding remained significant even after including weight loss, triacylglycerol reduction, increased LC n-3 PUFA in membranes or adiponectin changes as covariates in the statistical analysis. Weight loss was also a significant predictor of improvements. Conclusions/interpretation LC n-3 PUFA consumption during energy reduction exerts positive effects on insulin resistance in young overweight individuals, independently from changes in body weight, triacylglycerol, erythrocyte membrane or adiponectin.Trial registration: ClinicalTrials.gov NCT00315770.

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Section: Discussionmentioning

confidence: 99%

Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults

et al. 2008

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“…Fatty acids (FA) composition of membrane phospholipids such as sphingomyelin (SM), phosphatidylethanolamine (PE) and phosphatidylcholine (PC) are tissue specific [7] but are affected by the composition of the dietary fat [8]. Changes in the fatty acids composition of erythrocyte membrane, which are easily accessible cells, reflects changes in that of membrane phospholipids of less accessible tissues [9].…”

Section: Open    Accessmentioning

confidence: 99%

Effect of Omega-3 Fatty Acids on Erythrocyte Membrane in Diabetic Rats

Hussein¹,

Mostafa²,

El-Waseef³

et al. 2011

Macedonian Journal of Medical Sciences

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“…To our knowledge, only two cross-sectional studies (16,17) have addressed that issue. The first study (16) supported the hypothesis that the fatty acid composition of membranes differed from tissue to tissue, whereas the second study (17) found a statistically significant positive correlation between fatty acid composition in erythrocyte and muscle cell membranes. The results from the latter study suggest that the composition of human erythrocyte membrane fatty acid may reflect fatty acid composition in other body tissues.…”

Section: Introductionmentioning

confidence: 99%

Erythrocyte Membrane Fatty Acids and Subsequent Breast Cancer: a Prospective Italian Study

Pala¹,

Krogh²,

Muti³

et al. 2001

JNCI Journal of the National Cancer Institute

189

165

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Background:The relationship between erythrocyte membrane fatty acids and postmenopausal breast cancer risk was analyzed previously only by retrospective studies, which suggested a protective effect of increased saturation index (SI), i.e., the ratio of membrane stearic to oleic acid. We investigated the relationships in a prospective study of hormones, diet, and prediagnostic breast cancer (the ORDET study) conducted in northern Italy. Methods: A total of 4052 postmenopausal women were followed for an average of 5.5 years; 71 cases of invasive breast cancer were identified. For each case subject, two matched control subjects were chosen randomly from among cohort members. The various fatty acids in erythrocyte membranes were measured as a percentage of total fatty acids. Conditional logistic regression analysis evaluated the association between membrane fatty acid composition and breast cancer risk. The SI, which is influenced by the activity of the enzyme delta 9 desaturase (⌬9-d), was also investigated. All statistical tests were twosided. Results: Oleic (highest versus lowest tertile of percentage of total fatty acids, odds ratio [OR] = 2.79; 95% confidence interval [CI] = 1.24 to 6.28) and monounsaturated fatty acids (highest to lowest tertile, OR = 5.21; 95% CI = 1.95 to 13.91) were positively associated with breast cancer risk. The SI (highest to lowest tertile, OR = 0.29; 95% CI = 0.13 to 0.64) was inversely associated with breast cancer risk. The analysis suggested an inverse association between total polyunsaturated fatty acids and breast cancer risk, but individual polyunsaturated fatty acids behaved differently. There was no association between saturated fatty acids and breast cancer risk. Conclusions: We have found that monounsaturated fats and SI in erythrocyte membranes

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Is the erythrocyte membrane fatty acid composition a valid index of skeletal muscle membrane fatty acid composition?

Cited by 25 publications

References 17 publications

Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults

Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults

Effect of Omega-3 Fatty Acids on Erythrocyte Membrane in Diabetic Rats

Erythrocyte Membrane Fatty Acids and Subsequent Breast Cancer: a Prospective Italian Study

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