Is routine histopathological analysis of nasal polyposis specimens necessary?

Yaman, Hüseyin; Alkan, Nihal; Yılmaz, Süleyman; Koç, Sema; Belada, Abdullah

doi:10.1007/s00405-011-1534-x

Cited by 22 publications

(24 citation statements)

References 14 publications

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“…[24] concluded that in cases of unilateral polyps, histopathological examination of the entire material is mandatory. However, they stated that routine histological examination of bilateral nasal polyposis might possibly not be necessary in cases where the clinical assessment very clearly has not disclosed any unusual or suspicious signs.…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Vitamin D Among Patients with Nasal Polyps in Bolu,Turkey

Apuhan¹,

Buğdaycı²,

Alçelik³

et al. 2012

J Aller Ther

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Background: Nasal polyps are common chronic non-neoplastic growths of the nasal or paranasal sinus mucosa. Vitamin D deficiency, in particular, has been linked to a high rate of both infectious and inflammatory diseases, including those of the upper and lower airways. Aim:In this study, we analyzed the association between plasma 25-hydroxy vitamin D (25[OH]D) levels in patients with nasal polyps. Material and method:Sixty patients (31 male and 29 female), whose ages ranged from 18 to 55 years, were enrolled in this prospective, clinical study.Results: Serum levels of 25 (OH) vitamin D were measured by using a 25 (OH) vitamin D enzyme immune assay kit. There were no statistically significant differences between the control and study groups in plasma 25(OH) D levels, gender, or age (p<0.05). Lung Disorders/Injury both graders and then averaged to yield a mean CT bone erosion score for each patient. The graders were blinded to age, race, gender, and 25-hydroxy vitamin D status of the patients [10,11]. Conclusions

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Section: Discussionmentioning

confidence: 99%

Serum Levels of Vitamin D Among Patients with Nasal Polyps in Bolu,Turkey

Apuhan¹,

Buğdaycı²,

Alçelik³

et al. 2012

J Aller Ther

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“…Therefore, there is a consensus that pathological analysis of nasal polyp specimens is necessary. [7][8][9] However, whether routine histopathologic examination is required in cases of bilateral, benign-appearing nasal polyps has not been resolved. 5,6,8,9 In his evaluation of more than 2000 bilateral nasal polyp specimens, Garavello identified inverted papilloma in 7 cases and adenocarcinoma in 1 case.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9] However, whether routine histopathologic examination is required in cases of bilateral, benign-appearing nasal polyps has not been resolved. 5,6,8,9 In his evaluation of more than 2000 bilateral nasal polyp specimens, Garavello identified inverted papilloma in 7 cases and adenocarcinoma in 1 case. 5 In their study that conducted postoperative histopathological evaluation on 200 bilateral nasal-polyp specimens, Busaba et al reported that 9 (4.5%) had an unexpected diagnosis.…”

Section: Discussionmentioning

confidence: 99%

A Case of Sarcomatoid Carcinoma in A Patient with Bilateral Sinonasal Polyps

Tatar¹,

Yörük²,

Atalay³

et al. 2016

Turkish J Rhinology

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arcomatoid carcinoma, which is variously called pseudosarcoma, pseudosarcomatous squamous cell carcinoma, pseudosarcoma associated with squamous cell carcinoma, spindle cell squamous cell carcinoma, and polypoid carcinoma, is a rare, highly malignant variant of squamous cell carcinoma (SCC).1,2 This tumor is characterized by the sarcomatoid proliferation of in-situ and/or invasive, malignant spindle cells together with the SCC component.2 The tumor is often observed in the larynx and pharynx in the head and neck, but it has been reported in the sinonasal tract in only a few cases. A AB BS S T TR RA AC CT T Sarcomatoid carcinoma is a highly malignant variant of squamous cell carcinoma and very rarely seen in the sinonasal cavity. This article reports a case of clinic presentation of bilateral nasal polyps in which sarcomatoid carcinoma was determined by the postoperative histopathological evaluation. The initial presentation, which was compatible with nasal polyps filling the bilateral middle meatus, was diagnosed by endoscopic examination in a 52-year-old female patient who had had a 3-year history of complaints of nasal obstruction and who had had nasal polypectomy surgery 2 years before. The preoperative computed tomography of the paranasal sinuses observed common inflammatory mucosal changes in the bilateral ethmoid, sphenoid, and right maxillary sinus and common soft-tissue densities in the bilateral nasal cavities. Endoscopic sinus surgery was performed, and the mass was excised. The patient's final pathologic result was reported as squamous cell carcinoma with pseudosarcomatous stroma (sarcomatoid carcinoma).K Ke ey y W Wo or rd ds s: : Carcinoma; nasal polyps; squamous cell carcinoma; nasal cavity Ö ÖZ ZE ET T Skuamoz hücreli karsinomun ileri düzeyde malign varyantı olan sarkomatoid karsinom sinonasal kavitede çok nadir görülen bir tümördür. Bu makalede bilateral nazal polip kliniğiyle başvuran ve postoperatif histopatolojik değerlendirmede sarcomatoid karsinom tespit edilen bir olgu sunulmuştur. Üç yıldır burun tıkanıklığı şikayeti olduğunu ve 2 sene önce nasal polipektomi ameliyatı olduğunu belirten 52 yaşında kadın hastanın endoskopik muayenesinde bilateral orta meayı dolduran nasal polip ile uyumlu görünüm tespit edildi. Preoperatif paranazal sinüs BT de bilateral ethmoidde, sfenoid ve sağ maksiler sinüste yaygın enflamatuvar mukozal değişiklikler ve bilateral nazal kavitede yaygın yumuşak doku dansiteleri gözlendi. Endoscopic sinüs cerrahisi yapıldı ve kitle çıkarıldı. Hastanın nihai patoloji sonucu psödosarkomatöz stromalı skuamöz hücreli karsinom (sarkomatoid karsinom) olarak raporlandı.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Karsinoma; nazal polip; skuamöz hücre karsinomu; nazal kavite T Tu ur rk ki is sh h J J R Rh hi in no ol lo og gy y 2 20 01 16 6; ;5 5( (1 1)

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“…En ese sentido, los cuadros de rinosinusitis crónica, que corresponden a los más frecuentes, presentan características clínicas particulares como engrosamiento mucoso difuso maxiloetmoidal, frontoetmoidal o velamientos bilaterales de senos paranasales 4 . A diferencia de lo anterior, la patología tumoral con frecuencia se presenta en las fosas nasales de forma asimétrica, con calcificaciones en patología fúngica o con erosión ósea más destrucción de tejido circundante en enfermedad maligna 6 .…”

Section: Discussionunclassified

“…El estudio histopatológico de muestras obtenidas mediante CENS es rutinaria en muchos centros hospitalarios 3 , sin embargo, los reportes de sus resultados y el análisis de su utilidad en esta práctica son escasos en la literatura científica 3 . Es por ello que actualmente no existe un consenso acerca de las circunstancias en que su utilidad se encontraría realmente justificada, sobre todo frente a altas sospechas de patología benigna 3,4 . En general, ésta es realizada para prevenir la pérdida de diagnósticos ocultos principalmente con histología maligna y por razones médico-legales 5 .…”

Section: Introductionunclassified

Correlación diagnóstico clínico e histopatológico en cirugía endoscópica nasosinusal

et al. 2012

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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Introducción: El estudio histopatológico de muestras obtenidas mediante cirugía endoscópica nasosinusal (CENS) es rutinaria en muchos centros hospitalarios, sin embargo, los reportes de sus resultados y el análisis de su real utilidad clínica son escasos en la literatura publicada.Objetivos: Describir y analizar el estudio de la anatomía patológica obtenida mediante CENS y conocer la correlación entre el diagnóstico clínico y la histopatología.Material y método: Se realizó un estudio descriptivo retrospectivo mediante revisión de fichas clínicas y recolección de datos anatomopatológicos, intervenciones por CENS en el Hospital Clínico Universidad de Chile.Resultados: El mayor porcentaje de los resultados histopatológicos fueron diferentes formas de rinosinusutis crónica (RSC) representando 65,67% (RSC simple, alérgica, poliposa alérgica y no alérgica). Entre los hallazgos con menor frecuencia destacan: papiloma invertido (4,9%), pólipo antrocoanal (9,31%), rinosinusitis fúngica no invasiva (2,45%) y 7 casos de patología maligna. Con respecto a la correlación clínica e histopatológica, se encontró para RSC una concordancia del 92,15%, para RSC poliposa del 95,94% y en pólipos antrocoanales 85,71%.Conclusiones: La mayoría de los resultados obtenidos fueron distintas formas de inflamación crónica de la mucosa nasosinusal. Se encontró una fuerte correlación entre el diagnóstico clínico y la histopatología, sin embargo, la aparición no excepcional de patología maligna inclina la conducta hacia el uso rutinario de solicitud de biopsia.Palabras clave: Cirugía endoscópica nasal, estudio anatomopatológico. ABSTRACTIntroduction: Histopathological examination of samples obtained by endoscopic sinus surgery (ESS) is routine in many hospitals, however, results reports and effective analysis of its clinical utility are scarce in the literature.Aim: To describe and analyze the pathological study in ESS. Furthermore, recognize the correlation between histopathology and clinical diagnosis.

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Is routine histopathological analysis of nasal polyposis specimens necessary?

Cited by 22 publications

References 14 publications

Serum Levels of Vitamin D Among Patients with Nasal Polyps in Bolu,Turkey

Serum Levels of Vitamin D Among Patients with Nasal Polyps in Bolu,Turkey

A Case of Sarcomatoid Carcinoma in A Patient with Bilateral Sinonasal Polyps

Correlación diagnóstico clínico e histopatológico en cirugía endoscópica nasosinusal

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