Is propofol a safe and effective sedative for relocating hip prostheses?

Abstract

Significant adverse effects of propofol in this case series were uncommon (12/98 patients) and readily countered. This case series suggests that propofol is a safe and effective sedative for relocating hip prostheses.

Safety and efficacy of procedural sedation with propofol in a country with a young emergency medicine training program

“…To date we have only found one report of a patient requiring intubation while receiving propofol for deep sedation in the ED, this patient suffered no sequelae [6]. The SE rate of 19% in our study is consistent with the reports in the literature [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Respiratory events in studies using propofol for sedation in an ED setting range from 1.4% [3] to almost 60% [11], the latter included only ASA All variables are in whole numbers (%).…”

“…However a much higher desaturation rate was noted with midazolam suggesting that propofol might be a safer agent for use in the elderly [22]. In contrast to Mathieu et al [9] none of our patients required pressors.…”

“…Procedural sedation and analgesia (PSA) has been shown to be a safe and effective method allowing patients to undergo painful procedures in emergency departments (EDs) in countries that recognize emergency medicine (EM) [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. The literature also shows that PSA is increasingly performed by other specialists such as cardiologists and gastroenterologists for short uncomfortable procedures outside the operating room and without the assistance of anesthesiologists [15][16][17].…”

Sedation for oocyte retrieval using target controlled infusion of propofol and incremental alfentanil delivered by non‐anaesthetists

“…Accident and emergency (A&Es) departments continue to draw inferences of 'safety' after describing sedation with propofol in limited numbers (without reference to 95% CI) and with little emphasis on maintaining verbal contact [16,17]. The Academy of Royal Colleges document on safe sedation practice, led by the Royal College of Anaesthetists but with members from all relevant specialties including the Faculty of Accident & Emergency Medicine, is very clear on this topic.…”

“…the protocol). It is disappointing that A&E departments administering propofol sedation can erroneously be called safe when the airway event rate is 80 ⁄ 1000 [17], almost 30-fold higher than those described in anaesthetists. It has been stated that safety for alternative or non-standard techniques of sedation should be demonstrated in hundreds of patients [18].…”