Is normal pregnancy atherogenic?

Martin, Una; Davies, Charli S; Hayavi, Sima; Hartland, Andrew; Dunne, Fidelma

doi:10.1042/cs0960421

Cited by 96 publications

(76 citation statements)

References 27 publications

(37 reference statements)

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“…Pregnancy is known to cause 100-fold increases in endogenous reproductive hormones, including progesterone and estrogens (estriol, estrone, and 17-β estradiol), 45 as well as production of human placental lactogen. 46 During gestation, TC and LDL-C levels increase by 40%-50%, TG levels increase by more than 2-fold, 47,48 and HDL-C increases by 0-25%. During the puerperium, TG returns rapidly to baseline, 49,50 whereas TC and LDL-C 49 have a slower decline throughout the first year postpartum.…”

Section: Discussionmentioning

confidence: 99%

Do Long-Term HDL-C Declines Associated with a First Birth Vary by apo E Phenotype? The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Gunderson

Whitmer

Lewis

et al. 2005

Journal of Women's Health

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Section: Discussionmentioning

confidence: 99%

Do Long-Term HDL-C Declines Associated with a First Birth Vary by apo E Phenotype? The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Gunderson

Whitmer

Lewis

et al. 2005

Journal of Women's Health

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“…Analytically, the average serum LDL-C concentration increases by about 0.80 mmol/L in the second trimester compared with the first trimester and 0.69 mmol/L in the third trimester compared with the second trimester (6). The major increase of the serum cholesterol concentration occurs in the second trimester (25-50%).…”

mentioning

confidence: 90%

“…These biochemical changes may be relevant for the long-term cardiovascular health of women, especially those of high parity who are at high risk for cardiovascular disease (e.g. women with diabetes) (6,11).…”

mentioning

confidence: 99%

Lipid Profile of Healthy Women During Normal Pregnancy

Διαρεμέ¹,

Καρκαλούσος²,

Theodoropoulos³

et al. 2009

Journal of Medical Biochemistry

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Lipid Profile of Healthy Women During Normal PregnancyThe four basic lipid indexes (Chol, Trig, HDL-C and LDL-C) increase during pregnancy, following different rates of increase. Among the four analytes triglycerides show the largest increase and HDL-C the smallest. All analyte values are raised during the 40 weeks of pregnancy, except HDL-C which is stabilized during the second trimester. After delivery the values decrease, except LDL-C which remains steady (for some weeks) before starting to fall following the others. In this study the relations between the four lipid indexes and some predisposing factors (age, gestational age, nationality, body mass index, profession, smoking and diabetes during pregnancy) were investigated. The sample consisted of 413 pregnant women, mainly Greeks and Albanians. After regression analysis it was proved that the only common predisposing factor was the gestational age. Triglycerides and total cholesterol are also influenced by the women's age. The lipid indexes showed no important difference between the pregnant women in the first trimester and the non-pregnant women. On the contrary, there was a statistical difference between the pregnant women in the second and third trimester and between them and the women in the first trimester. The percentages of increase between first and second trimester were: Chol: 38%, Trig: 115%, HDL-C: 30%, LDL-C: 33%. The percentages of increase between first and third trimester were: Chol: 65%, Trig: 208%, HDL-C: 26%, LDLC: 64%.

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“…Otros estudios, como los de Martin y cols (25), también informan que CT, TG y c-LDL aumentan en el embarazo, por lo que concluyen que durante la gestación normal se desarrolla un perfil lipídico aterogénico.…”

Section: Discussionunclassified

Perfil Lipídico Por Trimestre De Gestación en Una Población De Mujeres Adultas

Benítez

Bonneau

Rascón³

et al. 2010

Rev. chil. obstet. ginecol.

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RESUMENAntecedentes: En el embarazo se producen variaciones hormonales muy marcadas y estas se asocian con grandes modificaciones del perfil lipídico. Objetivos: Evaluar el perfil lipídico de mujeres adultas por trimestre de gestación y comparar el perfil lipídico de un grupo control de mujeres no embarazadas con gestantes del primer trimestre, que consultan al servicio de Maternidad del Hospital Público Provincial "Dr. Ramón Madariaga". Método: Se estudiaron 248 embarazadas, 69 en primer trimestre, 78 segundo y 101 tercero. Además un grupo control de 43 no gestantes con distribución etárea, índice de masa corporal y criterios de exclusión similares al grupo de gestantes. Se extrajo sangre con 12 horas de ayuno para las determinaciones bioquímicas, las cuales fueron realizadas por métodos enzimáticos colorimétricos, con controles de calidad interno y externo. Resultados: Se encontró que colesterol total, triglicéridos, col-VLDL, col-LDL, los índices colesterol total/col-HDL y triglicéridos/col-HDL, fueron aumentando significativamente en cada trimestre, mientras que el c-HDL no presentó diferencias. Los valores de percentilo 95 del tercer trimestre para CT de 321 mg/dl y TG 371 mg/dl, podrían ser utilizados como valores de corte en nuestra población. Cuando se comparó mujeres no gestantes versus embarazadas del primer trimestre no se encontraron cambios significativos. Conclusiones: El seguimiento del perfil lipídico de las gestantes podría convertirse en una herramienta diagnóstica que permita monitorear aumentos que superen lo considerado como fisiológico, llevando a un adecuado control prenatal. PALABRAS CLAVE: Riesgo aterogénico, embarazo, perfil lipídico SUMMARY Background:In pregnancy hormonal changes occur very marked and these are associated with major changes in the lipid profile. Aims: To evaluate the lipid profile of adult women during normal pregnancy in the first, second and third trimester and to compare the lipid profile of woman who are not pregnant with the lipid profile of woman who are in the first trimester of gestation and who are attended at the Maternity Public and Provincial Hospital "Dr. Ramón Madariaga". Methods: 248 pregnant women were evaluated of which: 69 women were in the first trimester; 78 women were in the second trimester and 101 women were in the third trimester. In addition a control group of 43 non-pregnant women with age distribution, body mass index and exclusion criteria similar to the group of pregnant women. Blood was extracted after twelve hours fasting to get the biochemical determinations which results were gotten by enzymatic colorimetric methods, with internal and external quality control. Results: It was found that total cholesterol; triglycerides, very low density and low density lipoprotein, the total cholesterol index/ high density lipoprotein y triglycerides/ high

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Is normal pregnancy atherogenic?

Cited by 96 publications

References 27 publications

Do Long-Term HDL-C Declines Associated with a First Birth Vary by apo E Phenotype? The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Do Long-Term HDL-C Declines Associated with a First Birth Vary by apo E Phenotype? The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Lipid Profile of Healthy Women During Normal Pregnancy

Perfil Lipídico Por Trimestre De Gestación en Una Población De Mujeres Adultas

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