Is muscle hypertrophy following resistance exercise regulated by truncated splice variants of PGC-1<i>α</i>?

Perry, Christopher G. R.

doi:10.1111/apha.12348

Cited by 3 publications

(2 citation statements)

References 16 publications

(24 reference statements)

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“…Previous studies have indicated that PGC-1α, G6Pase, SHP and PEPCK may be involved in the beneficial effects of FXR agonist in different animal models (33,34). PGC-1α may be one of the most critical metabolic switches in diabetes (35), obesity (36) and exercise-inducing effects (37,38). Wang et al (39) reported that the orphan nuclear receptor, SHP, represses the promoter activity of PGC-1α.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effect of farnesoid X receptor activation on metabolism in a diabetic rat model

Zhang

Wang

Zhao-hong

et al. 2016

Molecular Medicine Reports

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Farnesoid X receptor (FXR) is an important regulator of glucose and lipid homeostasis. However, the exact role of FXR in diabetes remains to be fully elucidated. The present study examined the effects of chenodeoxycholic acid (CDCA), an agonist of FXR, on metabolism profile in a rat model of type 2 diabetes mellitus (T2DM). Male Wistar rats (8‑week‑old; n=40) were randomized into the following four groups (n=10): Untreated control, CDCA‑treated, T2DM, and CDCA‑treated T2DM. To establish the T2DM model, the rats were fed a high‑fat diet (HFD) for 4 weeks and received a single low‑dose intraperitoneal injection of streptozotocin (30 mg/kg), followed by an additional 4 weeks of HFD feeding. CDCA was administrated (10 mg/kg/d) intraperitoneally for 10 days. Reverse transcription‑quantitative polymerase chain reaction and western blotting assays were performed to determine the RNA and protein expression of FXR, phosphoenolpyruvate carboxykinase, G6Pase, proliferator‑activated receptor‑γ coactivator‑1 and short heterodimer partner in rat liver tissue. The results revealed that FXR activation by CDCA did not reduce body weight, but it lowered the plasma levels of fasting glucose, insulin and triglycerides in the T2DM rats. CDCA administration reversed the downregulation of the mRNA and protein expression of FXR in the T2DM rat liver tissue samples. Furthermore, treatment with CDCA reduced the mRNA and protein expression levels of phosphoenolpyruvate carboxykinase, glucose 6‑phosphatase and peroxisome proliferator‑activated receptor‑γ coactivator‑1 in the liver tissue samples of the T2DM rats. By contrast, CDCA treatment increased the mRNA and protein expression levels of short heterodimer partner in the liver tissue samples of the T2DM rats. In conclusion, FXR agonist treatment induces beneficial effects on metabolism in the rat T2DM model. In conclusion, the present study indicated that the FXR agonist may be useful for the treatment of T2DM and hypertriglyceridemia.

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Section: Discussionmentioning

confidence: 99%

Beneficial effect of farnesoid X receptor activation on metabolism in a diabetic rat model

Zhang

Wang

Zhao-hong

et al. 2016

Molecular Medicine Reports

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“…One benefit of research reliant on the detection of RNA molecules is that with a little care 47 , you can be sure of the identity of the molecule you are quantifying (a situation far removed from antibody-based technologies; see below). However, in the case of lncRNAs, the situation is not nearly as simple as one might hope.…”

Section: Non-coding Rna That Has Potential To Impact On the Biology Omentioning

confidence: 99%

Molecular studies of exercise, skeletal muscle, and ageing

Timmons

Gallagher

2016

F1000Res

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The purpose of an F1000 review is to reflect on the bigger picture, exploring controversies and new concepts as well as providing opinion as to what is limiting progress in a particular field. We reviewed about 200 titles published in 2015 that included reference to ‘skeletal muscle, exercise, and ageing’ with the aim of identifying key articles that help progress our understanding or research capacity while identifying methodological issues which represent, in our opinion, major barriers to progress. Loss of neuromuscular function with chronological age impacts on both health and quality of life. We prioritised articles that studied human skeletal muscle within the context of age or exercise and identified new molecular observations that may explain how muscle responds to exercise or age. An important aspect of this short review is perspective: providing a view on the likely ‘size effect’ of a potential mechanism on physiological capacity or ageing.

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Influence of genetics and epigenetics on the process of muscle hypertrophy: a systematic review

Fajardo Colorado,

Correa Jaramillo,

González Arango

2023

Mov Sport Sci/Sci Mot

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Muscle hypertrophy is the increase in the size of the transverse diameter of muscle fibers. Although the mechanisms and signaling pathways that regulate hypertrophy are known, it is still unclear how much genetics and epigenetics contribute to this process; whether both mechanisms participate jointly, or whether there is a more significant influence of one event than the other. Therefore, this study aimed to extensively review the literature and determine the role of genes and epigenetic mechanisms in regulating muscle hypertrophy associated with physical activity and sport. For this purpose, the Scopus and ScienceDirect databases were reviewed, and the PubMed and Google Scholar search engines were used, where 25 articles met the inclusion criteria. Results demonstrated that there are several regulatory genes of muscle hypertrophy, such as MSTN, PGC-1 α, STARS, and JunB, among others, as well as genetic polymorphisms and vital participation of DNA methylation, which together would control signaling pathways and gene networks necessary for the development of this process.

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Is muscle hypertrophy following resistance exercise regulated by truncated splice variants of PGC-1α?

Cited by 3 publications

References 16 publications

Beneficial effect of farnesoid X receptor activation on metabolism in a diabetic rat model

Beneficial effect of farnesoid X receptor activation on metabolism in a diabetic rat model

Molecular studies of exercise, skeletal muscle, and ageing

Influence of genetics and epigenetics on the process of muscle hypertrophy: a systematic review

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