Is lymphovascular invasion a powerful predictor for biochemical recurrence in pT3 N0 prostate cancer? Results from the K-CaP database

Abstract

To assess the impact of lymphovascular invasion (LVI) on the risk of biochemical recurrence (BCR) in pT3 N0 prostate cancer, clinical data were extracted from 1,622 patients with pT3 N0 prostate cancer from the K-CaP database. Patients with neoadjuvant androgen deprivation therapy (n = 325) or insufficient pathologic or follow-up data (n = 87) were excluded. The primary endpoint was the oncologic importance of LVI, and the secondary endpoint was the hierarchical relationships for estimating BCR between the evaluated variables. LVI was noted in 260 patients (21.5%) and was significantly associated with other adverse clinicopathologic features. In the multivariate Cox regression analysis, LVI was significantly associated with an increased risk of BCR after adjusting for known prognostic factors. In the Bayesian belief network analysis, LVI and pathologic Gleason score were found to be first-degree associates of BCR, whereas prostate-specific antigen (PSA) level, seminal vesicle invasion, perineural invasion, and high-grade prostatic intraepithelial neoplasia were considered second-degree associates. In the random survival forest, pathologic Gleason score, LVI, and PSA level were three most important variables in determining BCR of patients with pT3 N0 prostate cancer. In conclusion, LVI is one of the most powerful adverse prognostic factors for BCR in patients with pT3 N0 prostate cancer.

Impact of GAS5 genetic polymorphism on prostate cancer susceptibility and clinicopathologic characteristics

“…There was also a better trend of decreasing lymphovascular invasion (OR=0.647; 95% CI=0.435-1.044, p=0.076). Lymphovascular invasion, also known as minimal lymphatic involvement, has been frequently reported as a prognostic factor to predict biochemical recurrence (BCR) after radiotherapy and radical prostatectomy [36][37][38][39]. In the cause analysis of BCR, the increasing risk was mainly from progression to lymph node metastasis instead of residual tumor cells of positive surgical margins [39].…”

A Study on the Interfacial Structure Design of Self‐Compliance Ni/HfOx/Ni Bipolar Selectors and Trap‐to‐Trap Tunneling Mechanism Caused by Redox Reaction

“…The high endurance voltage reached AE10 V, which is the highest ever proposed. [12][13][14]16,17,26] It is significant that the proposed selector has a self-protection property and provides a guarantee of the low power consumption of the device and the system. Moreover, there were two-step upward current jumps at 1.0 V (first set) and 1.6 V (second set) and two-step downward jumps at 1.0 V (first reset) and 0.7 V (second reset).…”

“…[12][13][14][15] Little research on selectors with self-compliance characteristics has been proposed before, although RRAM with self-compliance characteristics has been reported by many research groups. For example, Ni/CuO x /Ni nanowire RRAM with self-compliance characteristics was synthesized by electrochemical deposition [16] and can retain its current without electrical breakdown with a high applied voltage up to 8 V. It is the spatial restriction of the current path in nanowires that causes RRAM to exhibit selfcompliance behavior, which indicates that structural construction is crucial to form self-compliance characteristics. Compared with RRAM with self-compliance characteristics, selectors with self-compliance characteristics can be used in series of high-performance RRAMs and suppress the sneak current by themselves.…”

Pathological and oncological features of Korean prostate cancer patients eligible for active surveillance: analysis from the K-CaP registry

“…The K-CaP registry is an online, observational and automated data-entry system, consisting of 6415 patients who underwent RP between May 2001 and April 2013 at five high-volume institutions in Korea: Asan Medical Center, Samsung Medical Center, Seoul National University Bundang Hospital, Seoul St. Mary's Hospital and Yonsei University Severance Hospital. Details of the database have been previously reported (8). For all patients, the decision for RP was made based on the physician's discretion and the patient's preference.…”