2019
DOI: 10.7150/ijms.38080
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Abstract: Down-regulation of Growth arrest-specific 5 (GAS5) is correlated with enhanced cell proliferation and poorer prognosis of prostate cancer. We aimed to investigate the effect of variant rs145204276 of GAS5 on the prostate cancer susceptibility and clinicopathologic characteristics. In this study, 579 prostate cancer patients who underwent robot-assisted radical prostatectomy and 579 healthy controls were included. The frequency of the allele del of rs145204276 were compared between the patients and the controls… Show more

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Cited by 23 publications
(30 citation statements)
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References 45 publications
(57 reference statements)
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“…Two GAS5 genetic variants rs145204276 and rs55829688 were detected in compliance with the data of International HapMap Project and previous study [28]. The polymorphism rs145204276 AGGCA/-was demonstrated to be located at the promoter region of lncRNA GAS5 and was associated with the progression of several cancers [28,29]. GAS5 genetic polymorphisms rs145204276 and rs55829688 were examined by ABI StepOne Real-Time PCR System (Applied Biosystems, Foster City, CA, USA) as well as delineated with SDS vers.…”
Section: Selection Of Gas5 Genetic Polymorphismsmentioning
confidence: 80%
“…Two GAS5 genetic variants rs145204276 and rs55829688 were detected in compliance with the data of International HapMap Project and previous study [28]. The polymorphism rs145204276 AGGCA/-was demonstrated to be located at the promoter region of lncRNA GAS5 and was associated with the progression of several cancers [28,29]. GAS5 genetic polymorphisms rs145204276 and rs55829688 were examined by ABI StepOne Real-Time PCR System (Applied Biosystems, Foster City, CA, USA) as well as delineated with SDS vers.…”
Section: Selection Of Gas5 Genetic Polymorphismsmentioning
confidence: 80%
“…CE19062A). Medical information including age at diagnosis, initial prostate specific antigen (PSA) level at diagnosis, pathologic Gleason grade group, clinical and pathological TNM staging, seminal vesicle invasion, perineural invasion, lymphovascular invasion, and D’Amico classification were acquired from each patient’s medical records [ 34 , 35 , 36 , 37 ]. In this study, the Gleason grade group and D’Amico classification were grouped according to the International Society of Urological Pathology (ISUP) consensus in 2016 [ 38 ].…”
Section: Methodsmentioning
confidence: 99%
“…[130][131][132] In terms of its mechanism of action, GAS5 may act as a sponge for miR-103, which in turn, inactivates the AKT/mTOR signaling pathway, thus inhibiting prostate cancer cell proliferation. 131 In addition, two single nucleotide polymorphisms (SNPs) located in the chromosomal segment of GAS5 (rs55829688 and rs145204276) can increase GAS5 expression, [133][134][135] and are associated with improved survival in prostate cancer. 133 Patients with prostate cancer and the GAS5 rs145204276 polymorphism are associated with a low risk of pathologic N stage and seminal vesicle invasion.…”
Section: Prostate Cancermentioning
confidence: 99%
“…133 Patients with prostate cancer and the GAS5 rs145204276 polymorphism are associated with a low risk of pathologic N stage and seminal vesicle invasion. 135 Furthermore, patients with prostate cancer aged >65 years who carry the GAS5 rs145204276 polymorphism show decreased risk of clinical T stage, pathologic N stage, and lymphovascular invasion. 135 Differential expression of GAS5 due to these SNPs likely affects the miR-21/programmed cell death 4 (PDCD4)/PTEN axis, 133 as well as the miR-1284/AKT 133 and miR-1284/high mobility group box 1 (HMGB1) 134 pathways.…”
Section: Prostate Cancermentioning
confidence: 99%
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