Is leptin receptor gene (Gln223Arg) polymorphism associated with disease susceptibility and severity in patients of primary knee osteoarthritis?

Fadda, Samia H.; Abdelaleem, Enas A.; Mohamed, Rabab A; Mansour, Hanaa M.H.; Doudar, Noha A

doi:10.1016/j.ejr.2019.04.006

Cited by 6 publications

(8 citation statements)

References 35 publications

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“…Two studies targeting at the Chinese population indicated an association between LEPR SNP and the susceptibility to knee OA; hence, it was speculated that there might be a genetic marker predicting the risk of this disease [ 27 , 28 ]. On the contrary, Doudar et al reported neither direct genetic association between rs1137101 SNP and the susceptibility of primary knee OA nor any gender difference in the frequency distribution of alleles or genotypes in Egyptians [ 30 ]. In the present meta-analysis, rs1137101 within the LEPR gene was found to be associated with a reduced risk of knee OA in the overall population and the Asian subgroup.…”

Section: Discussionmentioning

confidence: 99%

Associations between adipokines gene polymorphisms and knee osteoarthritis: a meta-analysis

Wang

Meng

et al. 2022

BMC Musculoskelet Disord

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Background Adipokines gene polymorphisms are speculated to be associated with the risk of knee osteoarthritis (OA), but evidence remains conflicting. This study therefore aimed to examine whether associations exist between adipokines gene polymorphisms and knee OA by considering the evidence collected from eligible studies through a meta-analysis. Methods A systematic search was performed on PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang up to March 31, 2020. Meta-analysis was carried out by focusing on the associations between adipokines gene polymorphisms and knee OA with the allele model, dominant model, and recessive model. Results The present meta-analysis included 5 eligible studies for ADIPOQ rs1501299 with 1,021 cases and 1,097 controls, 3 eligible studies for ADIPOQ rs2241766 with 549 cases and 544 controls, 3 eligible studies for LEPR rs1137101 with 808 cases and 856 controls, 2 eligible studies for VISFATIN rs4730153 with 339 cases and 680 controls and 2 eligible studies for VISFATIN rs16872158 with 339 cases and 680 controls. Significant association was observed between LEPR rs1137101 and knee OA in the overall population (recessive: OR = 0.40, 95% CI 0.21–0.79). Limited data revealed that associations may exist between ADIPOQ rs2241766 and knee OA in Asians (dominant: OR = 1.35, 95% CI 1.03–1.78), between VISFATIN rs4730153 and knee OA in Asians (allele: OR = 0.58, 95% CI 0.41–0.83; dominant: OR = 0.57, 95% CI 0.39–0.83), and between VISFATIN rs16872158 and knee OA in Asians (allele: OR = 1.84, 95% CI 1.26–2.68; dominant: OR = 1.94, 95% CI 1.31–2.89). Conclusions Adipokines gene polymorphisms may be associated with knee OA. The association was observed in LEPR rs1137101 in the present study. In addition, limited data revealed that associations may also exist in ADIPOQ rs2241766, VISFATIN rs4730153 and VISFATIN rs16872158. Prospero registration CRD42020187664.

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Section: Discussionmentioning

confidence: 99%

Associations between adipokines gene polymorphisms and knee osteoarthritis: a meta-analysis

Wang

Meng

et al. 2022

BMC Musculoskelet Disord

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“…There are two studies targeting at the Chinese population indicating that LEPR SNP was associated with the susceptibility to knee OA; hence, it was speculated that there might be a genetic marker predicting the risk of this disease [28,29]. On the contrary, Doudar et al reported neither direct genetic association between rs1137101 SNP and the susceptibility of primary knee OA nor any gender difference in the frequency distribution of alleles or genotypes in Egyptians [31]. In the present study, rs1137101 within the LEPR gene was found to be associated with a reduced risk of OA in the overall population and the Asian subgroup.…”

Section: Discussionmentioning

confidence: 99%

“…1 shows a flow chart that illustrates the selection process. A total of 13 publications (7 on ADIPOQ polymorphism, 4 on LEPR polymorphism, 2 on LEP polymorphism, 2 on RESISTIN polymorphism, and 1 on VISFATIN polymorphism) containing 3,661 OA patients and 4,864 controls were included [21][22][23][24][25][26][27][28][29][30][31][32][33]. Table 1 details the characteristics of the included studies.…”

Section: Eligible Studiesmentioning

confidence: 99%

“…This milestone study initiated the journey to examine adipokines as a metabolic link between obesity and OA. Several SNPs of the adipokines genes have been associated with OA [21][22][23][24][25][26][27][28][29][30][31][32][33], however, the results are inconsistent. For instance, a study from Thailand rejected any significant association between the ADIPOQ gene rs1501299 polymorphism and knee OA [24], while Jin et al reported that rs1501299 polymorphism intensified the risk of knee OA in Chinese subjects [21].…”

Section: Introductionmentioning

confidence: 99%

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Associations Between Adipokines Gene Polymorphisms and Osteoarthritis: a Meta-analysis

Wang

Meng

et al. 2021

Preprint

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Background: Adipokines gene polymorphisms are speculated to have associations with the risk of osteoarthritis (OA), but evidences remain conflicting. This study therefore aimed to examine the potential associations between adipokines gene polymorphisms and OA.Methods: A systematic search was performed on PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang up to March 31, 2020. Meta-analysis was carried out by focusing on associations between adipokines gene polymorphisms and OA with allele model, dominant model, recessive model, homozygote model, and heterozygote model.Results: The present meta-analysis included 13 studies containing 3,661 OA patients and 4,864 controls for analysis. Significant associations were observed between ADIPOQ rs2241766 and OA in Asians (dominant: OR = 1.35, 95% CI 1.03-1.78; heterozygote: OR = 1.43, 95% CI 1.07-1.19), between LEPR rs1137101 and OA in the overall population (recessive: OR = 0.40, 95% CI 0.21-0.79; homozygote: OR = 0.38, 95% CI 0.18-0.79), between VISFATIN rs4730153 and OA in Asians (allele: OR = 0.58, 95% CI 0.41-0.83; dominant: OR = 0.57, 95% CI 0.39-0.83; heterozygote: OR = 0.59, 95% CI 0.40-0.86), and between VISFATIN rs16872158 and OA in Asians (allele: OR = 1.84, 95% CI 1.26-2.68; dominant: OR = 1.94, 95% CI 1.31-2.89; heterozygote: OR = 1.97, 95% CI 1.31-2.95).Conclusions: Adipokines gene polymorphisms may be associated with OA. In particular, associations were observed in ADIPOQ rs2241766, LEPR rs1137101, VISFATIN rs4730153, and VISFATIN rs16872158 in the present study. PROSPERO registration number: CRD42020187664.

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“…The molecular genetic investigations have gained an increasingly significant role in elaborating the evidence for the genetic component of OA through searching for OA susceptibility loci. Recently, many studies have been conducted to investigate the relationship between gene polymorphism and primary OA in Egypt including matrilin 3, growth differentiation factor 5, leptin receptor, and tumor necrosis factor α genes [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Association between primary osteoarthritis and ADAMTS14 single nucleotide polymorphism in Egyptian population: a case-control study

Mostafa

Ibrahim

Mikhael

et al. 2022

Egypt Rheumatol Rehabil

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Background Primary osteoarthritis is considered one of the most common and the most studied musculoskeletal disorder. Nevertheless, the risk factors remain unclear. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 14 (ADAMTS14) gene is involved in the cleavage of amino-terminal propeptides from type II procollagen, a necessary step in the formation of collagen fibers. The abnormal metabolism of collagen fibers type II leads to a decreased mechanical strength of joint cartilage which is one of the most important contributing factors to joint osteoarthritis. We aimed at investigating the association between primary osteoarthritis and ADAMTS14 gene rs4747096 single nucleotide polymorphism in a sample of Egyptian patients and analyzing the relationship between this genetic polymorphism with the severity of osteoarthritis. Sixty-five Egyptian patients who fulfilled the American College of Rheumatology criteria for primary knee osteoarthritis were compared with thirty-one apparently healthy subjects. Genotyping was performed by TaqMan single nucleotide polymorphism genotyping assay. Results There was a statistically significantly higher frequency of AA genotype among osteoarthritis patients compared to the control group (P = 0.004). The number of affected hand joints was significantly higher among patients with ADAMTS14 AA genotype in comparison to patients with ADAMTS14 AG genotype (P = 0.002). In addition, AA genotype was associated with statistically significantly higher Kellgren-Lawrence radiological grades in the knee and hand joints (proximal interphalangeal and thumb interphalangeal joints) (P = 0.037, 0.003, and 0.030 respectively). Conclusion The study showed an association between the AA genotype of ADAMTS14 gene rs4747096 single nucleotide polymorphism with knee and hand osteoarthritis and osteoarthritis severity in these joints. The AA genotype of ADAMTS14 gene rs4747096 single nucleotide polymorphism could be implicated in the increased incidence of primary osteoarthritis development and elevated disease severity among the Egyptian population.

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Is leptin receptor gene (Gln223Arg) polymorphism associated with disease susceptibility and severity in patients of primary knee osteoarthritis?

Cited by 6 publications

References 35 publications

Associations between adipokines gene polymorphisms and knee osteoarthritis: a meta-analysis

Associations between adipokines gene polymorphisms and knee osteoarthritis: a meta-analysis

Associations Between Adipokines Gene Polymorphisms and Osteoarthritis: a Meta-analysis

Association between primary osteoarthritis and ADAMTS14 single nucleotide polymorphism in Egyptian population: a case-control study

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