Associations between adipokines gene polymorphisms and knee osteoarthritis: a meta-analysis

Abstract

Background Adipokines gene polymorphisms are speculated to be associated with the risk of knee osteoarthritis (OA), but evidence remains conflicting. This study therefore aimed to examine whether associations exist between adipokines gene polymorphisms and knee OA by considering the evidence collected from eligible studies through a meta-analysis. Methods A systematic search was performed on PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang up to March 31, 2020. Meta-analysis was carried out by focusing on the associations between adipokines gene polymorphisms and knee OA with the allele model, dominant model, and recessive model. Results The present meta-analysis included 5 eligible studies for ADIPOQ rs1501299 with 1,021 cases and 1,097 controls, 3 eligible studies for ADIPOQ rs2241766 with 549 cases and 544 controls, 3 eligible studies for LEPR rs1137101 with 808 cases and 856 controls, 2 eligible studies for VISFATIN rs4730153 with 339 cases and 680 controls and 2 eligible studies for VISFATIN rs16872158 with 339 cases and 680 controls. Significant association was observed between LEPR rs1137101 and knee OA in the overall population (recessive: OR = 0.40, 95% CI 0.21–0.79). Limited data revealed that associations may exist between ADIPOQ rs2241766 and knee OA in Asians (dominant: OR = 1.35, 95% CI 1.03–1.78), between VISFATIN rs4730153 and knee OA in Asians (allele: OR = 0.58, 95% CI 0.41–0.83; dominant: OR = 0.57, 95% CI 0.39–0.83), and between VISFATIN rs16872158 and knee OA in Asians (allele: OR = 1.84, 95% CI 1.26–2.68; dominant: OR = 1.94, 95% CI 1.31–2.89). Conclusions Adipokines gene polymorphisms may be associated with knee OA. The association was observed in LEPR rs1137101 in the present study. In addition, limited data revealed that associations may also exist in ADIPOQ rs2241766, VISFATIN rs4730153 and VISFATIN rs16872158. Prospero registration CRD42020187664.

Diagnosis and Treatment of Knee Osteoarthritis: Modern Aspects

“…The association was observed in gene LEPR 1,137,101. Additionally, limited data revealed that associations may also exist in ADIPOQ rs2241766, VISFATIN rs4730153 and VISFATIN rs16872158 [23]. The relationship between obesity and the prevalence of KOA has been confirmed by a number of studies, in which it was indicated that obesity contributes to an increase in the load on the joint, the development of an inflammatory response, negative consequences in the body and lifestyle change in favor of reducing physical activity [16].…”

The rs1477196 SNP of the FTO Gene is Associated with Primary Knee Osteoarthritis in a Female Population from Northern Mexico

“…In adult and pediatric Latin populations, particularly among Mexican people, the highest frequencies of obesity worldwide have been observed 8 . Obesity is a risk factor for OA not only through the action of mechanical forces that overload the joints but also due to a variety of metabolically active adipokines that play a role as mediators of inflammation 9,10 .…”

Disease-modifying agents in osteoarthritis: where are we now and what does the future hold?

“…The association between OA and metabolic syndrome is now well established, but also emerging is the shared genetic basis between OA and conditions such as obesity and major depressive disorder. 30 , 31 , 34 Furthermore, our knowledge of the interplay between the gut microbiome, the environment, and OA is rapidly evolving. The collection of trillions of microbial organisms that reside in the gastrointestinal tract has been shown to play a key role in host metabolism, the immune system, and inflammatory response.…”