ironPhone: Mobile device-coupled point-of-care diagnostics for assessment of iron status by quantification of serum ferritin

Srinivasan, Balaji; O'Dell, Dakota; Finkelstein, Julia L.; Lee, Seoho; Erickson, David; Mehta, Saurabh

doi:10.1016/j.bios.2017.07.038

Cited by 56 publications

(36 citation statements)

References 28 publications

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“…Interestingly, free Internet services like Internet.org (a Facebook‐led initiative) can even be accessed in many African and other countries (in Asia and Latin America) without a data plan which may further drive Internet‐enabled diagnostics. For example, among others, the imaging capabilities of smartphones have been exploited for the analysis of semen, iron concentration in blood or even amplification and fluorescent detection of genetic materials from viruses using disposable sampling and sensing elements. The detection capabilities of smartphones can also be extended beyond just imaging.…”

Section: Fields Of Applicationmentioning

confidence: 99%

Disposable Sensors in Diagnostics, Food, and Environmental Monitoring

et al. 2019

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Disposable sensors are low‐cost and easy‐to‐use sensing devices intended for short‐term or rapid single‐point measurements. The growing demand for fast, accessible, and reliable information in a vastly connected world makes disposable sensors increasingly important. The areas of application for such devices are numerous, ranging from pharmaceutical, agricultural, environmental, forensic, and food sciences to wearables and clinical diagnostics, especially in resource‐limited settings. The capabilities of disposable sensors can extend beyond measuring traditional physical quantities (for example, temperature or pressure); they can provide critical chemical and biological information (chemo‐ and biosensors) that can be digitized and made available to users and centralized/decentralized facilities for data storage, remotely. These features could pave the way for new classes of low‐cost systems for health, food, and environmental monitoring that can democratize sensing across the globe. Here, a brief insight into the materials and basics of sensors (methods of transduction, molecular recognition, and amplification) is provided followed by a comprehensive and critical overview of the disposable sensors currently used for medical diagnostics, food, and environmental analysis. Finally, views on how the field of disposable sensing devices will continue its evolution are discussed, including the future trends, challenges, and opportunities.

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Section: Fields Of Applicationmentioning

confidence: 99%

Disposable Sensors in Diagnostics, Food, and Environmental Monitoring

et al. 2019

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“…Opportunities for future research include understanding the values and preferences of parents and practitioners for screening for iron deficiency; conducting a budget impact analysis to assess system-level costs associated with screening; developing a risk-stratification tool to be used for targeted screening (similar to tools for assessing risk of diabetes in adults); 55 and validating a point-of-care tool for serum ferritin to improve convenience and reduce cost. 16,56…”

Section: Open Researchmentioning

confidence: 99%

Iron deficiency screening for children at 18 months: a cost-utility analysis

Carsley¹,

Fu²,

Borkhoff³

et al. 2019

cmajo

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Background: The peak prevalence of iron deficiency is in children 6 months to 3 years of age, a sensitive period for neuro development. Our study objective was to examine the costutility of a proposed iron deficiency screening program for 18monthold children. Methods: We used a decision tree model to estimate the costs in 2019 Canadian dollars and qualityadjusted life years (QALYs) associated with 3 iron deficiency screening strategies: no screening, universal screening and targeted screening for a highrisk popu lation. We used a societal perspective and assessed lifetime QALY gains. We derived outcomes from the literature and prospectively collected data. We performed oneway and probabilistic sensitivity analyses to assess parameter uncertainty.

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“…Portable devices can also be used to determine food deficiency. For instance, ironPhone was coupled to point‐of‐care testing for assessment of iron status, an urgent public health problem related to maternal and child health . The device assessed the iron status based on serum ferritin levels.…”

Section: Applications In Field Research and Diagnosticsmentioning

confidence: 99%

Portable Multiplex Optical Assays

Coşkun

Topkaya

Yetisen

et al. 2018

Advanced Optical Materials

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performed at home and results can be integrated by online interfaces. [5] The test results and diagnostic information can be analyzed by the medical professionals from remote locations, improving the connectivity of central hubs to the public venues.Numerous scientific discoveries have been made in advanced settings and wellequipped laboratories. The necessity and complexity of these environments limit access to research equipment worldwide. Thus, decentralization of research laboratories has become an alternative solution to improve access to experimentation in field conditions. For instance, a paper origami microscope [6] that fit into a palm of a student made a powerful investigation tool for environment and materials. A detailed analysis of sound recordings by smartphones enabled identification of distinct mosquitoes. [7] These fielddeployable devices and platforms have stimulated emergence of citizen scientists, a population that collectively performs scientific inquiries in public settings.Rich biomolecular measurements from field-portable devices improve the quality of results in terms of accuracy and depth. Monitoring multiple blood markers has enabled diagnostic precision and thorough scientific investigation of blood constituent in patients. Therefore, field-deployable devices should ideally have multiplexed detection of target specimens. Design of such multiplexed detection technologies requires decent complexity at low cost for wide-scale adoptability.In this article, we provide an overview of field-compatible devices with high parameter analysis capabilities for both health monitoring purposes and scientifically enlightening Global health issues are increasingly becoming critical with high fatality rate due to chronic and infectious diseases. Emerging technologies aim to address these problems by understanding the causes of lethal conditions and diagnosing symptoms at early stage. Existing commercial diagnostics primarily focus on single-plex assays due to ease-of-use, simplicity in analysis, and amenability to mass manufacturing. Many research grade devices have utilized only a few molecular and morphological signatures in bodily fluids. However, multiplex devices can improve accuracy, sensitivity, and scalability of research and diagnostic devices. This review presents multiplex assays that utilize optical, electrical, and chemical methods and materials that have the potential to improve portable point-of-care diagnostics. The critical role of emerging optical and complementary assays with multiple contrast mechanisms is investigated to enable highly multiplex analysis in field settings. Multiparameter portable devices for field applications toward health monitoring, food testing, air quality monitoring, and microanalysis in other extreme conditions are examined. Current trends indicate the need for validation of health diagnosis based on a large number of biomarkers in randomized clinical trials. Advanced digital analysis, crowdsourced solutions, and robust user interfaces will become an integral ...

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ironPhone: Mobile device-coupled point-of-care diagnostics for assessment of iron status by quantification of serum ferritin

Cited by 56 publications

References 28 publications

Disposable Sensors in Diagnostics, Food, and Environmental Monitoring

Disposable Sensors in Diagnostics, Food, and Environmental Monitoring

Iron deficiency screening for children at 18 months: a cost-utility analysis

Portable Multiplex Optical Assays

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