Iron: Mammalian defense systems, mechanisms of disease, and chelation therapy approaches

Kontoghiorghes, George J.; Weinberg, Eugene D.

doi:10.1016/0268-960x(95)90038-1

Cited by 127 publications

(76 citation statements)

References 113 publications

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“…One (AAEL015458/15639/Supp_Aedes05593) is a predicted transferrin that is up-regulated in response to bacterial infection (Yoshiga et al, 1997). Transferrin is an iron-binding protein and may fight pathogens by depriving them of iron, as has been proposed for vertebrate lactoferrin (Kontoghiorghes and Weinberg, 1995). In the ovaries of female Ae.…”

Section: 5e Defense Response and Toxicity-mentioning

confidence: 99%

Identity and transfer of male reproductive gland proteins of the dengue vector mosquito, Aedes aegypti: Potential tools for control of female feeding and reproduction

Sirot

Poulson

McKenna

et al. 2008

Insect Biochemistry and Molecular Biology

149

166

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Male reproductive gland proteins (mRGPs) impact the physiology and/or behavior of mated females in a broad range of organisms. We sought to identify mRGPs of the yellow fever mosquito, Aedes aegypti, the primary vector of dengue and yellow fever viruses. Earlier studies with Ae. aegypti demonstrated that "matrone" (a partially purified male reproductive accessory gland substance) or male accessory gland fluid injected into virgin female Ae. aegypti affect female sexual refractoriness, blood feeding and digestion, flight, ovarian development, and oviposition. Using bioinformatic comparisons to Drosophila melanogaster accessory gland proteins and mass spectrometry of proteins from Ae. aegypti male accessory glands and ejaculatory ducts (AG/ED) and female reproductive tracts, we identified 63 new putative Ae. aegypti mRGPs. Twenty-one of these proteins were found in the reproductive tract of mated females, but not of virgin females, suggesting that they are transferred from males to females during mating. Most of the putative mRGPs fall into the same protein classes as mRGPs in other organisms, although some appear to be evolving rapidly and lack identifiable homologs in Culex pipiens, Anopheles gambiae, and D. melanogaster. Our results identify candidate male-derived molecules that may have an important influence on behavior, survival and reproduction of female mosquitoes.

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Section: 5e Defense Response and Toxicity-mentioning

confidence: 99%

Identity and transfer of male reproductive gland proteins of the dengue vector mosquito, Aedes aegypti: Potential tools for control of female feeding and reproduction

Sirot

Poulson

McKenna

et al. 2008

Insect Biochemistry and Molecular Biology

149

166

View full text Add to dashboard Cite

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“…Cytokines may function by causing macrophages to actively limit their intracellular iron concentration in an attempt to restrict bacterial growth (172,312). Activated macrophages downregulate transferrin receptors, reducing iron levels (32).…”

Section: Role Of Iron Uptake In M Paratuberculosis Infectionsmentioning

confidence: 99%

Mycobacterium aviumsubsp.paratuberculosisin Veterinary Medicine

2001

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Mycobacterium avium subsp. paratuberculosis (basonym M. paratuberculosis) is the etiologic agent of a severe gastroenteritis in ruminants known as Johne's disease. Economic losses to the cattle industry in the United States are staggering, reaching $1.5 billion annually. A potential pathogenic role in humans in the etiology of Crohn's disease is under investigation. In this article, we review the epidemiology, pathogenesis, diagnostics, and disease control measures of this important veterinary pathogen. We emphasize molecular genetic aspects including the description of markers used for strain identification, diagnostics, and phylogenetic analysis. Recent important advances in the development of animal models and genetic systems to study M. paratuberculosis virulence determinants are also discussed. We conclude with proposals for the applications of these models and recombinant technology to the development of diagnostic, control, and therapeutic measures

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“…Recognition of the possible pathogenetic role of hyperferremia in patients receiving high-dose chemotherapy has led to the evaluation of the potential therapeutic value of iron chelation therapy in these patients [15,16]. Considering the potential value of iron chelation therapy in the prevention of septic infections caused by S. epidermidis, it is important to know whether bacteria at densities occurring in septicemia can utilise transferrin-bound iron for growth.…”

Section: Introductionmentioning

confidence: 99%

Dependence of Staphylococcus epidermidis on non-transferrin-bound iron for growth

Matinaho

2001

FEMS Microbiology Letters

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The ability of Staphylococcus epidermidis strains to grow in the presence of human transferrin and varying amounts of ferric iron was studied. At initial bacterial densities up to 10 4 cfu ml 31 , none of the three strains grew when transferrin iron saturation was below the full saturation point, whereas the bacteria grew consistently when transferrin was fully iron-saturated and there was non-transferrin-bound iron in the medium. Precultivation of the bacteria under iron-restricted conditions to induce siderophore production did not abolish the growth dependence on non-transferrin-bound iron. At initial bacterial densities of 10 6 cfu ml 31 , the bacteria proliferated consistently also in the presence of partially saturated transferrin. The results indicate that at low bacterial densities, S. epidermidis cannot utilise transferrin-bound iron for growth and that its proliferation is dependent on non-transferrin-bound iron. ß

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Iron: Mammalian defense systems, mechanisms of disease, and chelation therapy approaches

Cited by 127 publications

References 113 publications

Identity and transfer of male reproductive gland proteins of the dengue vector mosquito, Aedes aegypti: Potential tools for control of female feeding and reproduction

Identity and transfer of male reproductive gland proteins of the dengue vector mosquito, Aedes aegypti: Potential tools for control of female feeding and reproduction

Mycobacterium aviumsubsp.paratuberculosisin Veterinary Medicine

Dependence of Staphylococcus epidermidis on non-transferrin-bound iron for growth

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