Iron in Nutrition Vii. Copper as a Supplement to Iron for Hemoglobin Building in the Rat

Hart, E. B.; Steenbock, H.; Waddell, J.; Elvehjem, C. A.

doi:10.1111/j.1753-4887.1987.tb06082.x

Cited by 36 publications

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“…Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. rat work at the University of Wisconsin (Hart et al, 1928). However, a role for Cu in explaining anemia was suggested in humans 80 years earlier (Fox, 2003).…”

Section: Introductionmentioning

confidence: 99%

Copper deficient rats and mice both develop anemia but only rats have lower plasma and brain iron levels

Pyatskowit

Prohaska

2008

Comparative Biochemistry and Physiology Part C: Toxicology &

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Iron homeostasis depends on adequate dietary copper but the mechanisms are unknown. Mice (Mus musculus) and rat (Rattus norvegicus) offspring were compared to determine the effect of dietary copper deficiency (Cu-) on iron status of plasma, liver, brain and intestine. Holtzman rat and Hsd:ICR (CD-1) outbred albino mouse dams were fed a Cu-diet and drank deionized water or Cu supplemented water. Offspring were sampled at time points between postnatal ages 13 and 32. Curat and mouse pups were both anemic, but only rat pups had lower plasma and brain iron levels. Plasma iron was lower throughout the suckling period in Cu-rats but not Cu-mice. Cu-mice derived from dams restricted of Cu only during lactation were also severely anemic without hypoferremia. Intestinal metal analysis confirmed that Cu-pups had major reductions in intestinal concentration of Cu, increased Fe, and normal Zn. However, whole mouse (less the intestine) analysis demonstrated normal content of Fe indicating that the limitation in iron transport by intestinal hephaestin had no consequence to total iron reserves of the mouse. Further research will be needed to determine the reason Cu-mice were anemic since the "ferroxidase" hypothesis does not explain this phenotype.

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Section: Introductionmentioning

confidence: 99%

Copper deficient rats and mice both develop anemia but only rats have lower plasma and brain iron levels

Pyatskowit

Prohaska

2008

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…In addition to Fe and folic acid, lucerne leaf concentrate contains nutritionally beneficial amounts of b-carotene (54 % of RDA), vitamin E (66 % of RDA), Ca (26 % of RDA) and Cu (8 % of RDA; Table 1). Evidence for synergistic effects of these micronutrients on Fe and folic acid supplementation for the treatment of anaemia is inconsistent (15)(16)(17)(18)(19) , although it is known that Cu has a role in haematopoiesis (20) and vitamin A and b-carotene have been shown to improve Fe absorption, possibly by preventing the inhibitory effects of phytates and polyphenols (21,22) . Regardless of these possible synergies, it is indisputable that girls approaching childbearing age would benefit from the correction of other prevalent nutritional deficiencies, particularly of vitamin A (23)(24)(25)(26)(27) and Ca (28) .…”

Section: Discussionmentioning

confidence: 99%

Leaf concentrate as an alternative to iron and folic acid supplements for anaemic adolescent girls: a randomised controlled trial in India

Vyas

Collin

Bertin

et al. 2009

Public Health Nutr.

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Objective: Despite public health campaigns based on Fe and folic acid supplements, Fe-deficiency anaemia remains highly prevalent among women in India. We investigated leaf concentrate as an alternative to Fe and folic acid supplements for treating anaemia in adolescent girls. Design: Randomised controlled two-arm trial over 3 months: one group received daily Fe and folic acid (IFA; 60 mg Fe, 500 mg folic acid); the other daily leaf concentrate (LC; 5 mg Fe, 13 mg folic acid). Hb concentration, mean cell volume, serum Fe, serum ferritin and total Fe-binding capacity were measured pre-and post-intervention. Setting: Jaipur, India. Subjects: One hundred and two adolescent girls aged 14-18 years. Results: Of the 102 girls randomized to the two arms of the trial, four (3?9 %) were severely anaemic (Hb , 7 g/dl), twenty-eight (27?5 %) were moderately anaemic (Hb $ 7 g/dl, ,10 g/dl) and seventy (68?6 %) were mildly anaemic (Hb $ 10 g/dl, ,12 g/dl). In the IFA group, eleven girls (20?4 %) withdrew due to side-effects, compared with one girl (2?1 %) in the LC group (P 5 0?005). Total losses to followup were 14/54 in the IFA group and 2/48 in the LC group. At the end of the trial, none of the eighty-six remaining girls were severely anaemic, nine (10?5 %) were moderately anaemic and twenty-six (30?2 %) were mildly anaemic; fifty-one (59?3 %) had normal Hb levels ($12 g/dl). After adjustment for baseline values, LC was as effective as IFA in improving serum Fe parameters and treating anaemia. Conclusions: Leaf concentrate is an effective, and more palatable, alternative to Fe and folic acid supplements for treating anaemia in adolescent girls.

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“…Copper's essentiality was first discovered in 1928, when it was demonstrated that rats fed with copper-deficient milk diet were unable to produce sufficient red blood cells. 4 Cataract is clouding of the lens in the eye leading to a decrease in vision. It can affect one or both eyes.…”

Section: Introductionmentioning

confidence: 99%

Serum zinc and copper levels: a marker of disease activity in senile cataract patients

et al. 2017

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Background: The present study was aimed to study alterations in levels of zinc and copper in senile cataract patients.Methods: 25 senile cataract patients in age group of 50 to 80 years and 25 control group were included in the study. Serum zinc and copper levels were determined by colorimetric method.Results: Significantly increased levels of serum zinc in cataract patients (199.8±24.32 µg/dl) were found as compared to controls (85.80±3.6 µg/dl) (p<0.0001). Serum copper concentration in cataract patients (249.5±34.59 µg/dl) were significantly (<0.0001) increased when compared to controls (125.7±4.66 µg/dl).Conclusions: Copper and zinc are involved in the pathogenesis of cataracts by different mechanisms such as damaging lipid membranes and lens capsule, crosslinking and in solubilization of lens proteins, leakage of beta and gamma crystalline into the aqueous humour through the production of hydroxyl radicals and peroxyl radicals. So, abnormal elevation of serum copper and zinc can be used as a marker in the opacification of the lens cortex in age-related human cataract.

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Iron in Nutrition Vii. Copper as a Supplement to Iron for Hemoglobin Building in the Rat

Cited by 36 publications

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Copper deficient rats and mice both develop anemia but only rats have lower plasma and brain iron levels

Copper deficient rats and mice both develop anemia but only rats have lower plasma and brain iron levels

Leaf concentrate as an alternative to iron and folic acid supplements for anaemic adolescent girls: a randomised controlled trial in India

Serum zinc and copper levels: a marker of disease activity in senile cataract patients

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