Iron(III) chloride catalysed three-component Grieco condensation: Synthesis of tetrahydropyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidines/quinazolines

Synthesis of Pyrazolo[3,4-b]Pyridine and Pyrido[2′,3′:3,4]Pyrazolo [1,5-a]Pyrimidine Derivatives

“…16,17 The combination of pyridine, pyrazole and pyrimidine ring systems to give the tricyclic pyrido [2p,3p:3,4]pyrazolo [1,5-a]pyrimidines and the subsequent influence on biological activity is of current interest. [18][19][20] Some derivatives of pyrido[2p,3p:3,4]pyrazolo [1,5-a]pyrimidine were reported to have cytotoxic activity. 6 In the light of these findings, We aimed to synthesise new pyrazolo [3,4-b]pyridine derivatives starting from pyrazole or pyridine ring systems to be used as antimicrobial agents.…”

Microwave-Assisted Synthesis of Quinazolines and Quinazolinones: An Overview

“…Transition metal catalysis has also found extensive applications in the convenient and efficient synthesis of a wide variety of heterocyclic systems (Ma et al, 2017 ; Ramanathan and Liu, 2017 ; Tiwari and Bhanage, 2017 ; Chatterjee et al, 2018 ; Saikia et al, 2018 ; Chen et al, 2020 ; Debabrata et al, 2020 ; Ghosh et al, 2020 ; Janardhanan et al, 2020 ; Jiang et al, 2020 ; Kanwal et al, 2020 ; Kojima and Matsunaga, 2020 ; Li and Zhang, 2020 ; Nagata and Obora, 2020 ; Neto and Zeni, 2020a , b ; Pal et al, 2020 ; Ratmanova et al, 2020 ; Sahiba and Agarwal, 2020 ; Sonawane et al, 2020 ; Xuan et al, 2020 ). However, the literature survey revealed only an example of zinc (Shi et al, 2004 ), a limited number of iron-catalyzed (Melvin et al, 1992 ; Valderrama et al, 1999 ; Kanth et al, 2006 ; Yin et al, 2012 ; Gopalaiah et al, 2017 , 2019 ; Raut and Bhanage, 2017 ; Eidi et al, 2018 ), and relatively more copper-catalyzed reactions, leading to the synthesis of quinazoline and quinazolinone derivatives (Melvin et al, 1992 ; Chatterjee et al, 2018 ; Potuganti et al, 2018 ; Liang et al, 2019 ; Rodrigues et al, 2019 ; Donthiboina et al, 2020 ). The number of zinc, iron, and copper-catalyzed synthesis of quinazoline and quinazolinone derivatives were decreased when the literature survey was narrowed down to the choice of those reactions, performed specifically under MWI as an unconventional and environmentally benign source of energy, in accordance with the title of this review.…”

Synthesis, Characterization, and In Vitro Antibacterial Activities of Macromolecules Derived from Bis‐Chalcone

“…Among the heterocycles, pyrazoline and pyrazole are a class of compounds with biological activities, such as antimicrobial , antitumor , antioxidant , calcium channel modulators , and antipyretic . On the other hand, the classes of pyrimidines possess a broad spectrum of biological effectiveness such as antitubercular , calcium channel blockers , and many classes of chemotherapeutic agents containing pyrimidine nucleus are in clinical use. Apart from these, we derived the pyrazoline, pyrazole, and pyrimidines from the chalcone as a antibacterial agents.…”