Iron, Hepcidin and Inflammatory Status of Young Healthy Overweight and Obese Women in Australia

Cheng, Hoi Lun; Bryant, Christian; Rooney, Kieron; Steinbeck, Katharine; Griffin, Hayley; Petocz, Peter; O’Connor, Helen

doi:10.1371/journal.pone.0068675

Cited by 41 publications

(37 citation statements)

References 23 publications

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“…Iron concentrations at steady-state were also affected by body size, as we found that iron absorption decreased when the body mass index increased. This result was observed in several studies revealing that iron concentration was lower for people with a high body mass index (36,37). A study performed on women aged between 18 to 25 years with a measured BMI ≥27.5 kg/ m 2 revealed the presence of inflammation with increasing body mass index.…”

Section: Discussionsupporting

confidence: 57%

Joint Model of Iron and Hepcidin During the Menstrual Cycle in Healthy Women

Angeli

Lainé

Lavenu

et al. 2016

AAPS J

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Abstract. Hepcidin regulates serum iron levels, and its dosage is used in differential diagnostic of iron-related pathologies. We used the data collected in the HEPMEN (named after HEPcidin during MENses) study to investigate the joint dynamics of serum hepcidin and iron during the menstrual cycle in healthy women. Ninety menstruating women were recruited after a screening visit. Six fasting blood samples for determination of iron-status variables were taken in the morning throughout the cycle, starting on the second day of the period. Non-linear mixed effect models were used to describe the evolution of iron and hepcidin.Demographic and medical covariates were tested for their effect on model parameters. Parameter estimation was performed using the SAEM algorithm implemented in the Monolix software. A general pattern was observed for both hepcidin and iron, consisting of an initial decrease during menstruation, followed by a rebound and stabilising during the second half of the cycle. We developed a joint model including a menstruation-induced decrease of both molecules at the beginning of the menses and a rebound effect after menses. Iron stimulated the release of hepcidin. Several covariates, including contraception, amount of blood loss and ferritin, were found to influence the parameters. The joint model of iron and hepcidin was able to describe the fluctuations induced by blood loss from menstruation in healthy non-menopausal women and the subsequent regulation. The HEPMEN study showed fluctuations of iron-status variables during the menstrual cycle, which should be considered when using hepcidin measurements for diagnostic purposes in women of child-bearing potential.

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Section: Discussionsupporting

confidence: 57%

Joint Model of Iron and Hepcidin During the Menstrual Cycle in Healthy Women

Angeli

Lainé

Lavenu

et al. 2016

AAPS J

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“…This data was consistent with morbid obesity as described in others studies (2,18,19,36). A previous study has shown a correlation between hepcidin and ferritin values prior to surgery and a reduction of inflammation 6 months after surgery was associated with hepcidin and sTfR reductions (18).…”

Section: Discussionsupporting

confidence: 91%

Micronutrient supplementation in gastric bypass surgery: prospective study on inﬂammation and iron metabolism in premenopausal women

et al. 2017

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Marin FA, Verlengia R, Crisp AH, Sousa Novais PF, Rasera-Junior I, de Oliveira MR. Micronutrient supplementation in gastric bypass surgery: prospective study on infl ammation and iron metabolism in premenopausal women. Nutr Hosp 2017;34:369-375 DOI: http://dx.doi.org/10.20960/nh.1162 Paulo -FAPESP (Process no. 2012/18719-9) and Conselho Nacional de Desenvolvimento Científi co e Tecnológico -CNPq (Processs no. 142828/2011-4 Financial support: Fundação de Amparo à Pesquisa do Estado de São AbstractBackground: Low-grade chronic infl ammation in morbid obesity is associated with impaired iron metabolism. Bariatric surgery is effective in weight loss; however, it can induce specifi c nutritional defi ciencies, such as iron, especially in premenopausal women. Alternatively, after surgery, there is an improvement in systemic infl ammation, raising questions concerning the dosages of micronutrient supplementation. Objectives: This study aimed to assess the effect of two micronutrient supplementation schemes before and 6 months after a Roux-en-Y gastric bypass (RYGB) surgery on infl ammation and iron metabolism in premenopausal women.

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“…In another study by Pinhas Hamiel et al [13], an association was found between BMI and serum iron. Also, Cheng et al [14] indicated the prevalence of anemia and iron deficiency as 10% and 17%, respectively. In their study, BMI could predict lower levels of serum iron, TIBC, and also CRP.…”

Section: Discussionmentioning

confidence: 99%

Iron deficiency anemia and megaloblastic anemia in obese patients

Arshad

Jaberian

Pazouki

et al. 2017

Romanian Journal of Internal Medicine

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Background. The association between obesity and different types of anemia remained uncertain. The present study aimed to assess the relation between obesity parameters and the occurrence of iron deficiency anemia and also megaloblastic anemia among Iranian population.Methods and Materials. This cross-sectional study was performed on 1252 patients with morbid obesity that randomly selected from all patients referred to Clinic of obesity at Rasoul-eAkram Hospital in 2014. The morbid obesity was defined according to the guideline as body mass index (BMI) equal to or higher than 40 kg/m 2 . Various laboratory parameters including serum levels of hemoglobin, iron, ferritin, folic acid, and vitamin B12 were assessed using the standard laboratory techniques.Results. BMI was adversely associated with serum vitamin B12, but not associated with other hematologic parameters. The overall prevalence of iron deficiency anemia was 9.8%. The prevalence of iron deficiency anemia was independent to patients' age and also to body mass index. The prevalence of vitamin B12 deficiency was totally 20.9%. According to the multivariable logistic regression model, no association was revealed between BMI and the occurrence of iron deficiency anemia adjusting gender and age. A similar regression model showed that higher BMI could predict occurrence of vitamin B12 deficiency in morbid obese patients.Conclusion. Although iron deficiency is a common finding among obese patients, vitamin B12 deficiency is more frequent so about one-fifth of these patients suffer vitamin B12 deficiency. In fact, the exacerbation of obesity can result in exacerbation of vitamin B12 deficiency.

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Iron, Hepcidin and Inflammatory Status of Young Healthy Overweight and Obese Women in Australia

Cited by 41 publications

References 23 publications

Joint Model of Iron and Hepcidin During the Menstrual Cycle in Healthy Women

Joint Model of Iron and Hepcidin During the Menstrual Cycle in Healthy Women

Micronutrient supplementation in gastric bypass surgery: prospective study on inﬂammation and iron metabolism in premenopausal women

Iron deficiency anemia and megaloblastic anemia in obese patients

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