Joint Model of Iron and Hepcidin During the Menstrual Cycle in Healthy Women

Angeli, Adeline; Lainé, Fabrice; Lavenu, Audrey; Ropert, Martine; Lacut, Karine; Gissot, Valérie; Sacher‐Huvelin, Sylvie; Jézéquel, Caroline; Moignet, Aline; Laviolle, Bruno; Comets, Emmanuelle

doi:10.1208/s12248-016-9875-4

Cited by 19 publications

(20 citation statements)

References 41 publications

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“…Angeli et al. (2016) showed that iron status varies during the menstrual cycle, and this should thus be considered when using hepcidin as a diagnostic measure for WCA 36 . In the present study, 43 (64.2%) subjects claimed that they had regular menstrual cycles.…”

Section: Discussionsupporting

confidence: 44%

Iron status and hepcidin levels as potential regulators of haemoglobin homeostasis in overweight and obese women of childbearing age

Insani

Subagio

Hendrianingtyas

2019

Journal of Taibah University Medical Sciences

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ObjectivesOverweight is considered a risk factor for anaemia. However, the mechanisms underlying anaemia development in overweight and obese people remain unclear. This study analysed the correlation of iron status (soluble transferrin receptor [sTfR]/log ferritin ratio) and hepcidin levels with haemoglobin (Hb) levels in overweight and obese women of childbearing age.MethodsIn this cross-sectional study, we recruited 66 women aged 20–29 years with a body mass index ≥23 kg/m2. We gathered data on informed consent, demographic characteristics, questionnaire responses, anthropometric and laboratory values. A Spearman correlation test was performed to determine the correlation.ResultsThe mean levels of ferritin and sTfR were 10.2 ± 8.12 and 22.2 ± 7.96 ng/ml, respectively, and the mean sTfR/log ferritin ratio was 29.3 ± 17.65 nmol/L. The mean hepcidin levels were 9.0 ± 3.05 ng/ml. In total, 75.8% of subjects had low ferritin levels, high sTfR (51.5%) levels, and a high sTfR/log ferritin ratio (87.9%). The sTfR levels (r = −0.359; p = 0.003) and sTfR/log ferritin ratio (r = −0.375; p = 0.002) were negatively correlated with Hb levels. There was no correlation between the levels of hepcidin and Hb (r = −0.140; p = 0.264), but there was a positive correlation between ferritin and Hb levels (r = 0.350; p = 0.004).ConclusionThis study showed a correlation between iron status and Hb levels in overweight and obese women of childbearing age. All the women had erythropoiesis with iron deficiency anaemia. We recommend that overweight and obese women undergo further iron parameters for the detection of early anaemia. In this group, the consumption of foods that enhance iron absorption, such as ascorbic acid, should be encouraged.

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Section: Discussionsupporting

confidence: 44%

Iron status and hepcidin levels as potential regulators of haemoglobin homeostasis in overweight and obese women of childbearing age

Insani

Subagio

Hendrianingtyas

2019

Journal of Taibah University Medical Sciences

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“…As hepcidin and iron parameters vary during the menstrual cycle , only healthy male volunteers were included. They were medication‐free, nonsmokers, and they did not have excessive alcohol consumption (i.e., more than 30 g of alcohol per day).…”

Section: Methodsmentioning

confidence: 99%

Curcuma decreases serum hepcidin levels in healthy volunteers: a placebo‐controlled, randomized, double‐blind, cross‐over study

Lainé

Laviolle

Bardou-Jacquet

et al. 2017

Fundamemntal Clinical Pharma

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Hepcidin, secreted by hepatocytes, controls iron metabolism by limiting iron egress in plasma. Hepcidin is upregulated during inflammation through the activation of the signal transducer and activator of transcription 3 (STAT3) transduction pathway, which decreases iron bioavailability and may explain the anemia of chronic inflammatory disease. In vitro, it has been shown that curcumin can decrease hepcidin synthesis by decreasing STAT3 activity. We conducted a proof-of-concept study to assess the effect of curcuma on hepcidin synthesis in human. This was a placebo-controlled, randomized, double-blind, cross-over, two-period study performed in 18 healthy male volunteers. Subjects received a single oral dose of 6 g curcuma containing 2% of curcumin or placebo. Serum hepcidin and iron parameters were assessed repeatedly until 48 h after dosing. When compared with a placebo curcuma decreased hepcidin levels significantly at 6 h (-19%, P = 0.004), 8 h (-17%, P = 0.009), and 12 h (-17%, P = 0.007) and tended to decrease hepcidin at 24 h (-15%, P = 0.076). Curcuma also significantly increased serum ferritin levels at 6 and 8 h (+7% for both times, P = 0.018, 0.030, respectively) and had no effects on serum iron, transferrin, and transferrin saturation. This pilot study showed that curcuma decreases serum hepcidin levels in human and supports the idea that curcuma could be useful in treating hepcidin overproduction during inflammatory processes. Confirmatory studies in patients with chronic inflammation are now required to determine the optimal dose and therapeutic scheme of curcuma.

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“…Other areas that should be explored in the future include quantifying the influence of the menstrual cycle and the use of hormonal birth control on iron biomarkers within the context of obesity. For instance, the menstrual cycle has been reported to impact systemic iron homeostasis including hepcidin and serum iron [ 53 ] but blood collection for this study was not timed to the cycle phase. It is unknown how much of the differences or lack thereof in iron markers in the present study could be attributed to the time within the menstrual cycle blood samples were collected.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Markers and Hepcidin are Elevated but Serum Iron is Lower in Obese Women of Reproductive Age

Aguree

Reddy

2021

Nutrients

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Limited evidence suggests that serum iron and hepcidin concentrations are dysregulated in obesity and inflammation. The objective of the present study was to compare C-reactive protein, interleukin-6, circulating levels of hepcidin, serum lipids, and iron status in obese vs. normal-weight women of childbearing age. Healthy women aged 18–30 years were recruited for the study (n = 47: 25 obese and 22 normal weight). Fasting blood samples were obtained to measure serum lipids (total cholesterol, HDL, LDL cholesterol, triglycerides, non-HDL cholesterol), complete blood count, serum iron, total iron-binding capacity, transferrin saturation, serum ferritin, hepcidin, C-reactive protein, and interleukin-6. Obese women had significantly higher mean serum C-reactive protein (p < 0.001), interleukin-6 (p < 0.001), hepcidin (p = 0.024), triglycerides (p < 0.001) and total cholesterol/HDL ratio (p < 0.001) but lower HDL (p = 0.001) and serum iron/hepcidin ratio (p = 0.011) compared with normal-weight women. BMI correlated positively with inflammatory markers, triglycerides, LDL and total cholesterol/HDL ratio, and negatively with HDL and serum iron/hepcidin ratio. Serum iron correlated negatively with ferritin in the obese group (p = 0.030) but positively in normal weight women (p = 0.002). BMI and ferritin were the only predictors of serum iron/hepcidin ratio accounting for 23% of the variation among subjects. Studies are needed to examine anti-inflammatory dietary approaches that can improve iron biomarkers in obese women.

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Joint Model of Iron and Hepcidin During the Menstrual Cycle in Healthy Women

Cited by 19 publications

References 41 publications

Iron status and hepcidin levels as potential regulators of haemoglobin homeostasis in overweight and obese women of childbearing age

Iron status and hepcidin levels as potential regulators of haemoglobin homeostasis in overweight and obese women of childbearing age

Curcuma decreases serum hepcidin levels in healthy volunteers: a placebo‐controlled, randomized, double‐blind, cross‐over study

Inflammatory Markers and Hepcidin are Elevated but Serum Iron is Lower in Obese Women of Reproductive Age

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