Iron chelation prevents lung injury after major hepatectomy

Kalimeris, Konstantinos; Nastos, Constantinos; Papoutsidakis, Nikolaos; Xanthopoulou, Marianna N.; Defterevos, George; Tympa, Aliki; Pafiti, Agathi; Andreadou, Ioanna; Kostopanagiotou, Georgia; Smyrniotis, Vassilios; Arkadopoulos, Nikolaos

doi:10.1111/j.1872-034x.2010.00682.x

Cited by 11 publications

(22 citation statements)

References 38 publications

(104 reference statements)

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“…6,7 Understanding the degree of oxygen radicals is believed to be a problem connected directly to the therapeutic strategies of IRI. However, at present, it is difficult to directly measure the oxygen radicals produced in vivo, and a new blood parameter to reflect the level of oxygen radicals is needed.…”

Section: Discussionmentioning

confidence: 99%

“…The severity of IRI is associated with the graft function after LT. 4,[24][25][26][27] In addition, IRI influences the functions of many remote organs. 6,7,28 Therefore, it is important that the degree of IRI can be precisely determined in order to predict the extent of injury to other organs. Because measuring the SF level is minimally invasive, easy, and economical, it has the potential to be useful to assess the degree of IRI.…”

Section: Discussionmentioning

confidence: 99%

“…31,32 There have also been many reports about lung injury caused by oxygen radicals. 6,7,33,34 Therefore, it is necessary to recognize that a recipient with a high SF value during LT may be at a high risk of acute lung injury. In this study, it is speculative whether the SF level is actually pathophysiologically related to a prolonged intubation time, and further studies on this issue are required in the future.…”

Section: Discussionmentioning

confidence: 99%

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Impact of the serum ferritin concentration in liver transplantation

Wakiya

Sanada²,

Urahashi³

et al. 2015

Liver Transpl

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The serum ferritin (SF) concentration is a widely available and objective laboratory parameter. SF is also widely recognized as an acute-phase reactant. The purpose of the present study was to identify the chronological changes in the recipient's SF concentration during liver transplantation (LT) and to clarify factors having an effect on the recipient's intraoperative SF level. In addition, the study retrospectively evaluated the usefulness of measuring SF during LT. Ninety-eight pediatric recipients were retrospectively analyzed. The data were analyzed and compared according to the SF level in the recipient. Patients were classified into 2 groups based on the intraoperative peak SF levels of ≤ 1000 ng/mL (low-SF group) or >1000 ng/mL (high-SF group). The SF value increased dramatically after reperfusion and fell to normal levels within the early postoperative period. The warm ischemia time (WIT) was significantly longer in the high-SF group (47.0 versus 58.5 minutes; P = 0.003). In addition, a significant positive correlation was observed between the peak SF value and WIT (r = 0.35; P < 0.001). There were significant positive correlations between the peak SF value and the donors' preoperative laboratory data, including transaminases, cholinesterase, hemoglobin, transferrin saturation, and SF, of which SF showed the strongest positive correlation (r = 0.74; P < 0.001). The multivariate analysis revealed that WIT and donor's SF level were a significant risk factor for high SF level in the recipient (P = 0.007 and 0.02, respectively). In conclusion, the SF measurement can suggest the degree of ischemia/reperfusion injury (IRI). A high SF level in the donor is associated with the risk of further acute reactions, such as IRI, in the recipient.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Impact of the serum ferritin concentration in liver transplantation

Wakiya

Sanada²,

Urahashi³

et al. 2015

Liver Transpl

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“…Similarly, in a prospective, randomized, double-blinded, placebo-controlled study that included critically ill patients with hypotension, Fraga et al reported that the use of NAC plus desferoxamine decreased the oxidative damage parameters but not plasma IL-6 levels [15]. In an experimental pig model combining liver resection with prolonged ischaemia, administration of desferoxamine during reperfusion of the remnant liver was associated with an increase in serum IL-6, and was significantly higher after 12 h compared to controls [16]. Of note, increased doses of IL-6 during liver I/R have been reported to protect the liver from damage via its anti-inflammatory effects, as well as via TNF-a reduction [17].…”

Section: Discussionmentioning

confidence: 97%

The effects of n-acetylcysteine and desferoxamine on IL-6, TNF-a, and oxLDL after infrarenal aortic clamping

Katseni¹,

Chalkias

Kaparos³

et al. 2015

Hellenic J Surg

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Aim-Background: Treatment of abdominal aortic aneurysms remains a challenging task. We examined the effects of n-acetylcysteine and desferoxamine on interleukin-6, tumour necrosis factor-a, and oxidized low density lipoprotein after infrarenal aortic clamping.Methods: Fifteen piglets were assigned to three groups. The control group (Group C) received saline as placebo (10-mL dilution, bolus), whereas the Group of n-acetylcysteine (Group NAC) received 150mg/kg IV n-acetylcysteine 30 min prior to aortic clamping and 50mg/kg/h after its release (reperfusion). The desferoxamine group (Group D) received IM 100mg/kg/d desferoxamine for 3 days prior to the experiment.Results: Interleukin-6 increased significantly one hour after aortic clamping, while administration of desferoxamine and n-acetylcysteine had no effect on its production. Tumour necrosis factor-a increased after aortic clamping and failed to normalise during the experiment in all groups. At 2 hours post-reperfusion, desferoxamine had a modest effect on tumour necrosis factor-a values, while in Group NAC, tumour necrosis factor-a had decreased by 50% at 10 min post-reperfusion. Oxidized low density lipoprotein in Group C did not increase significantly from baselines values. In Groups D and NAC, oxidized low density lipoprotein had increased at 10 min post-reperfusion, after which it progressively decreased until 2 hours post-reperfusion.Conclusions: Interleukin-6 and tumour necrosis factor-a increased significantly after aortic clamping. Administration of desferoxamine and n-acetylcysteine had no effect on interleukin-6, while administration of n-acetylcysteine reduced tumour necrosis factor-a by 50% at 10 min post-reperfusion. Although in Groups D and NAC oxidized low density lipoprotein increased post-reperfusion, it progressively decreased with time.

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“…37 We have previously shown that the dosage scheme used in this study is capable of attenuating oxidative injury in the liver and the lung in a severe model of complete liver devascularization 30 as well as in the model used in this study. 23,38 Another possibility is that factors related to liver dysfunction other than oxidative mucosal injury, which could not be reversed by desferrioxamine administration, contribute to late mucosal failure.…”

Section: Discussionmentioning

confidence: 98%