Iron bioavailability from supplemented formula milk: effect of lactoferrin addition

Menéndez, Sonia; Sánchez, Marı́a Luisa Fernández; González‐Iglesias, Héctor; Fernández-Colomer, Belén; López-Sastre, José; Sanz‐Medel, Alfredo

doi:10.1007/s00394-016-1325-7

Cited by 13 publications

(8 citation statements)

References 21 publications

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“…The mathematical approach IPD applied to quantitative speciation studies using HPLC‐ICP‐MS , proved to be a very suitable tool to study iron metabolism and bioavailability in in vivo studies. The results obtained highlight that the combined use of trace element speciation with species quantification and nutrition studies via IPD with an ICP‐MS, offer a novel and powerful way for Fe metabolism.…”

Section: Discussionmentioning

confidence: 99%

“…It was suggested that lactoferrin (Lf), a major protein in human milk, could enhance iron absorption in the small intestine of infants . More recently, human milk studies have shown that iron is attached to lactoferrin apart from other proteins .…”

Section: Introductionmentioning

confidence: 99%

“…For this purpose, stable isotopes in combination with Isotope Pattern Deconvolution (IPD) and HPLC‐ICP‐MS measurements, a tool recently developed for quantitative speciation analysis , holds a great promise for metabolism and nutritional trace element studies because it allows to obtain this quantitative information easily. Mineral metabolism of a trace element can be studied in combination with two enriched tracers: a metabolic tracer (used for feeding) and a quantification tracer (added after collecting the samples . Quantitative information is obtained by integration of the relative molar‐flow chromatograms, after separation by HPLC and, therefore, important metabolic information can be obtained as every measurement provides both, the total metal concentration values and the tracer/tracee ratios by ICP‐MS measurements .…”

Section: Introductionmentioning

confidence: 99%

“…In order to shed light on the real effect of Lf presence on iron absorption , selected formula milks were fortified with iron (“exogenous”, isotopically enriched) in two different ways: as the 57 Fe(III)‐Lf complex or, alternatively, as just the reference 57 Fe(II)SO 4 species (at different iron doses) to which a given amount of lactoferrin had been added. Quantitative speciation of iron (natural and exogenous) in rats was carried out in the three selected rat body compartments (red blood cells, serum and liver) using iron speciation by HPLC‐ICP‐MS and IPD for the quantification of Fe species.…”

Section: Introductionmentioning

confidence: 99%

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In vivo study of the effect of lactoferrin on iron metabolism and bioavailability from different iron chemical species for formula milk fortification

et al. 2017

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Iron fortification in infant formulas is a common practice for providing iron to newborns in order to avoid its deficiency (anemia). Depending on the physicochemical species used, its bioavailability might be insufficient to meet iron requirements. In this vein, the influence of Lactoferrin (Lf) presence on iron bioavailability in 2-week-old wistar rats fed with formula milk fortified with Fe(III) -Lf or Fe(II)SO (in presence of Lf) using quantitative speciation (by HPLC-ICP-MS) and Isotope Pattern Deconvolution (IPD) is studied here. Results obtained were compared among fortifiers and also with the maternal group. In RBCs, iron was mainly bound to hemoglobin in all the assayed groups in the same extent. Regarding serum samples, several iron-proteins were observed (such as transferrin and albumin). In both samples, iron content in the fractions studied was similar in all groups compared and exogenous Fe incorporation of intaked iron was always above 50%, showing no significative differences between physicochemical forms but related to the dose administered. Regarding iron stores (liver) the group fed with formula milk fortified with the higher dose of FeSO in presence of Lf presented the highest values of total iron even superior than those found in the maternal group, and also the highest exogenous ( Fe) incorporation. In conclusion, it was proved that iron fortification is required to ensure proper iron levels in all body compartments. No significative differences were observed between different physicochemical species when iron is administered at low doses. However, higher iron doses lead to a greater incorporation in all the iron-proteins studied.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In vivo study of the effect of lactoferrin on iron metabolism and bioavailability from different iron chemical species for formula milk fortification

et al. 2017

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“…A significant omission is the fact that there are no comprehensive data on the clinical significance of lactoferrin (LF) -a protein with unique biological properties that participates in iron metabolism, immune response modeling, growth factor regulation in relation to patients with PC [14,15].…”

Section: Introductionmentioning

confidence: 99%

Relationship aggressiveness of prostate cancer with tumor-associated serum markers

Lozovska¹,

Naleskina²,

Zadvorniy³

et al. 2019

Fiziol Zh

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The content of lactoferrin (LF), C-reactive protein (CRP), albumin, lactate dehydrogenase (LDH), as well as Ca/Mg and CRP/albumin ratios in sera of patients with prostate cancer were analyzed in relation to the clinical and pathological features of the disease including the malignancy degree (Gleason score) and the presence of metastases to regional lymph nodes. In the serum of patients with stage III, LF content was lower (1.4 times) and CRP/albumin ratio <0.5 than in patients with stage II, while CRP content and Ca/Mg ratio increased (2.75 and 1.12 times, respectively). In addition, in patients with metastatic lesions of regional lymph nodes, a decrease in LF content (1.3-fold) and level of albumin (1.16-fold) and a simultaneous increase in CRP, Ca/Mg (2.84 and 1.1 times, respectively) and CRP/albumin ratios lower (<0.5) were evident. In serum of patients with tumors of high malignancy degree (8 and 9 points by Gleason score) and prostatespecific antigen (PSA) level exceeding 4 ng/ml, LF content and CRP/albumin ratio decreased whereas CRP content and Ca/Mg ratio were increased, LDH activity in serum of these patients also increased significantly. Therefore, some differences in metabolic pathways in patients with prostate cancer of highly aggressive course have been elucidated. Comparative study of the content of extratumoral serum PC markers (LF, PSA, albumin, LDH, Ca/Mg, CRP/albumin), depending on the clinical manifestations of the tumor process showed that serum LF can be used as an extratumoral marker, which provides new additional information on the features of the clinical course of the disease.

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Effect of holder pasteurisation on total concentrations and iron-binding profiles of holo -lactoferrin used as fortifier in donor human milk

Menéndez

Peixoto

Fernández-Colomer

et al. 2020

International Dairy Journal

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Iron bioavailability from supplemented formula milk: effect of lactoferrin addition

Abstract: Considering the results obtained, supplementation with iron salts in excess of Lf appears to be the best way of iron supplementation of formula milk.

Cited by 13 publications

References 21 publications

In vivo study of the effect of lactoferrin on iron metabolism and bioavailability from different iron chemical species for formula milk fortification

In vivo study of the effect of lactoferrin on iron metabolism and bioavailability from different iron chemical species for formula milk fortification

Relationship aggressiveness of prostate cancer with tumor-associated serum markers

Effect of holder pasteurisation on total concentrations and iron-binding profiles of holo -lactoferrin used as fortifier in donor human milk

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