Iron administration reduces airway hyperreactivity and eosinophilia in a mouse model of allergic asthma

Maazi, Hadi; Shirinbak, Soheila; Bloksma, N.; Nawijn, Martijn C.; Oosterhout, Antoon J. M. van

doi:10.1111/j.1365-2249.2011.04448.x

Cited by 38 publications

(22 citation statements)

References 28 publications

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“…These studies show that dietary iron supplementation decreased the severity of allergic asthma in wild type mice, as measured by significant decreases in infiltration of eosinophils and secretion of proinflammatory cytokines and chemokines into bronchoalveolar spaces, confirming in part similar results recently reported by Maazi et al [23]. In addition, we made the novel observation using a direct measure of airflow resistance that supplementation attenuates the acute development of airway hyperresponsiveness in the common ovalbumin model of allergic asthma.…”

Section: Discussionsupporting

confidence: 92%

Iron Supplementation Decreases Severity of Allergic Inflammation in Murine Lung

et al. 2012

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The incidence and severity of allergic asthma have increased over the last century, particularly in the United States and other developed countries. This time frame was characterized by marked environmental changes, including enhanced hygiene, decreased pathogen exposure, increased exposure to inhaled pollutants, and changes in diet. Although iron is well-known to participate in critical biologic processes such as oxygen transport, energy generation, and host defense, iron deficiency remains common in the United States and world-wide. The purpose of these studies was to determine how dietary iron supplementation affected the severity of allergic inflammation in the lungs, using a classic model of IgE-mediated allergy in mice. Results showed that mice fed an iron-supplemented diet had markedly decreased allergen-induced airway hyperreactivity, eosinophil infiltration, and production of pro-inflammatory cytokines, compared with control mice on an unsupplemented diet that generated mild iron deficiency but not anemia. In vitro, iron supplementation decreased mast cell granule content, IgE-triggered degranulation, and production of pro-inflammatory cytokines post-degranulation. Taken together, these studies show that iron supplementation can decrease the severity of allergic inflammation in the lung, potentially via multiple mechanisms that affect mast cell activity. Further studies are indicated to determine the potential of iron supplementation to modulate the clinical severity of allergic diseases in humans.

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Section: Discussionsupporting

confidence: 92%

Iron Supplementation Decreases Severity of Allergic Inflammation in Murine Lung

et al. 2012

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“…However, whilst there are some animal and human data suggesting that iron deficiency may increase Th2 cytokine responses, [25][26][27] other studies have not confirmed this. 28,29 Furthermore, interpretation of the direction of iron-cytokine associations is complicated by the fact that Th1 and Th2 cytokines can influence iron metabolism. 30,31 Regarding the weak evidence linking lower maternal haemoglobin and anaemia to lower lung function, especially FVC, in the offspring, there is some evidence from animal experiments suggesting that an adequate supply of iron is needed for optimal lung development.…”

Section: Mechanismsmentioning

confidence: 99%

Haemoglobin concentrations in pregnancy and respiratory and allergic outcomes in childhood: Birth cohort study

Shaheen

Macdonald‐Wallis

Lawlor

et al. 2017

Clin Experimental Allergy

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SummaryBackgroundLimited epidemiological evidence suggests that low maternal iron status and anaemia in pregnancy may increase the risk of childhood respiratory and allergic outcomes.ObjectivesTo investigate the relation between maternal haemoglobin concentrations in pregnancy and childhood respiratory and allergic outcomes.MethodsIn the Avon Longitudinal Study of Parents and Children (ALSPAC), we examined associations of maternal haemoglobin concentrations (g/dL) in pregnancy with hayfever, eczema, wheezing, doctor‐diagnosed asthma, allergic sensitisation and total IgE at 7 years, and with lung function at 8‐9 years in the offspring, after controlling for potential confounders (N = 3234‐5335).ResultsMaternal haemoglobin was not associated with offspring hayfever, eczema, wheezing or asthma. However, the first haemoglobin measurement in pregnancy (<18 weeks' gestation) and the last measurement (>28 weeks' gestation) were negatively associated with allergic sensitisation (adjusted odds ratio [95% CI] per g/dL 0.91 [0.83 to 0.99] and 0.90 [0.83 to 0.98], respectively). The last haemoglobin measurement was also negatively associated with total IgE (adjusted geometric mean ratio 0.94 [0.88 to 0.99]). Anaemia (haemoglobin <11 g/dL) in late pregnancy was negatively associated with forced vital capacity (difference in standard deviation score −0.07 [−0.13 to −0.01]).Conclusions and Clinical RelevanceLower maternal haemoglobin in pregnancy may be a risk factor for allergic sensitisation, elevated IgE and lower FVC in childhood, which may reflect effects of lower prenatal iron status. However, maternal haemoglobin was not associated with risk of childhood asthma or other allergic disorders.

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“…Iron supplementation reduced airway hyper-responsiveness and eosinophilia in a murine model of allergic asthma (Maazi et al, 2011). Administration of an iron chelator significantly reduced the serum IgE levels in chemically induced Th2-mediated autoimmunity in rats (Wu et al, 2004).…”

Section: Trace Elementsmentioning

confidence: 95%