Iron Supplementation Decreases Severity of Allergic Inflammation in Murine Lung

Abstract

The incidence and severity of allergic asthma have increased over the last century, particularly in the United States and other developed countries. This time frame was characterized by marked environmental changes, including enhanced hygiene, decreased pathogen exposure, increased exposure to inhaled pollutants, and changes in diet. Although iron is well-known to participate in critical biologic processes such as oxygen transport, energy generation, and host defense, iron deficiency remains common in the United States and world-wide. The purpose of these studies was to determine how dietary iron supplementation affected the severity of allergic inflammation in the lungs, using a classic model of IgE-mediated allergy in mice. Results showed that mice fed an iron-supplemented diet had markedly decreased allergen-induced airway hyperreactivity, eosinophil infiltration, and production of pro-inflammatory cytokines, compared with control mice on an unsupplemented diet that generated mild iron deficiency but not anemia. In vitro, iron supplementation decreased mast cell granule content, IgE-triggered degranulation, and production of pro-inflammatory cytokines post-degranulation. Taken together, these studies show that iron supplementation can decrease the severity of allergic inflammation in the lung, potentially via multiple mechanisms that affect mast cell activity. Further studies are indicated to determine the potential of iron supplementation to modulate the clinical severity of allergic diseases in humans.

Iron Deficiency Anemia , Serum Iron in Children With Bronchial Asthma

“…Iron deficiency was identified as a trigger for increased mast cell activation that was associated with mast cell-dependent hair loss in IL-10deficient mouse pups [11] Maazi H.et al 2011 (12)found that iron administration reduces airway hyper reactivity and eosinophilia in a mouse model of allergic asthma. Another study by Hale et al 2012 (13) found that iron supplemented diet decreased severity of allergic inflammation in murine lung. Desferrioxamine (iron chelating agent) treatment suppresses significantly immunoglobulin E (IgE) production and lymph proliferation, and possibly Th2-dominated autoimmune syndrome (14).…”

Iron Deficit Anemia As a Risk Factor of Asthma

“…Iron Deficit Anemia As a Risk Factor of Asthma Maghrib S AlKhateeb retain important anti-asthmatic effect which may be attributed to its immunomodulatory and anti-inflammatory features [4,[5][6][7][8], greater iron stocks were inversely connected with asthma and lesser body iron and higher tissue iron need were linked with lower lung function [5,7,[9][10][11][12]. Pathophysiologic occasions creating asthma, including inflammation, upsurges in Th2 cells, and muscle tightening, can associate with iron obtainability [2,3,8].…”

Evaluation of the level of reduced proteins and their recipers in the blood syrobal in children with bronchial asthma, depending on indicators of the external respiratory function

“…У разі надлишку заліза блокується взаємодія IRE з IRP, не синтезуєть ся TfR, і залізо не потрапляє в ентероцит [1]. При цьому підвищення фактора високого залі за (HFE), який зв'язує TfR, перешкоджає взає модії останнього з трансферином, не утворю ється ендосома, таким чином, залізо не прони кає в тканини [4,6].…”