Background: Asthma is a chronic inflammatory condition of the lung airways resulting in episodic airflow obstruction. iron deficiency anemia is very common public health problem in developing countries with incidence ranges from 35-90 % in developing countries and may be a risk factor for asthma in children. Objective: We investigated iron deficiency anemia, serum iron, total iron binding capacity, serum ferritin in children with bronchial asthma to study possible association of both conditions and possible role of iron deficiency anemia and iron deficiency in development of bronchial asthma and its exacerbation. Design: Case-control study. Methods: complete blood count with peripheral smear was done; C-reactive protein was determined by enzyme-linked immune-sorbent assay "high sensitive C-reactive protein". erythrocyte sedimentation rate done by Win Trobe method. Serum iron, total iron binding capacity was measured by spectrophotometer. Serum ferritin was measured by enzyme linked immune assay. Statistical analysis: Results of 40 asthmatic cases were analyzed and compared with 16 healthy controls using SPSS 20. Results: iron deficiency anemia was significantly more frequent in asthma cases compared to healthy controls. Serum iron and serum ferritin were significantly lower in asthmatic cases compared to controls .Non anemic asthmatics showed significant lower hemoglobin , serum ferritin compared with non-anemic healthy controls. Moderate cases of asthma showed significant lower hemoglobin , red cell counts , serum ferritin compared with mild cases , They did not show significant difference with severe cases in these parameters .All three groups" mild , moderate and severe" showed significant differences in these parameters. Conclusion: We conclude that iron deficiency anemia is more prevalent in asthmatic children compared to healthy controls. Asthmatic children have risk of iron deficiency even when they are not anemic. red cell counts and iron deficiency increases with severity of asthmatic attacks.
Background: Bacterial pneumonia of is common cause of pediatric mortality and hospital admission. Different risk factors for pneumonia are there. One possible risk factor is vitamin D deficiency .Objective: We determined 25 OH-vitamin D in bacterial pneumonia.to evaluate whether its level has relation to pathogenesis and management of the disease Design: case-control study Methods: 25 OH-vitamin D was determined by competitive enzyme immunoassay (EIA) commercially available kit in 36 cases with pneumonia CRP was determined by ELIZA "high sensitive CRP" .ESR done by Wintrobe method The results were analyzed and compared with 16 controls using SPSS 20 Results: Vitamin D level in pneumonia cases was significantly lower in patients compared to controls a n d s h o w e d n e g a t i v e c o r r e l a t i o n w i t h C -r e a c t i v e p r o t e i n and weak negative correlation ESR. Vitamin D did not show any relation to age, sex, weight or other clinical symptoms as dyspnea and fever Also did not show any relation to RBCs, Hb, or WBCs .Conclusion: We conclude that level of 25 OH-vitamin D is low in children with bacterial pneumonia and correlates negatively with CRP with possible relation to disease severity.
Background: Bronchial asthma is chronic inflammatory of the lung airways resulting in episodic airflow obstruction. Lead exposure results in alteration of immune system function resulting in asthma. Zinc, copper are component of antioxidant system and alteration of their level affect increase risk of asthma. Objective:. Determine the serum level of lead, zinc, copper in children with bronchial asthma and study their relation to development of asthma Patients and methods: The patient group included 38 full-term newborn infants diagnosed as having bronchial asthma who were selected from pediatric department Benha Teaching Hospital. The control group included 17 healthy child age and sex matched C-reactive protein (CRP) were measured by the ELISA technique (highly sensitive CRP). ESR was performed by the Wintrobe method, Serum lead was determined by atomic absorption method. Serum copper and zinc were determined by calorimetric method. Results: Serum copper and zinc were elevated in asthmatic children compared to controls with no relation to clinical manifestations or laboratory parameters .Serum lead showed no difference among patients and controls however it increased in severe cases compared moderate and mild cases and correlated positively with duration of admission. Conclusion:. : We determined serum copper, zinc and lead in children with bronchial asthma. We found elevated serum copper and zinc in asthmatic children compared to controls with no relation to clinical manifestations or laboratory parameters .Serum lead showed no difference among patients and controls, however it increased in severe cases compared moderate and mild cases and correlated positively with duration of admission. These results indicate importance of environmental exposure as a risk factor of asthma in children
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