Haemoglobin concentrations in pregnancy and respiratory and allergic outcomes in childhood: Birth cohort study

Shaheen, Seif O.; Macdonald‐Wallis, Corrie; Lawlor, Debbie A.; Henderson, John

doi:10.1111/cea.13034

Cited by 21 publications

(19 citation statements)

References 36 publications

(73 reference statements)

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“…These results are in keeping with recent findings in ALSPAC in which we have found that lower maternal haemoglobin concentrations and anaemia in later pregnancy were associated with lower childhood lung function. 12 They are also consistent with limited evidence from the SEATON study, suggesting that low prenatal iron status was associated with lower FEV 1 , although in that study the association was with ferritin in early pregnancy. 10 In our study, statistical power was greater for analysis of lung function, a continuous outcome, than for analyses of binary outcomes.…”

Section: Discussionsupporting

confidence: 81%

“… 10 Iron deficiency is the most common cause of anaemia in pregnancy, 11 and recent analyses conducted in the ALSPAC birth cohort showed associations between lower maternal haemoglobin concentrations in pregnancy, and an increased risk of atopy, elevated IgE and reduced lung function in the offspring at 7 years of age. 12 In the USA, a prospective study found positive associations for maternal anaemia with both early childhood wheezing and persistent wheezing, 13 and a cross-sectional study in children reported positive associations between anaemia and atopic disease. 14 On the other hand, a prospective study conducted in the Netherlands did not confirm any association between maternal haemoglobin concentrations during pregnancy and wheezing in early childhood or asthma outcomes at the age of 6 years.…”

Section: Introductionmentioning

confidence: 99%

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Maternal iron status during pregnancy and respiratory and atopic outcomes in the offspring: a Mendelian randomisation study

et al. 2018

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IntroductionLimited evidence from birth cohort studies suggests that lower prenatal iron status may be a risk factor for childhood respiratory and atopic outcomes, but these observational findings may be confounded. Mendelian randomisation (MR) can potentially provide unconfounded estimates of causal effects by using common genetic variants as instrumental variables. We aimed to study the relationship between prenatal iron status and respiratory and atopic outcomes in the offspring using MR.MethodsIn the Avon Longitudinal Study of Parents and Children birth cohort, we constructed four maternal genotypic risk scores by summing the total number of risk alleles (associated with lower iron status) across single nucleotide polymorphisms known to be associated with at least one of four iron biomarkers (serum iron, ferritin, transferrin and transferrin saturation). We used MR to study their associations with respiratory and atopic outcomes in children aged 7–9 years (n=6002).ResultsWhen analyses were restricted to mothers without iron supplementation during late pregnancy, negative associations were found between the maternal transferrin saturation score and childhood forced expiratory volume in 1 s and forced vital capacity (difference in age, height and gender-adjusted SD units per SD increase in genotypic score: −0.05 (−0.09, −0.01) p=0.03, and −0.04 (−0.08, 0.00) p=0.04, respectively).ConclusionUsing MR we have found weak evidence suggesting that low maternal iron status during pregnancy may cause impaired childhood lung function.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Maternal iron status during pregnancy and respiratory and atopic outcomes in the offspring: a Mendelian randomisation study

et al. 2018

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“…92 We also identified iron as an underappreciated contributor to immune tolerance. Indeed, iron deficiency favors a T H 2 response [93][94][95] and allergy, [96][97][98] whereas too much iron leads to immunosuppression, 99 partly by increasing the ratio of Treg cells in relation to effector T cells. 100,101 An increase in intracellular iron has been linked to impaired antigen presentation and is associated with a suppressive phenotype in macrophages in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

Cow’s milk protein β-lactoglobulin confers resilience against allergy by targeting complexed iron into immune cells

Roth‐Walter

Afify

Pacios

et al. 2021

Journal of Allergy and Clinical Immunology

114

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“…In addition, some studies have suggested a correlation between the maternal iron levels during pregnancy and her baby's atopic disease including asthma or lung function [42][43][44]. Meanwhile, a recent study had shown that hemoglobin levels during the mother's pregnancy were associated with respiratory and allergic diseases in childhood [45]. Another study suggested the increased risk of IDA in infants with cow's milk allergy [46].…”

Section: Discussionmentioning

confidence: 99%

Atopic Disease and Anemia in Korean Patients: Cross-Sectional Study with Propensity Score Analysis

Rhew

Brown

2020

IJERPH

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Atopic disease is associated with chronic inflammation, and anemia has been reported in patients with inflammatory disorders such as rheumatoid arthritis, chronic obstructive pulmonary disease, and irritable bowel disease. The objective of this study was to determine whether atopic disease is associated with an increased risk of anemia. A cross-sectional study with propensity score weighting was conducted using a health insurance review agency claims dataset comprised of randomized patients who used the Korean national health system at least once in 2016. The association between atopic disease (asthma, atopic dermatitis, allergic rhinitis) and anemia (iron deficiency anemia (IDA) and/or anemia of inflammation (AI)) was examined. A total of 1,468,033 patients were included in this study. The IDA/AI prevalence was 3.1% (45,681 patients). After propensity score weighting, there were 46,958 and 45,681 patients in the non-anemic and anemic groups, respectively. The prevalence of IDA/AI in patients with atopic dermatitis, allergic rhinitis, or asthma had an odds ratio (OR) of 1.40 (95% confidence interval (CI), 1.33–1.48; p < 0.001), 1.17 (95% CI, 1.14–1.21; p < 0.001), and 1.32 (95% CI, 1.28–1.36; p < 0.001), respectively. In addition, the prevalence of IDA increased with higher numbers of atopic diseases. In conclusion, the prevalence of IDA/AI was higher in patients with atopic disease, even after adjusting for demographic characteristics and other risk factors. Further study is needed to distinguish between IDA and AI and to enhance understanding of the etiology of anemia in patients with inflammatory conditions.

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Haemoglobin concentrations in pregnancy and respiratory and allergic outcomes in childhood: Birth cohort study

Cited by 21 publications

References 36 publications

Maternal iron status during pregnancy and respiratory and atopic outcomes in the offspring: a Mendelian randomisation study

Maternal iron status during pregnancy and respiratory and atopic outcomes in the offspring: a Mendelian randomisation study

Cow’s milk protein β-lactoglobulin confers resilience against allergy by targeting complexed iron into immune cells

Atopic Disease and Anemia in Korean Patients: Cross-Sectional Study with Propensity Score Analysis

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