Irisolidone attenuates ethanol‐induced gastric injury in mice by inhibiting the infiltration of neutrophils

Kang, Geum-Dan; Lee, Sang Yoon; Jang, Se-Eun; Han, Myung Joo; Kim, Dong-Hyun

doi:10.1002/mnfr.201600517

Cited by 12 publications

(2 citation statements)

References 31 publications

(47 reference statements)

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“…11 In the stomach, cPLA2 activation subsequent to CYP2E1 activation, lipid peroxidation, and intracellular Ca 2+ release has been regarded as a direct mechanism of alcohol in the stomach and liver. 12 Under this condition, Kang et al 13 reported that irisolidone and kakkalide can attenuate ethanol-induced gastric injury by inhibiting the infiltration of neutrophils accompanied by either inhibiting IL-8 secretion or inactivating NF-κB. 15-PGDH has tumor suppressive activity against gastric and colon cancer but has never been studied in alcoholic gastritis, despite being inferred to have some cytoprotective actions.…”

Section: Discussionmentioning

confidence: 99%

Combined Extracts of Artemisia and Green Tea, Mitigated Alcoholic Gastritis Via Enhanced Heat-shock Protein 27

Kim

Jeong

Han

et al. 2018

Korean J Gastroenterol

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Background/Aims: Several lines of evidence from epidemiologic and laboratory studies have shown that the consumption of Artemisia or green tea extracts (MPGT) is inversely associated with the risk of alcohol-induced damage and other chronic diseases. Supported by previous studies showing that the combined extract of Artemisia and green tea, MPGT, exerted significantly either antioxidative or anti-inflammatory actions against Helicobacter pylori-associated gastric diseases, it was hypothesized that MPGT can offer protection against alcoholic gastritis. Methods: Ethanol was administered to induce gastric damage in Wistar rats, which had been pretreated with various doses of MPGT, to measure the rescuing action of a MPGT pretreatment against ethanol-induced gastric damage. In addition, the molecular mechanisms for the preventive effects were examined. Results: The MPGT pretreatment (100, 300, and 500 mg/kg) alleviated the ethanol-induced gastric damage, which was evidenced by the significant decrease in calcium-dependent phospholipase A2, MAPKs, and NF-B levels compared to ethanol alone. Furthermore, the MPGT pretreatment preserved 15-prostaglandin dehydrogenase, whereas cyclooxygenase-2 was decreased significantly. All of these biochemical changes led to the significant alleviation of alcohol-associated gastric mucosal damage. Ethanol significantly increased the TUNEL positivity in the stomach, but MPGT decreased the apoptotic index significantly, which was associated with significantly lower pathological scores of ethanol-induced mucosal ulcerations. The significant protective changes observed alcoholic gastritis with MPGT were related to the increased expression of cytoprotective genes, such as heat-shock protein (HSP)27, HSP60, and PDGF. Conclusions: The efficient anti-inflammatory, anti-apoptotic, and regenerative actions of MPGT make it a potential nutrient phytoceutical to rescue the stomach from alcoholic gastritis. (Korean J Gastroenterol 2018;71:132-142)

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Section: Discussionmentioning

confidence: 99%

Combined Extracts of Artemisia and Green Tea, Mitigated Alcoholic Gastritis Via Enhanced Heat-shock Protein 27

Kim

Jeong

Han

et al. 2018

Korean J Gastroenterol

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“…CXCL4 is a multifunctional chemokine that regulates immune response and participates in angiogenesis [20][21][22]. CXCL4 has been reported to be increased in a variety of in ammatory diseases [23,24]. Therefore, Multiple experiments were conducted to study the relationship between pyroptosis and CXCL4 in VMC mice.…”

Section: The Pyroptosis Of Mcf Promotes the Secretion Of Cxcl4mentioning

confidence: 99%

Cardiac fibroblasts pyroptosis mediated by NLRP3/Caspase-1/GSDMD-N pyroptotic pathway produces CXCL4 via Wnt/β-Catenin signaling and induces cardiac fibrosis

Wei,

Peng,

Wang

et al. 2023

Preprint

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Severe myocarditis is often accompanied by cardiac fibrosis, but the underlying mechanism has not been fully elucidated. NOD-like receptor protein 3 (NLRP3) inflammation, closely related to apoptosis pyroptosis, participates in the development of myocarditis. Inhibiting pyroptosis mediated by NLRP3 inflammasome can reduce cardiac fibrosis, although its exact mechanism remains unknown. In this study, we induced Viral myocarditis (VMC) via infection of CVB3 to explore the relationship between pyroptosis and fibrosis. Our results showed that intraperitoneal injection of an NLRP3 inhibitor MCC950 or use of NLRP3−/−mice inhibited cardiac pyroptosis mediated by NLRP3 inflammasome in VMC. CXCL4 is a chemokine that has been reported to have pro-inflammatory and pro-fibrotic functions. In VMC, we further found that pyroptosis of Mouse myocardial fibroblasts (MCF) promoted the secretion of CXCL4 by activating Wnt/β-Catenin signaling. Subsequently, the transcriptome sequencing data showed that CXCL4 could promote cardiac fibrosis by activating PI3K/AKT pathway. In summary, infection of CVB3 induced host oxidative stress to further activate the NLRP3 inflammasome and ultimately lead to heart pyroptosis, in which MCF secreted CXCL4 by activating Wnt/β-Catenin signaling and CXCL4 participated in cardiac fibrosis by activating PI3K/AKT pathway. Therefore, our findings revealed the role of CXCL4 in VMC and unveiled its underlying mechanism. CXCL4 appears to be a potential target for the treatment of VMC.

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Methylsulfonylmethane is effective against gastric mucosal injury

Amirshahrokhi

Khalili

2017

European Journal of Pharmacology

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Irisolidone attenuates ethanol‐induced gastric injury in mice by inhibiting the infiltration of neutrophils

Abstract: Irisolidone may attenuate ethanol-induced gastritis by inhibiting the infiltration of immune cells, particularly neutrophils, through the regulation of CXCL-4 or IL-8 secretion.

Cited by 12 publications

References 31 publications

Combined Extracts of Artemisia and Green Tea, Mitigated Alcoholic Gastritis Via Enhanced Heat-shock Protein 27

Combined Extracts of Artemisia and Green Tea, Mitigated Alcoholic Gastritis Via Enhanced Heat-shock Protein 27

Cardiac fibroblasts pyroptosis mediated by NLRP3/Caspase-1/GSDMD-N pyroptotic pathway produces CXCL4 via Wnt/β-Catenin signaling and induces cardiac fibrosis

Methylsulfonylmethane is effective against gastric mucosal injury

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