Methylsulfonylmethane is effective against gastric mucosal injury

Amirshahrokhi, Keyvan; Khalili, Ali-Reza

doi:10.1016/j.ejphar.2017.06.034

Cited by 32 publications

(13 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the process of alcohol-induced gastric ulcers, the submucosa of the tissue can usually be infiltrated by inflammatory cells. Inflammatory cells are the main source of MMPs (36) and MCP-1 is closely related to inflammation (21). We found that the levels of MMP-9 and MCP-1 did not increase, and no corresponding inflammatory cells were found in the pathological sections.…”

Section: Discussionmentioning

confidence: 63%

Lycopene Aggravates Acute Gastric Injury Induced by Ethanol

et al. 2021

View full text Add to dashboard Cite

Lycopene is an important natural red pigment with strong singlet oxygen and peroxide free radical quenching ability. Ethanol directly destroys the epithelial cells of gastric mucosa, causing oxidative damage and inflammation. To evaluate the effect of lycopene on the ethanol induced gastric injury, 112 adult male Kunming mice were randomly divided into normal control, lycopene control, gastric injury control, omeprazole (20 mg/kg) positive control, and lycopene experimental groups (at doses of 10, 50, 100, and 150 mg/kg body weight) in this study. The general and pathological evaluation, gastric secretion, as well as the levels of antioxidant and inflammatory factors were detected. In lycopene experimental groups, the amount of gastric juice were lower than that in the gastric injury control group; the levels of T-SOD, and the levels of MDA and inflammatory factors (MMP-9 and MCP-1) decreased. However, general and pathological evaluation of gastric tissues revealed that lycopene (especially at high doses) could aggravate acute gastric mucosal injury induced by ethanol. Therefore, lycopene (especially at high doses) aggravates acute gastric mucosal injury caused by ethanol, but this was not due to oxidative stress or inflammatory factors. In lycopene control group, the levels of MTL, T-SOD, and NO increased, but the levels of ALT and AST decreased, indicating that lycopene has a protective effect on the stomach and liver when ethanol wasn't taken. It reminds us that, when alcohol is consumed in large quantities, consumption of lycopene products should be carefully considered.

show abstract

Section: Discussionmentioning

confidence: 63%

Lycopene Aggravates Acute Gastric Injury Induced by Ethanol

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In contrast, reversal of Cyp2c29 expression in APAP-and CCl 4 -induced hepatotoxicity (two common models of liver injury), resulted in suppression of pro-inflammatory signaling and cytokine production by targeting NF-kB pathway [42]. Interestingly, similar anti-inflammatory effects associated with NF-kB inhibition were reported for MSM [43,44]. These findings may have a significant therapeutic value and further investigations of the MSM/CRCE interaction potential and its effects on NF-kB signaling pathway are clearly warranted.…”

Section: Discussionmentioning

confidence: 87%

Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration

Kutanzi

Ewing

Skinner

et al. 2020

IJMS

View full text Add to dashboard Cite

Cannabidiol (CBD) is a biologically active, non-psychotropic component of Cannabis sativa whose popularity has grown exponentially in recent years. Besides a wealth of potential health benefits, ingestion of CBD poses risks for a number of side effects, of which hepatotoxicity and CBD/herb-drug interactions are of particular concern. Here, we investigated the interaction potential between the cannabidiol-rich cannabis extract (CRCE) and methylsulfonylmethane (MSM), a popular dietary supplement, in the mouse model. For this purpose, 8-week-old male C57BL6/J mice received MSM-containing water (80 mg/100 mL) ad libitum for 17 days. During the last three days of treatment, mice received three doses of CRCE administered in sesame oil via oral gavage (123 mg/kg/day). Administration of MSM alone did not result in any evidence of liver toxicity and did not induce expression of mouse cytochrome P450 (CYP) enzymes. Administration of CRCE did produce significant (p < 0.05) increases in Cyp1a2, Cyp2b10, Cyp2c29, Cyp3a4, Cyp3a11, Cyp2c65, and Cyp2c66 messenger RNA, however, this effect was not amplified by MSM/CRCE co-treatment. Similarly, no evidence of liver toxicity was observed in MSM/CRCE dosed mice. In conclusion, short-term MSM/CRCE co-administration did not demonstrate any evidence of hepatotoxicity in the mouse model.

show abstract

“…Effect of Lycopene administration on colon tissue L-MDA, CAT and GSH of acetic acid-induced ulcerative colitis in male rats was presented in table (1).The obtained results showed significant increase L-MDA concentration with marked decreases in CAT activity and GSH concentrations in colon of acetic acid -induced ulcerative colitis in rats as compared with control normal group. However, a significant depletion of colon tissue L-MDA concentration and marked increase in CAT activity and GSH concentrations were observed after LYC treatment compared to ulcerated untreated rats.…”

Section: Resultsmentioning

confidence: 94%

“…These lead to production of superoxide anion and initiation of a cascade for the production of various reactive species. Malondialdehyde (MDA) is one of the end products of the lipid peroxidation procedure and increasing in the free radical activity causes overproduction of MDA (Amirshahrokhi and Khalili, 2017). Endogenous antioxidant defenses against reactive oxygen species (ROS) production even in low concentrations influence on two main types: (1) enzymatic (CAT) and (2) non-enzymatic (GSH) (Halliwell and Gutteridge, 2007).…”

Section: Introductionmentioning

confidence: 99%

Lycopene mitigates experimental colitis in rats by inhibiting oxidative stress-mediated inflammation and apoptosis

Hashem

Hussein

Senosi

2020

Benha Veterinary Medical Journal

View full text Add to dashboard Cite

The potential protective and beneficial effects of Lycopene (LYC) in a rat model of acetic acid-induced ulcerative colitis (UC) were evaluated. Forty male albino rats were divided into five equal groups. Group I: (Control normal) rats received no drugs. Group II: (Early ulcerative colitis): rats received 2 ml (3% v/v) glacial acetic acid intra-colonially at 21 th day of experiment and sacrificed 3 days later. Group III:(Early ulcerative colitis + Lycopene protected) rats received Lycopene (10 mg/kg body weight/day, orally) for 21 successive days prior to acetic acid administration. Group IV: (Late ulcerative colitis) rats received acetic acid similar to group II for 3 successive days and sacrificed after 21 days. Group V: (Late ulcerative colitis+ Lycopene treated) rats first administered with acetic acid then after 3 days Lycopene was administered for 21successive days. A significant increase in L-Malondialdehyde (L-MDA) with marked decreases in reduced glutathione (GSH) level and Catalase (CAT) activity were observed in colon tissue of UC-induced rats. Additionally, a significant up-regulation of nuclear factor kappa B (NF-κB), caspase-3 and transforming growth factor-β1 (TGF-β1) and down-regulation of Interleukin-10 (IL-10) and Beta cell lymphoma-2 (Bcl-2) gene expression levels were observed in colon of UC induced rats. However, a significant depletion of colon tissue L-MDA and down-regulation of NF-κB, caspase-3 and TGF-β1 in addition to marked increases in GSH concentration and CAT activity and up-regulation of IL-10 and Bcl-2 were observed after LYC treatment. Lycopene has powerful antioxidants, anti-inflammatory and anti-apoptotic effects against ulcerative colitis.

show abstract

Methylsulfonylmethane is effective against gastric mucosal injury

Cited by 32 publications

References 34 publications

Lycopene Aggravates Acute Gastric Injury Induced by Ethanol

Lycopene Aggravates Acute Gastric Injury Induced by Ethanol

Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration

Lycopene mitigates experimental colitis in rats by inhibiting oxidative stress-mediated inflammation and apoptosis

Contact Info

Product

Resources

About