Cardiac fibroblasts pyroptosis mediated by NLRP3/Caspase-1/GSDMD-N pyroptotic pathway produces CXCL4 via Wnt/β-Catenin signaling and induces cardiac fibrosis
Jing Wei,
Ming yu Peng,
Sai nan Wang
et al.
Abstract:Severe myocarditis is often accompanied by cardiac fibrosis, but the underlying mechanism has not been fully elucidated. NOD-like receptor protein 3 (NLRP3) inflammation, closely related to apoptosis pyroptosis, participates in the development of myocarditis. Inhibiting pyroptosis mediated by NLRP3 inflammasome can reduce cardiac fibrosis, although its exact mechanism remains unknown. In this study, we induced Viral myocarditis (VMC) via infection of CVB3 to explore the relationship between pyroptosis and fibr… Show more
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