Iris Thickness and Severity of Neovascular Glaucoma Determined Using Swept-Source Anterior-segment Optical Coherence Tomography

Nakakura, Shunsuke; Kobayashi, Yui; Matsuya, Kanae; Terao, Etsuko; Kiuchi, Yoshiaki

doi:10.1097/ijg.0000000000000921

Cited by 7 publications

(8 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Second, our method for the measurement of IT[5,6,7] (i.e., measured from the edge of the pupil) and that used also by Invernizzi A et al,[10] (i.e., measured at the thickest point) were different from those employed in other previous studies[4,8,11] (i.e., measured near the angle). However, the root of the iris exhibits variations.…”

Section: Discussionmentioning

confidence: 99%

“…In our analysis, the IT was measured from the edge of the pupil in line with the hyperreflective line at the bottom of the iris. The IT was measured twice at 1 and 2 mm (± 0.005 mm) from the edge of the pupil (Fig 1A) used in our previous study,[6,7] and the mean of two measurements was used for subsequent analysis. The eyes of children with large mydriasis in the dark room condition were not suitable for measuring IT because the distal point (2 mm) from the edge of the pupil will locate the angle or cornea.…”

Section: Methodsmentioning

confidence: 99%

“…Especially, iris thickness (IT) (i.e., CT) is a simple morphological parameter to determine the pathology of the iris. A previous study showed that the IT decreased in patients with Fuch’s uveitis,[4] pseudoexfoliation syndrome,[5] neovascular glaucoma,[6,7] and primary congenital glaucoma. [8] In contrast, it increased in patients with sympathetic ophthalmia.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Determination of iris thickness development in children using swept-source anterior-segment optical coherence tomography

Nakakura¹,

Nagata²,

Shimizu³

et al. 2019

PLoS ONE

Self Cite

View full text Add to dashboard Cite

Purpose The uvea comprises the iris, ciliary body, and choroid. However, the development of the anterior part (iris and ciliary body) in children is not yet fully elucidated. We investigated the iris thickness (IT) in children using swept-source anterior-segment optical coherence tomography (ASOCT). Methods In this retrospective, clinic-based study, we enrolled 41 children (mean ± standard deviation: 6.8 ± 3.3 years; range: 3–16; 17 males) with normal or mild refractive error. Horizontal scanning images of swept-source ASOCT were analyzed in temporal and nasal angle areas. The ITs at 1 and 2 mm from the pupil edge were measured using swept-source ASOCT. The association between IT and age, sex, and ocular morphological parameters (i.e., axial length, average corneal curvature, central corneal thickness, inter-scleral spur distance, and anterior chamber depth) was assessed using Pearson’s correlation coefficient (r) and linear regression analysis. Results The average IT (temporal and nasal) at 1 and 2 mm were 0.432 ± 0.060 (0.302−0.569 mm) and 0.337 ± 0.045 (0.229−0.414 mm), respectively. There was a significant correlation between age and average IT ( r = 0.45, P = 0.002 at 1 mm and r = 0.31, P = 0.042 at 2 mm). Multiple linear regression analysis revealed that age (coefficient: 0.01), axial length (−0.02), average corneal curvature (0.01), and anterior chamber depth (0.01) at 1 mm as well as age (0.00), average corneal curvature (0.09), anterior chamber depth (0.06), and male (–0.02) at 2 mm were identified as predictors of IT. Conclusions IT in children increases with age. Additionally, IT was thinner with longer axial length and in males, thicker in eyes with deeper anterior chamber and flatter corneal curvature. Our study may partly explain the development of eyeball structures in children.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Determination of iris thickness development in children using swept-source anterior-segment optical coherence tomography

Nakakura¹,

Nagata²,

Shimizu³

et al. 2019

PLoS ONE

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, the anterior opening distance at 500 μm was 0.377/0.387 mm (temporal and nasal) and 0.137/0.218 mm, respectively. Iris thickness, measured from the edge of the pupil [9], was as follows: right eye, 0.460/0.358 mm (temporal and nasal) at 1 mm and 0.410/0.287 mm at 2 mm; left eye, 0.523/0.516 mm at 1 mm and 0.337/0.414 mm at 2 mm ( Fig. 1, third panel).…”

Section: Case Reportmentioning

confidence: 99%

CHARGE Syndrome Associated with Angle Closure despite High Myopia: A Case Report with Structural Suggestion

Dote¹,

Nakakura²,

Tanabe³

et al. 2020

Case Rep Ophthalmol

Self Cite

View full text Add to dashboard Cite

CHARGE syndrome is associated with multiple malformations, and the main ocular abnormality is coloboma. We describe an unusual case of a 15-year-old girl with CHARGE syndrome having high intraocular pressure and narrow angle closure despite refractive high myopia (−9.0 dpt) in her left eye. Gonioscopy revealed peripheral anterior synechia (approximately 90°) in the superior quadrant of the left eye. Both eyes exhibited similar axial length (about 22 mm) and corneal curvature (about 8 mm). However, microcornea (9 mm), thicker central cornea and iris induced narrower anterior components in the left eye than in the right eye. Preventing the chance of acute primary angle closure attack, the patient underwent laser iridotomy in the left eye; however, long-term follow-up is needed. Additionally, we developed a hypothesis for the mechanism of unilateral angle closure despite high myopia by investigating the ocular structural parameters in detail.

show abstract

“…Furthermore, can be used to evaluate the iris and angle configuration before and after laser iridotomy. With high-resolution SS-OCT imaging, it is also possible to detect changes of the iris in neovascular glaucoma [39]. SS-OCT imaging offers other potential anterior chamber applications such as flare measurement in the anterior chamber, which has been shown comparable to laser flare meter measurements [40].…”

Section: Ss-oct and Anterior Chamber Evaluationmentioning

confidence: 99%

Anterior Segment OCT

Asam

Polzer

Tafreshi

et al. 2019

High Resolution Imaging in Microscopy and Ophthalmology

View full text Add to dashboard Cite

Iris Thickness and Severity of Neovascular Glaucoma Determined Using Swept-Source Anterior-segment Optical Coherence Tomography

Abstract: IT decreases with the progression of the NVG stage and is thinnest in 360-degree AC-NVG patients. Our study suggests a new morphologic feature of NVG.

Cited by 7 publications

References 23 publications

Determination of iris thickness development in children using swept-source anterior-segment optical coherence tomography

Determination of iris thickness development in children using swept-source anterior-segment optical coherence tomography

CHARGE Syndrome Associated with Angle Closure despite High Myopia: A Case Report with Structural Suggestion

Anterior Segment OCT

Contact Info

Product

Resources

About