Determination of iris thickness development in children using swept-source anterior-segment optical coherence tomography

Nakakura, Shunsuke; Nagata, Yuki; Shimizu, Yukiko; Kawai, Akiko; Tabuchi, Hitoshi; Kiuchi, Yoshiaki

doi:10.1371/journal.pone.0217656

Cited by 13 publications

(5 citation statements)

References 24 publications

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“…Additionally, we have previously reported that temporal mean iris thickness values in children (3-16 years) at 1 and 2 mm were 0.405 and 0.336 mm, respectively. In the nasal angle area, the mean iris thickness values were 0.459 and 0.338 mm, respectively [11], which also supports the thicker iris in the left eye. Therefore, the anterior chamber of the left eye became more cramped compared to the right eye.…”

Section: Discussionsupporting

confidence: 62%

CHARGE Syndrome Associated with Angle Closure despite High Myopia: A Case Report with Structural Suggestion

Dote¹,

Nakakura²,

Tanabe³

et al. 2020

Case Rep Ophthalmol

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CHARGE syndrome is associated with multiple malformations, and the main ocular abnormality is coloboma. We describe an unusual case of a 15-year-old girl with CHARGE syndrome having high intraocular pressure and narrow angle closure despite refractive high myopia (−9.0 dpt) in her left eye. Gonioscopy revealed peripheral anterior synechia (approximately 90°) in the superior quadrant of the left eye. Both eyes exhibited similar axial length (about 22 mm) and corneal curvature (about 8 mm). However, microcornea (9 mm), thicker central cornea and iris induced narrower anterior components in the left eye than in the right eye. Preventing the chance of acute primary angle closure attack, the patient underwent laser iridotomy in the left eye; however, long-term follow-up is needed. Additionally, we developed a hypothesis for the mechanism of unilateral angle closure despite high myopia by investigating the ocular structural parameters in detail.

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Section: Discussionsupporting

confidence: 62%

CHARGE Syndrome Associated with Angle Closure despite High Myopia: A Case Report with Structural Suggestion

Dote¹,

Nakakura²,

Tanabe³

et al. 2020

Case Rep Ophthalmol

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“…The scleral spur anatomically represents the junction between the inner wall of the trabecular meshwork and the sclera and is marked by a prominent inner extension (inward protrusion) of the sclera with a change in curvature of its inner surface [ 13 ]. This was identified in this study based on Nakakura et al [ 14 ].…”

Section: Methodsmentioning

confidence: 78%

The Iris Thickness in a Healthy Saudi Population

Ziaul¹,

Mahale²,

Varghese³

et al. 2021

Cureus

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Purpose Iris thickness (IT), a known risk factor for angle closure glaucoma, has not been evaluated in the normal Saudi population. Methods Quantitative information on IT was evaluated in healthy Saudi eyes using anterior segment optical coherence tomography (ASOCT). IT and iris volume was measured with the room ‘light on’ (LON) and ‘light off’ (LOFF) using Image J software. IT in the nasal and temporal iris was measured at 500 µm (IT500) and 750 µm (IT750) from the scleral spur (SS). Differences in IT measurements by age, gender and type of refractive error were evaluated. Results We included 100 eyes of 50 healthy adult Saudis without ocular disease other than refractive errors. The mean age of 56 males and 44 females in the study group was 41.7 ± 14.5 years. The refractive status was as follows: emmetropia (35 eyes), mild/moderate myopia (33 eyes), high myopia (17 eyes) and hyperopia (15 eyes). The IT750 with LON was significantly more than IT500 both nasally (P = 0.03) and temporally (P < 0.001). The difference in IT750 and IT500 with LOFF was significantly more nasally (P = 0.03), temporally (P = 0.02), and with LON nasally (P = 0.005). IT was thicker in males when compared to females and variation of IT by refractive error was significant but not by age. The mean pupil diameter and anterior chamber depth decreased with age (P < 0.001). Anterior chamber width was not affected by age or illumination. Conclusion The baseline iris thickness in the Saudi eyes could be used to compare iris thickness in eyes with angle closure glaucoma among the Arab population.

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“…Children have a low IT because their iris has not yet developed completely. 25,26 Older adults may have a lowest IT due to age-related degeneration of the iris. The three layers of the iris were affected to different degrees, and histological studies should be conducted to investigate this.…”

Section: Resultsmentioning

confidence: 99%

Decreased iris thickness on swept‐source optical coherence tomography in patients with primary open‐angle glaucoma

Chen

Liang

Chen

et al. 2021

Clinical Exper Ophthalmology

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To investigate the iris thickness (IT) of patients with primary open-angle glaucoma (POAG) and older adults using anterior segment sweptsource optical coherence tomography (SS-OCT).Methods: In this comparative cross-sectional study, 154 participants were enrolled, including 40 patients with POAG and 114 healthy individuals. Nasalangle SS-OCT images were analysed using callipers to measure the thickness of the iris, including the anterior border layer, stromal, and pigmented epithelial layer, at 1 and 2 mm from the pupil edge. The relationship between IT and glaucoma severity was analysed, and receiver operating characteristic curves were constructed to assess the ability of each IT parameter to distinguish patients with glaucoma from healthy controls. Results:The IT parameters and iris area were lower in the POAG group than in the age-matched control group (p < 0.05). In the POAG group, the thickness of the pigmented epithelial layer at 1 and 2 mm was significantly correlated with the severity of glaucoma (p < 0.05). Iris area, with a cut-off of 1.43 mm 2 , exhibited the highest sensitivity (85%) and specificity (64.81%; area under the curve = 0.783) for distinguishing patients with POAG from healthy controls. Older adults tended to have the thinnest IT, children had the smallest iris area (p < 0.05). Conclusions:In patients with POAG, the severity of iris atrophy was associated with glaucoma severity. The results of IT measurements by SS-OCT may help in the clinical evaluation of POAG.Glaucoma is the leading cause of irreversible blindness, primary open-angle glaucoma (POAG) accounts for the majority of glaucoma cases worldwide. [1][2][3] It is characterised by progressive and painless loss of retinal ganglion cells and their axons, leading to gradual, but irreversible, visual field loss. Aging is an important risk factor for POAG. 4 Early detection of POAG is critical for vision preservation and reducing the financial burden of patients. 5,6 Aqueous outflow obstruction plays an important role in intraocular pressure elevation in patients with POAG.Zhiqi Chen and Xin Liang contributed equally to this work

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Determination of iris thickness development in children using swept-source anterior-segment optical coherence tomography

Cited by 13 publications

References 24 publications

CHARGE Syndrome Associated with Angle Closure despite High Myopia: A Case Report with Structural Suggestion

CHARGE Syndrome Associated with Angle Closure despite High Myopia: A Case Report with Structural Suggestion

The Iris Thickness in a Healthy Saudi Population

Decreased iris thickness on swept‐source optical coherence tomography in patients with primary open‐angle glaucoma

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