Iridoids: Research Advances in Their Phytochemistry, Biological Activities, and Pharmacokinetics

Wang, Congcong; Gong, Xue; Bo, Agula; Zhang, Lei; Zhang, Mingxu; Zang, Erhuan; Zhang, Chunhong; Li, Min-Hui

doi:10.3390/molecules25020287

Cited by 116 publications

(72 citation statements)

References 98 publications

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“…Iridoids are a kind of very important natural products in plant kingdom, structurally characterized with bicyclic cis-fused cyclopentane-pyrans or cleavage of a bond in the cyclopentane ring (secoiridoid). Clinically, iridoids extract or traditional Chinese medicine rich in iridoids have been proved with anti-inflammatory, antiviral and antitumor effects, as well as protection of cardiovascular and immunomodulatory activities ( Wang et al, 2020 ; Jie et al, 2015 ; Ji et al, 2019 ; Luan et al, 2019 ). To date, 21 iridoids (123–143) have been isolated in Herba Patriniae.…”

Section: Phytochemistrymentioning

confidence: 99%

The Herba Patriniae (Caprifoliaceae): A review on traditional uses, phytochemistry, pharmacology and quality control

Gong

Zou

Zheng

et al. 2021

Journal of Ethnopharmacology

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Ethnopharmacological relevance Herba Patriniae has been used for thousands of years in China as a traditional Chinese medicine with heat-clearing and detoxicating effects. It is applied widly for the treatment of rheumatoid arthritis, diarrhea, acute hepatitis, pelvic inflammatory disease and ulcerative colitis in clinic. Two species, namely Patrinia scabiosaefolia Fisch. ( PS ) and Patrinia villosa Juss. ( PV ) from the Caprifoliaceae family, are considered as Herba Patriniae in the pharmaceutical industry. Aim of the review This paper aims to comprehensively outline the traditional uses, botanical description, phytochemistry, pharmacology, toxicology, quality control, pharmacokinetics and patents of Herba Patriniae, and elaborate the same/different characteristics between PS and PV . Materials and methods Detailed information of Herba Patriniae was collected from various online databases (Pubmed, Web of Science, Google Schola, China National Knowledge Infrastructure Database, National Intellectual Property Administration, PRC National Medical Products Administration), and those published resources (M.Sc. Thesis and books). Results A total of 233 compounds have been identified in Herba Patriniae, including triterpenoid saponins, flavonoids, organic acids, iridoids, and volatiles. A very distinct difference was observed, that PS is rich in triterpenoid saponins and volatiles, while PV contains more flavonoids. Two source species of Herba Patriniae gave similar pharmacological effects on anti-cancer, anti-inflammatory, antioxidant, antimicrobial, sedative and hypnotic effects. But there were no reports were on antipruritic, proangiogenic and anti-diarrheal effects for PS , and no studies on anti-diabetic effects for PV . Generally, Herba Patriniae showed non-toxic in the clinical dose, but mild side effects, such as temporary leukopenia, dizziness and nausea, could be found when large and excessive dosage is used. A variety of compounds have been quantified for the quality control of PS and PV . The variety, growth environment, growth time, and harvest time not only affected the contents but also the pharmacological activities of the bioactive compounds. In the past year, patents for compositions containing PV and PS have been filed, mainly involving human health, hygiene, agriculture, and animal husbandry. Unfortunately, the research on pharmacokinetics is insufficient. Only the prototype components and metabolites were repored after intragastric administration of total flavonoids extract from PV in rats. ...

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Section: Phytochemistrymentioning

confidence: 99%

The Herba Patriniae (Caprifoliaceae): A review on traditional uses, phytochemistry, pharmacology and quality control

Gong

Zou

Zheng

et al. 2021

Journal of Ethnopharmacology

View full text Add to dashboard Cite

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“…In conclusion, iridoids are interesting bioactive compounds largely used in skin disorders mostly due to their anti-inflammatory and antioxidant properties [41,42].…”

Section: Iridoidsmentioning

confidence: 99%

Olive Fruit and Leaf Wastes as Bioactive Ingredients for Cosmetics—A Preliminary Study

et al. 2021

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Olea europaea cultivar, native in the Mediterranean basin, has expanded worldwide, mainly due to the olive oil industry. This expansion is attributed to the benefits of olive oil consumption, since this product is rich in nutritional and bioactive compounds. However, the olive industry generates high amounts of wastes, which could be related to polluting effects on soil and water. To minimize the environmental impact, different strategies of revalorization have been proposed. In this sense, the aim of this work was to develop high cosmetic value added oleuropein-enriched extracts (O20 and O30), a bioactive compound from olive byproducts, performing a comprehensive characterization using high performance liquid chromatography coupled to mass spectrometry and evaluate their bioactivity by in vitro assays. A total of 49 compounds were detected, with oleuropein and its derivatives widely found in O30 extract, whereas iridoids were mainly detected in O20 extract. Moreover, 10 compounds were detected for the first time in olive leaves. Both extracts demonstrated strong antioxidant and antiradical activities, although O30 showed higher values. In addition, radical oxygen and nitrogen species scavenging and enzyme inhibition values were higher in O30, with the exception of HOCl and hyaluronidase inhibition assays. Regarding cell viability, olive byproduct extracts did not lead to a decrease in keratinocytes viability until 100 µg/mL. All data reported by the present study reflect the potential of industrial byproducts as cosmetic ingredients.

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“…jasminoides and Zhizhi ( 9 , 50 ). These compounds possess high antioxidant potential and elucidated neuroprotective, hepatoprotective, anti-inflammatory, antitumor, hypoglycemic, and hypolipidemic activities ( 51 , 52 ). Thus, both the fruits and flowers of Gardenia spp.…”

Section: Resultsmentioning

confidence: 99%

Recovery of Crocins From Floral Tissue of Gardenia jasminoides Ellis

et al. 2020

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In this research, a novel source of phytopigment crocins from fully open mature flowers of cape jasmine ( Gardenia jasminoides ) is introduced. Methanol and deionized water were appropriate solvents for pigment recovery with maximum yields of at least 17% from the floral tissue. Pigment separation by thin layer chromatography also confirmed the presence of the carotenoids, which dissolved well in these high-strength polar solvents, in fruit, flower, and leaf materials. The spectral patterns of the extracts from ultraviolet and nuclear magnetic resonance showed maximum absorption at ~420 nm and the chemical shift values were similar to those of crocetin aglycones (crocins) in the methanol extracts of a commercial source of yellow gardenia (fructus or fruit of Gardenia florida ). Chemical compositions were then evaluated using aqueous-phase capillary electrophoresis of the methanol extracts. The methanolic extracts of the flowers and fruit had 11 principal ingredients in common. Among these, crocetin and crocin 2 belong to the crocin group and are known to be the major components of commercial yellow Gardenia . This research not only demonstrates a sustainable means of raw material utilization for natural product recovery, but also encourages a movement toward an edible landscape for the community.

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Iridoids: Research Advances in Their Phytochemistry, Biological Activities, and Pharmacokinetics

Cited by 116 publications

References 98 publications

The Herba Patriniae (Caprifoliaceae): A review on traditional uses, phytochemistry, pharmacology and quality control

The Herba Patriniae (Caprifoliaceae): A review on traditional uses, phytochemistry, pharmacology and quality control

Olive Fruit and Leaf Wastes as Bioactive Ingredients for Cosmetics—A Preliminary Study

Recovery of Crocins From Floral Tissue of Gardenia jasminoides Ellis

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